ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADAM8
Symbol Alias	CD156, MS2
Approved Name	ADAM metallopeptidase domain 8
Previous Name	a disintegrin and metalloproteinase domain 8
Location	10q26.3
Position	chr10:135075907-135090407, -
External Links	HGNC: 215 Entrez Gene: 101 Ensembl: ENSG00000151651 UCSC: uc010quz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 16)

Literature-origin SNPs (count: 0)

LD-proxies (count: 16)

rs_ID	Location	Functional Annotation
rs11101672	Chr10:135081754(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2995300	Chr10:135076523(Fwd)	3_prime_UTR_variant; nc_transcript_variant; non_coding_exon_variant
rs3008324	Chr10:135086380(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs2230576	Chr10:135076596(Fwd)	3_prime_UTR_variant; nc_transcript_variant; non_coding_exon_variant
rs2275725	Chr10:135089035(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs2995307	Chr10:135079788(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2995318	Chr10:135091159(Fwd)	downstream_gene_variant; upstream_gene_variant
rs2995308	Chr10:135079862(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs3008328	Chr10:135092590(Fwd)	downstream_gene_variant; upstream_gene_variant
rs2995310	Chr10:135082810(Fwd)	downstream_gene_variant; intron_variant
rs3008321	Chr10:135084322(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs2995314	Chr10:135084601(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs7912335	Chr10:135071004(Fwd)	downstream_gene_variant
rs3008323	Chr10:135086203(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1131718	Chr10:135085754(Fwd)	downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant
rs2275724	Chr10:135088741(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_23	chr10:132453545-135284293 (NCBI36 / hg18)	2830749	10q26.3	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 43)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 43)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005887	integral to plasma membrane	Cellular Component	IDA[18397961]	220
GO:0006508	proteolysis	Biological Process		102
GO:0005737	cytoplasm	Cellular Component	IDA[18397961]	690
GO:0005886	plasma membrane	Cellular Component	IDA[17548643]	772
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005515	protein binding	Molecular Function	IPI[12777399]	910
GO:0002675	positive regulation of acute inflammatory response	Biological Process		4
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0022407	regulation of cell-cell adhesion	Biological Process	IDA[17548643]	2
GO:0032010	phagolysosome	Cellular Component	IDA[17548643]	2
GO:0010954	positive regulation of protein processing	Biological Process	NAS[17548643]	2
GO:0016337	cell-cell adhesion	Biological Process		13
GO:0008270	zinc ion binding	Molecular Function	TAS[18397961]	323
GO:0009986	cell surface	Cellular Component	IDA[17548643]	70
GO:0006954	inflammatory response	Biological Process	IDA[17548643]	51
GO:0008237	metallopeptidase activity	Molecular Function	IDA[12777399]	13
GO:0045785	positive regulation of cell adhesion	Biological Process		7
GO:0045780	positive regulation of bone resorption	Biological Process		6
GO:0043621	protein self-association	Molecular Function	TAS[12777399]	8
GO:0043524	negative regulation of neuron apoptotic process	Biological Process		19
GO:0042581	specific granule	Cellular Component	IDA[17548643]	5
GO:0035419	activation of MAPK activity involved in innate immune response	Biological Process		1
GO:0033089	positive regulation of T cell differentiation in thymus	Biological Process		4
GO:0032127	dense core granule membrane	Cellular Component	IDA[17548643]	1
GO:0070820	tertiary granule	Cellular Component	IDA[17548643]	2
GO:0070245	positive regulation of thymocyte apoptotic process	Biological Process		1
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process		17
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	Biological Process	IDA[15220135]	3
GO:0050839	cell adhesion molecule binding	Molecular Function	IPI[12777399]	9
GO:0050714	positive regulation of protein secretion	Biological Process	IC[17548643]	5
GO:0048247	lymphocyte chemotaxis	Biological Process		1
GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex	Cellular Component	IDA[15220135]	1
GO:0071133	alpha9-beta1 integrin-ADAM8 complex	Cellular Component		1
GO:0071456	cellular response to hypoxia	Biological Process	IDA[18566576]	12
GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	Biological Process		1
GO:2000391	positive regulation of neutrophil extravasation	Biological Process	IDA[17548643]	1
GO:2000415	positive regulation of fibronectin-dependent thymocyte migration	Biological Process		1
GO:2000418	positive regulation of eosinophil migration	Biological Process		1
GO:0001525	angiogenesis	Biological Process		35
GO:0000902	cell morphogenesis	Biological Process		7
GO:0002523	leukocyte migration involved in inflammatory response	Biological Process		3
GO:0002102	podosome	Cellular Component	IDA[15220135]	3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ADAM8 (count: 37)

Gene Symbol	Pathway Count	Pathway List
ADAM17	8	integral to plasma membrane; cytoplasm; plasma membrane; protein binding; metalloendopeptidase activity; zinc ion binding; cell surface; metallopeptidase activity;
MMP16	7	integral to plasma membrane; proteolysis; plasma membrane; calcium ion binding; metalloendopeptidase activity; zinc ion binding; cell surface;
PRKD1	7	integral to plasma membrane; cytoplasm; plasma membrane; protein binding; inflammatory response; positive regulation of NF-kappaB transcription factor activity; angiogenesis;
PIK3CG	7	cytoplasm; plasma membrane; protein binding; positive regulation of acute inflammatory response; inflammatory response; positive regulation of protein kinase B signaling cascade; angiogenesis;
ADORA2A	6	integral to plasma membrane; plasma membrane; protein binding; inflammatory response; negative regulation of neuron apoptotic process; positive regulation of protein secretion;
CCR5	6	integral to plasma membrane; cytoplasm; plasma membrane; protein binding; cell surface; inflammatory response;
MEP1B	6	integral to plasma membrane; proteolysis; plasma membrane; metalloendopeptidase activity; zinc ion binding; inflammatory response;
NRXN1	6	integral to plasma membrane; plasma membrane; protein binding; cell surface; cell adhesion molecule binding; angiogenesis;
PTPRJ	6	integral to plasma membrane; plasma membrane; protein binding; cell surface; positive regulation of cell adhesion; positive regulation of protein kinase B signaling cascade;
ASTL	6	proteolysis; cytoplasm; plasma membrane; metalloendopeptidase activity; positive regulation of protein processing; zinc ion binding;
MALT1	6	proteolysis; cytoplasm; plasma membrane; protein binding; protein self-association; positive regulation of NF-kappaB transcription factor activity;
TNFAIP3	6	proteolysis; cytoplasm; protein binding; zinc ion binding; inflammatory response; protein self-association;
SNCA	6	cytoplasm; plasma membrane; calcium ion binding; protein binding; zinc ion binding; negative regulation of neuron apoptotic process;
VEGFA	6	cytoplasm; protein binding; cell surface; positive regulation of cell adhesion; cellular response to hypoxia; angiogenesis;
ADRA2A	5	integral to plasma membrane; cytoplasm; plasma membrane; protein binding; positive regulation of membrane protein ectodomain proteolysis;
FZD4	5	integral to plasma membrane; cytoplasm; plasma membrane; protein binding; cell surface;
GRIN2A	5	integral to plasma membrane; plasma membrane; protein binding; zinc ion binding; cell surface;
GRIN2B	5	integral to plasma membrane; plasma membrane; protein binding; zinc ion binding; cell surface;
MC1R	5	integral to plasma membrane; cytoplasm; plasma membrane; protein binding; positive regulation of protein kinase B signaling cascade;
MMP24	5	integral to plasma membrane; proteolysis; calcium ion binding; metalloendopeptidase activity; zinc ion binding;
THY1	5	integral to plasma membrane; plasma membrane; protein binding; cell-cell adhesion; angiogenesis;
TLR4	5	integral to plasma membrane; cytoplasm; plasma membrane; protein binding; positive regulation of NF-kappaB transcription factor activity;
ADAMTS7	5	proteolysis; metalloendopeptidase activity; zinc ion binding; cell surface; metallopeptidase activity;
C9orf3	5	proteolysis; cytoplasm; metalloendopeptidase activity; zinc ion binding; metallopeptidase activity;
CAPN1	5	proteolysis; cytoplasm; plasma membrane; calcium ion binding; protein binding;
DPP3	5	proteolysis; cytoplasm; plasma membrane; zinc ion binding; metallopeptidase activity;
F10	5	proteolysis; plasma membrane; calcium ion binding; protein binding; positive regulation of protein kinase B signaling cascade;
MMP20	5	proteolysis; calcium ion binding; protein binding; metalloendopeptidase activity; zinc ion binding;
PYCARD	5	proteolysis; cytoplasm; protein binding; inflammatory response; positive regulation of NF-kappaB transcription factor activity;
CBL	5	cytoplasm; plasma membrane; calcium ion binding; protein binding; zinc ion binding;
DTNA	5	cytoplasm; plasma membrane; calcium ion binding; protein binding; zinc ion binding;
ILK	5	cytoplasm; plasma membrane; protein binding; negative regulation of neuron apoptotic process; positive regulation of protein kinase B signaling cascade;
LPXN	5	cytoplasm; plasma membrane; protein binding; zinc ion binding; podosome;
PRKCB	5	cytoplasm; plasma membrane; protein binding; zinc ion binding; positive regulation of NF-kappaB transcription factor activity;
STXBP3	5	cytoplasm; plasma membrane; protein binding; specific granule; tertiary granule;
TRIM32	5	cytoplasm; protein binding; zinc ion binding; protein self-association; positive regulation of NF-kappaB transcription factor activity;
ACHE	5	plasma membrane; protein binding; cell surface; protein self-association; positive regulation of protein secretion;

Genes shared at least 2 KEGG pathways with ADAM8 (count: 0)

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Region: chr10:135075907..135090407 View in gBrowse