Gene Report
Basic Info
Approved Symbol |
MC1R
|
Symbol Alias |
MSH-R |
Approved Name |
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
Location |
16q24.3 |
Position |
chr16:89984287-89987385, + |
External Links |
HGNC: 6929
Entrez Gene: 4157
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 23)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04080 |
Neuroactive ligand-receptor interaction |
93 |
|
hsa04916 |
Melanogenesis |
15 |
Cutaneous melanin pigment plays a critical role in camouflag......
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.
More...
|
Genes shared at least 5 GO terms with MC1R (count: 15)
Genes shared at least 2 KEGG pathways with MC1R (count: 0)
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