ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	OPRM1
Symbol Alias	MOR1
Approved Name	opioid receptor, mu 1
Location	6q24-q25
Position	chr6:154331631-154568001, +
External Links	HGNC: 8156 Entrez Gene: 4988 Ensembl: ENSG00000112038 UCSC: uc003qpo.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Carpentier, P. J., 2012	The OPRM1 risk genotype increased the risk for the combined ADHD and SUD phenotype.	Significant

Gene related SNPs (count: 10)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1799971	Chr6:154360797(Fwd)	NMD_transcript_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant	1(1/0/0)

LD-proxies (count: 9)

rs_ID	Location	Functional Annotation
rs1294086	Chr6:154337784(Fwd)	intron_variant
rs712244	Chr6:154335150(Fwd)	intron_variant
rs7757649	Chr6:154336687(Fwd)	intron_variant
rs1294087	Chr6:154337595(Fwd)	intron_variant
rs1294092	Chr6:154335673(Fwd)	intron_variant
rs3798683	Chr6:154418414(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs1294091	Chr6:154336426(Fwd)	intron_variant
rs9383689	Chr6:154329853(Fwd)	upstream_gene_variant
rs9285541	Chr6:154330629(Fwd)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process		20
GO:0007600	sensory perception	Biological Process	NAS[9689128]	5
GO:0007194	negative regulation of adenylate cyclase activity	Biological Process		10
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	Biological Process		12
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Biological Process		5
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	Biological Process		6
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7905839]	220
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[7905839]	18
GO:0005794	Golgi apparatus	Cellular Component	TAS[9242668]	157
GO:0005886	plasma membrane	Cellular Component		772
GO:0005515	protein binding	Molecular Function		910
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[9242668]	100
GO:0004979	beta-endorphin receptor activity	Molecular Function	IMP[9689128]	1
GO:0005245	voltage-gated calcium channel activity	Molecular Function		22
GO:0001965	G-protein alpha-subunit binding	Molecular Function		3
GO:0004930	G-protein coupled receptor activity	Molecular Function		236
GO:0045429	positive regulation of nitric oxide biosynthetic process	Biological Process		6
GO:0045019	negative regulation of nitric oxide biosynthetic process	Biological Process		1
GO:0050769	positive regulation of neurogenesis	Biological Process		4
GO:0048149	behavioral response to ethanol	Biological Process		4
GO:0051481	reduction of cytosolic calcium ion concentration	Biological Process		2
GO:0050795	regulation of behavior	Biological Process		3
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process		22
GO:0061358	negative regulation of Wnt protein secretion	Biological Process		1
GO:0007626	locomotory behavior	Biological Process		24
GO:0007610	behavior	Biological Process	NAS[9689128]	10
GO:0019233	sensory perception of pain	Biological Process		17
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS[2159143]	59
GO:0038047	morphine receptor activity	Molecular Function		1
GO:0033554	cellular response to stress	Biological Process		12
GO:0043951	negative regulation of cAMP-mediated signaling	Biological Process		1
GO:0043950	positive regulation of cAMP-mediated signaling	Biological Process		1
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	Biological Process		3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with OPRM1 (count: 16)

Gene Symbol	Pathway Count	Pathway List
DRD2	9	negative regulation of adenylate cyclase activity; integral to plasma membrane; plasma membrane; protein binding; behavioral response to ethanol; reduction of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; locomotory behavior; negative regulation of cell proliferation;
ADRA1A	6	elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; positive regulation of ERK1 and ERK2 cascade; negative regulation of cell proliferation;
LPAR1	6	elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; protein binding; G-protein alpha-subunit binding; G-protein coupled receptor activity;
ADORA2A	6	sensory perception; integral to plasma membrane; plasma membrane; protein binding; locomotory behavior; negative regulation of cell proliferation;
DRD3	6	negative regulation of adenylate cyclase activity; adenylate cyclase-activating dopamine receptor signaling pathway; integral to plasma membrane; plasma membrane; protein binding; locomotory behavior;
CCKBR	5	elevation of cytosolic calcium ion concentration; sensory perception; phospholipase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane;
EDNRA	5	elevation of cytosolic calcium ion concentration; integral to plasma membrane; plasma membrane; positive regulation of ERK1 and ERK2 cascade; sensory perception of pain;
S1PR3	5	elevation of cytosolic calcium ion concentration; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; G-protein coupled receptor activity;
NTSR2	5	sensory perception; phospholipase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; G-protein coupled receptor activity;
DRD4	5	negative regulation of adenylate cyclase activity; integral to plasma membrane; plasma membrane; protein binding; behavioral response to ethanol;
DRD1	5	adenylate cyclase-activating dopamine receptor signaling pathway; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; protein binding;
CNR1	5	integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; behavior; sensory perception of pain;
GJA1	5	integral to plasma membrane; Golgi apparatus; plasma membrane; protein binding; negative regulation of cell proliferation;
GRM1	5	integral to plasma membrane; plasma membrane; G-protein coupled receptor activity; locomotory behavior; sensory perception of pain;
MC1R	5	integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; protein binding; sensory perception of pain;
TLR4	5	integral to plasma membrane; plasma membrane; protein binding; positive regulation of nitric oxide biosynthetic process; positive regulation of ERK1 and ERK2 cascade;

Genes shared at least 2 KEGG pathways with OPRM1 (count: 0)

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Region: chr6:154331631..154568001 View in gBrowse