ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol DRD1
Approved Name dopamine receptor D1
Location 5q34-q35
Position chr5:174867042-174871211, -1
External Links HGNC: 3020
Entrez Gene: 1812
Ensembl: ENSG00000184845
UCSC: uc003mcz.3
No. of Studies 8 (significant: 5; non-significant: 3; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 8)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Wang G. X., 2012 SNP rs5326 mapped to this gene showed no association with ADHD in this study. Non-significant
Nyman ES, 2007 No evidence of association was seen. Non-significant
Bobb AJ, 2005 revealed significant association of two SNPs with ADHD Significant
Brookes K, 2006 UNPHASED TDT P-value=0.00847, global P-value=0.0454, WHAP TDT P_sum P-value=0.231, one or more SNPs with nominal P-value<0.05 located in this gene Significant
Misener VL, 2004 (a) TRANSMIT haplotype analysis: P=0.22 for GCAT, P=0.045 for CCAT, P=0.008 for GCAC; FBAT analysis of haplotype GCAC: P=0.024 for Parent-reported IN, P=0.03 for Teacher-reported IN, P=0.094 for Parent-reported HI, P=0.169 for Teacher-reported HI; Logistic regression analysis of haplotype GCAC (D1P.6 as proxy): P=0.008 (OR[95% CI]=1.230[1.034¨C1.462]) for Parent-reported IN, P=0.045 (OR[95% CI]=1.175[0.973¨C1.418]) for Teacher-reported IN, P=0.266 (OR[95% CI]=1.050[0.902¨C1.222]) for Parent-reported HI, P=0.259 (OR[95% CI]=0.952[0.821¨C1.104]) for Teacher-reported HI. These findings support the proposed involvement of DRD1 in ADHD. Significant
Oades RD, 2008 1 SNP showed significant association Significant
Kirley A, 2002 HHRR: P=0.64 (RR=1.06, OR=1.1); TDT: P=0.708 (OR=1.13); TDT by presence of family history: P=0.509 (OR[95%CI]=1.78[0.48-6.62]); TDT of Paternal and Maternal transmissions: P=0.78 (OR[95%CI]=0.85[0.26-2.78]). No preferential transmission of alleles to ADHD children was observed Non-significant
Ribases, M., 2012 The single- and multiple-marker analysis in both population and family-based approaches provided preliminary evidence for the contribution of DRD1 to combined-type ADHD in children (P=8.8e-04; OR=1.50 (1.18-1.90) and P=0.0061; OR=1.73 (1.23-2.45)) but not in adults. The replication of the association between DRD1 and ADHD in two European cohorts highlights the validity of our finding and supports the involvement of DRD1 in childhood ADHD. Significant

Gene related SNPs (count: 16)

Literature-origin SNPs (count: 10)

LD-proxies (count: 6)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Gene related regions (count: 0)

Gene related GO terms (count: 51)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 51)

Gene related KEGG pathways (count: 3)

Genes shared at least 5 GO terms with DRD1 (count: 27)

Genes shared at least 2 KEGG pathways with DRD1 (count: 38)

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Region: chr5:174867042..174871211 View in gBrowse
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