Reference |
Statistical Values/Author Comments |
Result of Statistical Analysis |
Langley K, 2003 |
TRANSMIT P-value=0.981 (simulated), X2=0.204, degrees of freedom=3; HAPMAX P-value=0.708 (simulated), X2=1.488, degrees of freedom=3; haplotype analysis using both HAPMAX and TRANSMIT showed no evidence of association |
Non-significant
|
Kent L, 2002 |
ETDT haplotype analysis: P=0.004 for Promoter/3'UTR, P=0.03 for VNTR/3'UTR. Current study demonstrated preferential transmission of the T allele of the 3' UTR polymorphism in the serotonin transporter in a sample of 113 ADHD trios in addition to preferential transmission of haplotypes containing the T allele of the 3' UTR, as well as the long allele of the promoter polymorphism (a finding also supported by the pooled analysis). |
Significant
|
Zoroglu SS, 2002 |
The lack of an S/S variant of 5-HTTLPR polymorphism of the STin2.12/12 variant of VNTR polymorphism appears to be associated with an increased risk of ADHD. |
Significant
|
Manor I, 2001 |
the results showed an association between the 5-HTTLPR polymorphism and ADHD |
Significant
|
Kim SJ, 2005 |
haplotype (5-HTTLPR/intron2 VNTR) global P-value=0.2 for ADHD pooled together, global P-value=0.07 for ADHD without ADHD NOS Subtype; failed to detect transmission disequilibrium |
Non-significant
|
Xu X, 2005(b) |
a three-marker haplotype, long-allele/9-repeat-allele/T-allele, ETDT: X2=4.5, P-value=0.034; HHRR: X2=3.6, P-value=0.058; TRANSMIT: X2=1.9, P-value=0.167; there was some evidence for preferential transmission in the UK sample, but no evidence in the Taiwanese sample or for association with other haplotypes |
Significant
|
Zhao AL, 2005 |
no significant associations were seen between 5-HTTLPR and ADHD |
Non-significant
|
Beitchman JH, 2003 |
5HTT VNTR polymorphism was significantly associated with aggressive behavior and 5HTTLPR was significantly associate with ADHD |
Significant
|
Brookes K, 2006 |
UNPHASED TDT P-value=0.194, global P-value=0.832, WHAP TDT P_sum P-value=0.295, no SNP with nominal P-value<0.05 located in this gene |
Non-significant
|
Wigg KG, 2006 |
no evidence of biased transmission of any of the polymorphisms and haplotypes was observed |
Non-significant
|
Banerjee E, 2006 |
Pair-wise combination of alleles comprising the 5-HTTLPR and STin2 polymorphic, X2 =14.74, df=1; P-value=0.0001 |
Significant
|
Hawi Z, 2005 |
one marker showed significant overtransmission of paternal alleles; paternal versus maternal transmissions, combined TDT P-value=0.0019, X2=9.6 (1df), OR=1.56; TDT P-value=0.0085, X2=6.9 when SERT was removed in sensitivity analysis |
Significant
|
Grevet EH, 2007 |
The 5-HTTLPR polymorphism was not associated with ADHD |
Non-significant
|
Heiser P, 2007 |
2 polymorphisms and 1 SNP showed no association to ADHD in their sample |
Non-significant
|
Guimaraes AP, 2007 |
No evidences for biased transmission of the allele for SLC6A4 polymorphism to the ADHD probands were observed. |
Non-significant
|
Li J, 2007 |
Haplotype TRANSMIT Analysis: global P-value=0.10 for ADHD, P-value=0.12 for ADHD-C, P-value=0.31 for ADHD-I; in ADHD, P-value=0.013 for haplotype L/10, P-value=0.027 for L/12; in ADHD-C, P-value=0.033 for L/12; in ADHD-I, P-value=0.110 for L/10. Preferential transmission of the S allele of the 5-HTTLPR polymorphism to probands with ADHD was found. L/10 haplotype was over-transmitted, while L/12 was under-transmitted to probands with ADHD. |
Significant
|
Spencer, T. J., 2012 |
the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups. |
Non-significant
|
Landaas ET, 2010 |
rs140700 was significantly associated in the Norwegian sample; 4 SNPs had significant associations with the Norwegian females; but meta-analysis refuted a strong effect |
Significant
|
Gizer IR, 2009 |
The present study provides significant evidence of an association between ADHD and the 5HTTLPR, but failed to detect an association with the STin2 and rs3813034 polymorphisms. |
Significant
|
Bidwell LC, 2011 |
The current study did not replicate previous associations with ADHD and the 5HTT gene. |
Non-significant
|
Ilott NE, 2010 |
2 SNPs showed modest, nominally significant association in the AW tests at age 3 |
Significant
|
Xu X, 2008(a) |
TDT P-value>0.05 of the haplotypes for 5-HTTLPR and STin2-VNTR Polymorphisms, not significantly associated with ADHD |
Non-significant
|
Nyman ES, 2007 |
Four SNPs in 5-HTT are nominally associated, including an SNP in the 3' flanking region (rs1979572) and three intronic SNPs. |
Significant
|
Oades RD, 2008 |
1 polymorphism showed significant association |
Significant
|
Biederman J, 2008 |
no SNP showed evidence of association |
Non-significant
|