ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SLC18A2
Previous Symbol	VMAT2
Symbol Alias	SVMT, SVAT
Approved Name	solute carrier family 18 (vesicular monoamine transporter), member 2
Location	10q25
Position	chr10:119000604-119038941, 1
External Links	HGNC: 10935 Entrez Gene: 6571 Ensembl: ENSG00000165646 UCSC: uc001ldd.2
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.084, global P-value=0.83, WHAP TDT P_sum P-value=0.212, no SNP with nominal P-value<0.05 located in this gene	Non-significant
Brookes KJ, 2005 (b)	no SNP showed evidence of association	Non-significant

Gene related SNPs (count: 7)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs363225	chr10:119024502(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

LD-proxies (count: 6)

rs_ID	Location	Functional Annotation
rs14240	chr10:119037071(Fwd)	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant
rs363223	chr10:119022561(Fwd)	intron_variant; nc_transcript_variant
rs363224	chr10:119022573(Fwd)	intron_variant; nc_transcript_variant
rs363230	chr10:119029515(Fwd)	intron_variant; nc_transcript_variant
rs10377	chr10:119037009(Fwd)	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant
rs2015586	chr10:119021737(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051412	response to corticosterone stimulus	biological process	IEA	5
GO:0042593	glucose homeostasis	biological process	IEA	21
GO:0042594	response to starvation	biological process	IEA	6
GO:0019899	enzyme binding	molecular function	IEA	54
GO:0016020	membrane	cellular component	TAS[8095030]	155
GO:0009635	response to herbicide	biological process	IEA	4
GO:0007626	locomotory behavior	biological process	IEA	26
GO:0043025	neuronal cell body	cellular component	IEA	56
GO:0032456	endocytic recycling	biological process	IEA	5
GO:0030672	synaptic vesicle membrane	cellular component	IEA	15
GO:0008504	monoamine transmembrane transporter activity	molecular function	TAS[8095030]	4
GO:0055085	transmembrane transport	biological process	TAS	95
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane	cellular component	TAS	3
GO:0030073	insulin secretion	biological process	IEA	7
GO:0043195	terminal bouton	cellular component	IEA	11
GO:0031072	heat shock protein binding	molecular function	IEA	12
GO:0008144	drug binding	molecular function	IEA	20
GO:0007268	synaptic transmission	biological process	TAS	103
GO:0009791	post-embryonic development	biological process	IEA	17
GO:0016265	death	biological process	IEA	2
GO:0015844	monoamine transport	biological process	TAS[8095030]	5
GO:0031045	dense core granule	cellular component	IEA	3
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0007269	neurotransmitter secretion	biological process	TAS	21
GO:0007568	aging	biological process	IEA	29
GO:0071242	cellular response to ammonium ion	biological process	IEA	1
GO:0005887	integral to plasma membrane	cellular component	TAS[8095030]	236
GO:0051589	negative regulation of neurotransmitter transport	biological process	IEA	1
GO:0042220	response to cocaine	biological process	IEA	11
GO:0035690	cellular response to drug	biological process	IEA	8
GO:0015222	serotonin transmembrane transporter activity	molecular function	IEA	2
GO:0010043	response to zinc ion	biological process	IEA	4
GO:0001975	response to amphetamine	biological process	IEA	16

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SLC18A2 (count: 21)

Gene Symbol	Pathway Count	Pathway List
SLC6A3	11	locomotory behavior; neuronal cell body; monoamine transmembrane transporter activity; transmembrane transport; drug binding; synaptic transmission; monoamine transport; plasma membrane; aging; integral to plasma membrane; response to cocaine;
TH	7	response to corticosterone stimulus; response to herbicide; locomotory behavior; terminal bouton; cellular response to drug; response to zinc ion; response to amphetamine;
ADORA2A	7	enzyme binding; membrane; locomotory behavior; neuronal cell body; plasma membrane; integral to plasma membrane; response to amphetamine;
DRD4	7	membrane; neuronal cell body; terminal bouton; drug binding; plasma membrane; integral to plasma membrane; response to amphetamine;
SLC6A1	7	membrane; transmembrane transport; synaptic transmission; plasma membrane; neurotransmitter secretion; integral to plasma membrane; response to cocaine;
SLC6A2	7	membrane; monoamine transmembrane transporter activity; transmembrane transport; synaptic transmission; monoamine transport; plasma membrane; integral to plasma membrane;
DRD2	7	locomotory behavior; synaptic vesicle membrane; drug binding; plasma membrane; integral to plasma membrane; response to cocaine; response to amphetamine;
DRD3	6	locomotory behavior; drug binding; plasma membrane; integral to plasma membrane; response to cocaine; response to amphetamine;
VAMP2	6	synaptic vesicle membrane; clathrin-sculpted monoamine transport vesicle membrane; synaptic transmission; plasma membrane; neurotransmitter secretion; integral to plasma membrane;
SYT1	6	synaptic vesicle membrane; clathrin-sculpted monoamine transport vesicle membrane; synaptic transmission; dense core granule; plasma membrane; neurotransmitter secretion;
DBH	5	glucose homeostasis; membrane; locomotory behavior; synaptic transmission; response to amphetamine;
CACNA1C	5	glucose homeostasis; neuronal cell body; insulin secretion; synaptic transmission; plasma membrane;
ADRA1B	5	glucose homeostasis; locomotory behavior; plasma membrane; integral to plasma membrane; response to amphetamine;
SLC1A3	5	membrane; neuronal cell body; transmembrane transport; synaptic transmission; plasma membrane;
CHRNA4	5	membrane; locomotory behavior; neuronal cell body; synaptic transmission; plasma membrane;
SLC5A7	5	neuronal cell body; transmembrane transport; synaptic transmission; plasma membrane; neurotransmitter secretion;
SLC6A4	5	monoamine transmembrane transporter activity; monoamine transport; plasma membrane; integral to plasma membrane; serotonin transmembrane transporter activity;
HTR1B	5	drug binding; synaptic transmission; plasma membrane; integral to plasma membrane; response to cocaine;
HTR2A	5	drug binding; synaptic transmission; plasma membrane; aging; integral to plasma membrane;
CNR1	5	drug binding; plasma membrane; aging; integral to plasma membrane; response to cocaine;
DRD5	5	synaptic transmission; plasma membrane; integral to plasma membrane; response to cocaine; response to amphetamine;

Genes shared at least 2 KEGG pathways with SLC18A2 (count: 0)

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Region: chr10:119000604..119038941 View in gBrowse