ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	VAMP2
Previous Symbol	SYB2
Symbol Alias	VAMP-2
Approved Name	vesicle-associated membrane protein 2 (synaptobrevin 2)
Location	17pter-p12
Position	chr17:8054134-8066864, -
External Links	HGNC: 12643 Entrez Gene: 6844 Ensembl: ENSG00000220205 UCSC: uc010cnt.1
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes KJ, 2005 (b)	no SNP showed evidence of association	Non-significant
Brookes K, 2006	UNPHASED TDT P-value=0.568, global P-value=0.924, WHAP TDT P_sum P-value=0.782, no SNP with nominal P-value<0.05 located in this gene	Non-significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs316987	Chr1:105047523(Fwd)		1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function		910
GO:0005886	plasma membrane	Cellular Component		772
GO:0006892	post-Golgi vesicle-mediated transport	Biological Process		16
GO:0007268	synaptic transmission	Biological Process		96
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1976629]	220
GO:0006112	energy reserve metabolic process	Biological Process		25
GO:0030666	endocytic vesicle membrane	Cellular Component		11
GO:0030136	clathrin-coated vesicle	Cellular Component	IDA[19478182]	9
GO:0030672	synaptic vesicle membrane	Cellular Component		15
GO:0030667	secretory granule membrane	Cellular Component		5
GO:0014047	glutamate secretion	Biological Process		7
GO:0007269	neurotransmitter secretion	Biological Process		18
GO:0030054	cell junction	Cellular Component		77
GO:0016044	cellular membrane organization	Biological Process		24
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	Cellular Component		3
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane	Cellular Component		2
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane	Cellular Component		3
GO:0043005	neuron projection	Cellular Component		35
GO:0031201	SNARE complex	Cellular Component	IDA[19546860]	13
GO:0050796	regulation of insulin secretion	Biological Process		22
GO:0044281	small molecule metabolic process	Biological Process		248

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04962	Vasopressin-regulated water reabsorption	6	In the kidney, the antidiuretic hormone vasopressin (AVP) is...... In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again. More...
hsa04130	SNARE interactions in vesicular transport	20
hsa04970	Salivary secretion	22	Saliva has manifold functions in maintaining the integrity o...... Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP. More...

Genes shared at least 5 GO terms with VAMP2 (count: 21)

Gene Symbol	Pathway Count	Pathway List
STX1A	12	protein binding; plasma membrane; synaptic transmission; energy reserve metabolic process; synaptic vesicle membrane; glutamate secretion; neurotransmitter secretion; cell junction; neuron projection; SNARE complex; regulation of insulin secretion; small molecule metabolic process;
SYT1	12	protein binding; plasma membrane; synaptic transmission; endocytic vesicle membrane; synaptic vesicle membrane; glutamate secretion; neurotransmitter secretion; cell junction; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; clathrin-sculpted glutamate transport vesicle membrane; clathrin-sculpted monoamine transport vesicle membrane; neuron projection;
SNAP25	11	protein binding; plasma membrane; synaptic transmission; energy reserve metabolic process; glutamate secretion; neurotransmitter secretion; cell junction; neuron projection; SNARE complex; regulation of insulin secretion; small molecule metabolic process;
HSPA8	7	protein binding; plasma membrane; post-Golgi vesicle-mediated transport; synaptic transmission; neurotransmitter secretion; cellular membrane organization; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;
SYT2	7	protein binding; plasma membrane; synaptic transmission; endocytic vesicle membrane; synaptic vesicle membrane; neurotransmitter secretion; cell junction;
ADRA2A	6	protein binding; plasma membrane; integral to plasma membrane; energy reserve metabolic process; regulation of insulin secretion; small molecule metabolic process;
ADRA2C	6	protein binding; plasma membrane; integral to plasma membrane; energy reserve metabolic process; regulation of insulin secretion; small molecule metabolic process;
CACNA1A	6	protein binding; plasma membrane; synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; small molecule metabolic process;
CACNA1C	6	protein binding; plasma membrane; synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; small molecule metabolic process;
GRIN2B	6	protein binding; plasma membrane; synaptic transmission; integral to plasma membrane; cell junction; neuron projection;
SNAP23	6	protein binding; plasma membrane; post-Golgi vesicle-mediated transport; cell junction; cellular membrane organization; neuron projection;
CHRM3	6	plasma membrane; integral to plasma membrane; energy reserve metabolic process; cell junction; regulation of insulin secretion; small molecule metabolic process;
SLC18A2	6	plasma membrane; synaptic transmission; integral to plasma membrane; synaptic vesicle membrane; neurotransmitter secretion; clathrin-sculpted monoamine transport vesicle membrane;
ACHE	5	protein binding; plasma membrane; synaptic transmission; cell junction; small molecule metabolic process;
ADCY4	5	protein binding; plasma membrane; synaptic transmission; energy reserve metabolic process; small molecule metabolic process;
DOC2A	5	protein binding; synaptic transmission; synaptic vesicle membrane; cell junction; neuron projection;
GRIN2A	5	protein binding; plasma membrane; synaptic transmission; integral to plasma membrane; cell junction;
NRXN1	5	protein binding; plasma membrane; integral to plasma membrane; neurotransmitter secretion; cell junction;
STX4	5	protein binding; plasma membrane; post-Golgi vesicle-mediated transport; cellular membrane organization; SNARE complex;
CACNA1E	5	plasma membrane; synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; small molecule metabolic process;
GABBR2	5	plasma membrane; synaptic transmission; integral to plasma membrane; cell junction; neuron projection;

Genes shared at least 2 KEGG pathways with VAMP2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
STX4	2	Vasopressin-regulated water reabsorption; SNARE interactions in vesicular transport;

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Region: chr17:8054134..8066864 View in gBrowse