ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol SNAP25
Previous Symbol SNAP
Symbol Alias SNAP-25, RIC-4, RIC4, SEC9, bA416N4.2, dJ1068F16.2
Approved Name synaptosomal-associated protein, 25kDa
Previous Name "synaptosomal-associated protein, 25kD"
Name Alias "resistance to inhibitors of cholinesterase 4 homolog"
Location 20p12-p11.2
Position chr20:10199478-10288066, 1
External Links HGNC: 11132
Entrez Gene: 6616
Ensembl: ENSG00000132639
UCSC: uc002wnr.2
No. of Studies 21 (significant: 16; non-significant: 5; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 21)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Kustanovich V, 2003 haplotype TDT P-value=0.027 for paternal transmission, there was a trend consistent with biased transmission of the TC haplotype of SNAP-25 in all transmissions and detected a significant distortion when paternal transmissions were evaluated Significant
Kim JW, 2007 Combined TDT of haplotype defined by rs3746544 & rs1051312: global P-value=0.01 (OR=1.36) | Haplotype association tests for co-morbidities of ADHD: smallest global P-value=0.013 for co-morbid MDD of ADHD. Several SNPs in this gene are significant or trend associated with ADHD or co-morbid MDD of ADHD. A haplotype block of the gene showed positive evidence for association with co-morbid MDD of ADHD. Significant
Hawi, Z.,2013 TDT analyses of all individual SNPs showed that there are two SNPs rs6108461 and rs362990 significant nominal association with ADHD.Permutation testing (10,000 permutations) revealed that only rs362990 (p-corrected=0.019) was associated with ADHD, with a trend towards association for rs6108461 (p-corrected=0.059). Significant
Guan L, 2009 haplotype association analysis: Nominal P-value=0.021, Empirical P-value=0.378 for ADHD | Nominal P-value=0.032, Empirical P-value=0.491 for ADHD-I | Nominal P-value=0.023, Empirical P-value=0.396 for ADHD-C. 5 SNPs in this gene achieved nominal significance for ADHD/ADHD-I/ADHD-C, and haplotype association test also achieved nominal significance for ADHD and both of subtypes. Significant
Gizer IR, 2009 The 3' UTR SNP rs3746544 yielded evidence of a modest but significant association between childhood ADHD and SNAP-25. Significant
Galvez, J. M.,2013 We found a significant association with the GT haplotype (rs3746554|rs1051312) of SNAP25 (p = 0.001). Evidence of association was also found for the G/G genotype of rs3746554 (p = 0.002) and C/C genotype of rs1051312 (p = 0.009). This is the first study in a Latin American population. Similar to other studies, we found evidence of the association of SNAP25 and ADHD. Significant
Feng Y, 2005(b) there was significant evidence for biased transmission of the alleles of four polymorphisms; haplotype analyses did not reveal any association more informative than single-marker analysis in the Toronto sample and no significant association was identified in the Irvine sample; the findings supported SNAP25 in the susceptibility to ADHD Significant
Choi TK, 2007 rs3746544 was significantly associated with ADHD in this study Significant
Brophy K, 2002 increased preferential transmission of SNAP-25/DdeI allelel to ADHD cases was found Significant
Brookes K, 2006 UNPHASED TDT P-value=0.0346, global P-value=0.529, WHAP TDT P_sum P-value=0.239; OR=1.29, one or more SNPs with nominal P-value<0.05 located in this gene Significant
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Barr CL, 2000 (a) TDT of haplotype: P=0.056 for haplotype TT; P=0.030 for haplotype TC; P=1.000 for haplotype GT. The haplotype of the absence of the site for the MnlI polymorphism (T, allele 1) and the presence of the DdeI site (C, allele 2) was significant Significant
Ilott NE, 2010 no SNP showed modest, nominally significant association Non-significant
Hawi Z, 2005 paternal versus maternal transmissions, 9 genes combined TDT P-value=0.0019, X2=9.6 (1df), OR=1.56; TDT P-value=0.007, X2=7.3 when SNAP-25 was removed in sensitivity analysis Non-significant
Renner TJ, 2008 pair-wise D' values=0.88 (for rs6077690 and rs6039769); pair-wise D' values=0.32 (for rs6077690 and rs363006); pair-wise D' values=0.77 (for rs6039769 and rs363006); haplotype P-value=0.89; no transmission disequilibrium in single nor haplotype analysis Non-significant
Nyman ES, 2007 No evidence of association was seen. Non-significant
Zhang HY, 2011 a significant association was identified between SNPrs362549 and ADHD subtypes, and the result shows that SNAP-25 is a genetic susceptibility factor for ADHD Significant
Pazvantoglu, O.,2013 SNAP-25 rs3746544 T allele and the NET1 rs2242447 C allele: P-value=0.007, X2=9.963, df=2 among groups; P-value=0.009, X2=6.901, df=1 between the ADHD and HC groups; P-value=0.005, X2=7.997, df=1 between the ADHD and the Non-ADHD groups. We found that even if variation in the SNAP-25 gene alone does not affect the phenotype, it may nevertheless lead to the emergence of a clinical ADHD picture in the presence of other genetic factors. Our findings suggest that a combination of NET1 (rs2242447) and SNAP-25 (rs3746544) is a risk factor for ADHD. Problems associated with the noradrenergic and serotonergic systems and SNAP-25 may play a role, both alone and in interaction with one another, in the pathophysiological mechanisms of ADHD. Significant
Sarkar, K., 2012 Haplotypes formed between rs362569 'T', 362988 'G', rs3746544 'T', rs1051312 'T' and rs8636 'C' in different combinations showed statistically significant transmission to ADHD probands. Excepting rs3746544 and rs8636, all the tested sites showed very low linkage disequilibrium between them. Data obtained in this preliminary study indicates that rs3746544 'T' allele may have some role in the disease etiology in the studied Indian population. Significant
Mill J, 2002 The data from both analyses suggest that SNAP-25 may play a role in the genetic etiology of ADHD. Significant
Mill J, 2004 (b) 3 variants were significantly associated with ADHD in this study; the most significant haplotype G-4-G, TDT P-value=0.05 for the third haplotype window; the most significant haplotype 4-G-T, TDT P-value=0.04 for the fourth haplotype window; the most significant haplotype G-T-T, TDT P-value=0.04 for the fifth haplotype window; the most significant haplotype T-T-C, TDT P-value=0.03 for the sixth haplotype window; global TDT P-value=0.001 of a three-marker haplotype gave individual significant evidence for association with ADHD; two-marker haplotype (87610T/G and 87614T/C) TDT P-value=0.01, X2=6.22 showed some suggestive evidence for haplotypes of these SNPs being involved in ADHD with the T-T haplotype being over transmitted to ADHD probands Significant

Gene related SNPs (count: 115)

Literature-origin SNPs (count: 47)

LD-proxies (count: 68)


Gene related CNVs (count: 0)

Gene related other variant (count: 9)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)


Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with SNAP25 (count: 39)

Genes shared at least 2 KEGG pathways with SNAP25 (count: 0)

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Region: chr20:10199478..10288066 View in gBrowse
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