ADHDgene Database

SNP Report

Basic Info

Name	rs1889189 dbSNP Ensembl
Location	Chr20:10197086(Fwd)
Variant Alleles	T/C
Ancestral Allele	C
Functional Annotation	intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000451151; ENST00000453544; ENST00000421143; ENST00000426491) nc_transcript_variant(ENST00000451151; ENST00000453544; ENST00000421143; ENST00000426491) upstream_gene_variant(ENST00000304886; ENST00000254976; ENST00000430336)
No. of Studies	3 (significant: 0; non-significant: 3; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/G	UNPHASED TDT P-value=0.835; WHAP TDT P-value=0.393 UNPHASED TDT P-value=0.835; WHAP TDT P-value=0.393	no significant association was observed no significant association was observed	Non-significant
Sarkar, K., 2012	C/T	allelic P-value=0.47, X²=0.52 for case-control, P...... allelic P-value=0.47, X²=0.52 for case-control, P-value=0.39, X²=0.75 for family-based; genotypic P-value=0.29, X²=2.47 for case-control, P-value=0.13, X²=4.13 for family-based More...	Case-control analysis revealed lack of any significant diffe...... Case-control analysis revealed lack of any significant difference in allelic frequencies between ADHD probands, their parents and controls P>0.05. More...	Non-significant
Feng Y, 2005(b)	T/C	allelic TDT P-value=0.508, X²=0.439 in Irvine sam...... allelic TDT P-value=0.508, X²=0.439 in Irvine sample; allelic TDT P-value=0.084, X²=2.988 in Toronto sample More...	there was no significant result both in the Toronto sample a...... there was no significant result both in the Toronto sample and the Irvine sample More...	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	18(13/5/0)

Approved Symbol	Approved Name	Location
SNAP25-AS1	SNAP25 antisense RNA 1	20p12.2

SNPs in LD with rs1889189 (count: 13) View in gBrowse (chr20:10169643..10198954 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6039769	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)	1.0[ASW]; 0.817[CEU]; 0.944[TSI]

rs_ID	Functional Annotation	r²[population]
rs2026538	intron_variant; nc_transcript_variant	0.824[CHB]
rs6039759	downstream_gene_variant; intron_variant; nc_transcript_variant	0.825[CHB]; 0.809[CHD]
rs4813921	intron_variant; nc_transcript_variant	1.0[CEU]; 0.825[CHB]; 0.833[CHD]; 0.89[JPT]; 1.0[MEX]; 0.916[TSI]
rs6032824	intron_variant; nc_transcript_variant	1.0[CEU]; 0.911[CHB]; 0.882[JPT]
rs6039764	intron_variant; nc_transcript_variant	0.906[CEU]; 0.825[CHB]; 0.89[JPT]
rs2026537	intron_variant; nc_transcript_variant	0.825[CHB]
rs6032821	intron_variant; nc_transcript_variant	0.825[CHB]; 0.809[CHD]; 0.836[JPT]
rs6039762	downstream_gene_variant; intron_variant; nc_transcript_variant	0.825[CHB]
rs6039758	downstream_gene_variant; intron_variant; nc_transcript_variant	0.825[CHB]; 0.89[JPT]
rs2327262	downstream_gene_variant; intron_variant; nc_transcript_variant	0.803[CHD]
rs2327263	intron_variant; nc_transcript_variant	0.906[CEU]; 0.825[CHB]; 0.809[CHD]; 0.89[JPT]; 1.0[MEX]; 0.916[TSI]
rs6039763	intron_variant; nc_transcript_variant	0.813[CHB]; 0.808[CHD]