ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SNPH
Symbol Alias	bA314N13.5
Approved Name	syntaphilin
Location	20p13
Position	chr20:1246960-1289972, +
External Links	HGNC: 15931 Entrez Gene: 9751 Ensembl: ENSG00000101298 UCSC: uc002wes.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Sanchez-Mora, C., 2012	nominal differences were found with children ADHD.	Significant

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6134520	Chr20:1288223(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(1/0/0)
rs3764715	Chr20:1287051(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs3795141	Chr20:1281004(Fwd)	downstream_gene_variant; intron_variant
rs3795142	Chr20:1280995(Fwd)	downstream_gene_variant; intron_variant
rs2317645	Chr20:1279336(Fwd)	downstream_gene_variant; intron_variant
rs6109320	Chr20:1277157(Fwd)	downstream_gene_variant; intron_variant
rs2273957	Chr20:1291778(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs11449	Chr20:1291018(Fwd)	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant
rs3795139	Chr20:1285933(Fwd)	downstream_gene_variant; synonymous_variant
rs912108	Chr20:1272405(Fwd)	intron_variant
rs966846	Chr20:1266403(Fwd)	intron_variant
rs3818331	Chr20:1281685(Fwd)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0005575	cellular_component	Cellular Component		98
GO:0043025	neuronal cell body	Cellular Component		51
GO:0007420	brain development	Biological Process		33
GO:0007269	neurotransmitter secretion	Biological Process	NAS[10707983]	18
GO:0016081	synaptic vesicle docking involved in exocytosis	Biological Process	NAS[10707983]	3
GO:0031966	mitochondrial membrane	Cellular Component		12
GO:0016021	integral to membrane	Cellular Component		845
GO:0030182	neuron differentiation	Biological Process		9
GO:0030054	cell junction	Cellular Component		77
GO:0043005	neuron projection	Cellular Component		35
GO:0017075	syntaxin-1 binding	Molecular Function	NAS[10707983]	8
GO:0042734	presynaptic membrane	Cellular Component		15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SNPH (count: 4)

Gene Symbol	Pathway Count	Pathway List
SYT1	7	plasma membrane; neurotransmitter secretion; integral to membrane; cell junction; neuron projection; syntaxin-1 binding; presynaptic membrane;
STX1A	6	plasma membrane; neurotransmitter secretion; synaptic vesicle docking involved in exocytosis; integral to membrane; cell junction; neuron projection;
NRXN1	5	plasma membrane; neurotransmitter secretion; integral to membrane; cell junction; presynaptic membrane;
SNAP25	5	plasma membrane; neurotransmitter secretion; synaptic vesicle docking involved in exocytosis; cell junction; neuron projection;

Genes shared at least 2 KEGG pathways with SNPH (count: 0)

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Region: chr20:1246960..1289972 View in gBrowse