ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0030054
Name cell junction
Type cellular component
No. of Genes in ADHDgene  84
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 84)

Literature-origin genes (count: 27)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
SYT1 synaptotagmin I 12q21.2 4(2/2/0) IEA
DISC1 disrupted in schizophrenia 1 1q42.1 1(1/0/0) IEA
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 2(0/1/1) IEA
SYP synaptophysin Xp11.23-p11.22 4(4/0/0) IEA
GRIK4 glutamate receptor, ionotropic, kainate 4 11q23.3 1(0/1/0) IEA
BAIAP2 BAI1-associated protein 2 17q25 1(1/0/0) IDA
FAIM2 Fas apoptotic inhibitory molecule 2 12q13 1(0/1/0) IEA
CPLX4 complexin 4 18q21.32 1(1/0/0) IEA
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0) IEA
SNPH syntaphilin 20p13 1(1/0/0) IEA
DACT1 dishevelled-binding antagonist of beta-catenin 1 14q22.3 1(0/1/0) IEA
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 4(1/3/0) IEA
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 1(0/1/0) IEA
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17p13.1 2(0/2/0) IEA
NRXN1 neurexin 1 2p16.3 1(0/1/0) IEA
GRIK1 glutamate receptor, ionotropic, kainate 1 21q22 1(0/0/1) IEA
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 2(1/1/0) IEA
CADM2 cell adhesion molecule 2 3p12.2 1(1/0/0) IEA
MAP1B microtubule-associated protein 1B 5q13 1(0/0/1) IEA
SYT2 synaptotagmin II 1q32.1 1(1/0/0) IEA
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 4p12 1(0/0/1) IEA
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 7(4/3/0) IEA
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0) IEA
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 11q23.1-q23.2 1(0/1/0) IEA
SYN3 synapsin III 22q12.3 2(1/1/0) IEA
SNAP25 synaptosomal-associated protein, 25kDa 20p12-p11.2 21(16/5/0) IEA
GRID2 glutamate receptor, ionotropic, delta 2 4q22 1(0/0/1) IEA

Genes from other sources Help (count: 57)

Approved Symbol Approved Name Source Evidence[PMID]
SYT9 synaptotagmin IX Mapped by CNV IEA
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 Mapped by CNV; Mapped by significant region IEA
CYFIP1 cytoplasmic FMR1 interacting protein 1 Mapped by significant region IEA
ACHE acetylcholinesterase (Yt blood group) Mapped by PBA pathway IEA
SYT10 synaptotagmin X Mapped by CNV IEA
RAPSN receptor-associated protein of the synapse Mapped by LD-proxy IEA
PRRT2 proline-rich transmembrane protein 2 Mapped by CNV IEA
PICK1 protein interacting with PRKCA 1 Mapped by Literature SNP IEA
CDK5RAP2 CDK5 regulatory subunit associated protein 2 Mapped by significant region IDA
SYT4 synaptotagmin IV Mapped by significant region IEA
ARHGAP32 Rho GTPase activating protein 32 Mapped by significant region IEA
SNAP23 synaptosomal-associated protein, 23kDa Mapped by PBA pathway IEA
TBC1D2 TBC1 domain family, member 2 Mapped by significant region IDA
UNC13C unc-13 homolog C (C. elegans) Mapped by CNV IEA
FERMT3 fermitin family member 3 Mapped by significant region IEA
DOC2A double C2-like domains, alpha Mapped by CNV IEA
EGFLAM EGF-like, fibronectin type III and laminin G domains Mapped by significant region IEA
P2RX6 purinergic receptor P2X, ligand-gated ion channel, 6 Mapped by CNV IDA[12088286]
SYT7 synaptotagmin VII Mapped by significant region IEA
MUSK muscle, skeletal, receptor tyrosine kinase Mapped by significant region IEA
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) Mapped by significant region IEA
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 Mapped by PBA pathway IEA
SIGMAR1 sigma non-opioid intracellular receptor 1 Mapped by LD-proxy IEA
GPR142 G protein-coupled receptor 142 Mapped by CNV IDA
SYNGR3 synaptogyrin 3 Mapped by significant region IEA
TRPV1 transient receptor potential cation channel, subfamily V, member 1 Mapped by PBA pathway IEA
DENND1A DENN/MADD domain containing 1A Mapped by significant region IEA
SHANK2 SH3 and multiple ankyrin repeat domains 2 Mapped by significant region IEA
PSD3 pleckstrin and Sec7 domain containing 3 Mapped by Literature SNP IBA
DTNA dystrobrevin, alpha Mapped by significant region IEA
SHISA9 shisa family member 9 Mapped by significant region IEA
CHRM5 cholinergic receptor, muscarinic 5 Mapped by CNV; Mapped by PBA pathway IEA
DLG2 discs, large homolog 2 (Drosophila) Mapped by significant region IEA
TJP1 tight junction protein 1 Mapped by CNV; Mapped by significant region IDA
CBLN3 cerebellin 3 precursor Mapped by significant region IEA
SV2C synaptic vesicle glycoprotein 2C Mapped by CNV IEA
CNIH2 cornichon family AMPA receptor auxiliary protein 2 Mapped by significant region IEA
AMOTL1 angiomotin like 1 Mapped by significant region IDA
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 Mapped by CNV; Mapped by significant region IEA
GOPC golgi-associated PDZ and coiled-coil motif containing Mapped by significant region IEA
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) Mapped by LD-proxy IEA
GRIA4 glutamate receptor, ionotropic, AMPA 4 Mapped by significant region IEA
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase Mapped by significant region IEA
SNAP29 synaptosomal-associated protein, 29kDa Mapped by CNV IEA
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 Mapped by CNV; Mapped by significant region IEA
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 Mapped by significant region IEA
CYFIP2 cytoplasmic FMR1 interacting protein 2 Mapped by significant region IEA
SYT12 synaptotagmin XII Mapped by significant region IEA
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway IEA
FRRS1L ferric-chelate reductase 1-like Mapped by significant region IEA
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Mapped by significant region IEA
NLGN1 neuroligin 1 Mapped by CNV IEA
CHRM1 cholinergic receptor, muscarinic 1 Mapped by significant region; Mapped by PBA pathway IEA
EPB41L2 erythrocyte membrane protein band 4.1-like 2 Mapped by significant region IDA
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 Mapped by significant region IEA
PERP PERP, TP53 apoptosis effector Mapped by significant region IDA
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) Mapped by LD-proxy IEA