ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STX1A
Previous Symbol	STX1
Symbol Alias	HPC-1, p35-1
Approved Name	syntaxin 1A (brain)
Location	7q11.2
Position	chr7:73113535-73134017, -
External Links	HGNC: 11433 Entrez Gene: 6804 Ensembl: ENSG00000106089 UCSC: uc003tyx.2
No. of Studies	3 (significant: 2; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 3)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Sanchez-Mora, C., 2012	STX1A was found associated with ADHD only in adults (p=0.0041; OR=1.28 (1.08-1.51))	Significant
Brookes K, 2006	UNPHASED TDT P-value=0.146, global P-value=0.485, WHAP TDT P_sum P-value=0.192, no SNP with nominal P-value<0.05 located in this gene	Non-significant
Brookes KJ, 2005 (b)	1 SNP showed nominal significance in TDT analysis	Significant

Gene related SNPs (count: 10)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1569061	Chr7:73114481(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1(1/0/0)
rs4363087	Chr7:73118196(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(1/0/0)
rs941298	Chr7:73125263(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)
rs3793243	Chr7:73121347(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)
rs2228607	Chr7:73122923(Fwd)	downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 5)

rs_ID	Location	Functional Annotation
rs941299	Chr7:73125179(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs4717806	Chr7:73116477(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs867500	Chr7:73114440(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs7778762	Chr7:73110832(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs1001220	Chr7:73110603(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 35)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 35)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043005	neuron projection	Cellular Component	IDA[12115694]	35
GO:0042641	actomyosin	Cellular Component		1
GO:0032028	myosin head/neck binding	Molecular Function		1
GO:0031201	SNARE complex	Cellular Component	IDA[19546860]	13
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0045921	positive regulation of exocytosis	Biological Process		5
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043008	ATP-dependent protein binding	Molecular Function		2
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	Cellular Component		3
GO:0050796	regulation of insulin secretion	Biological Process		22
GO:0048306	calcium-dependent protein binding	Molecular Function		5
GO:0047485	protein N-terminus binding	Molecular Function		23
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	Cellular Component		2
GO:0001948	glycoprotein binding	Molecular Function		3
GO:0000149	SNARE binding	Molecular Function		6
GO:0005484	SNAP receptor activity	Molecular Function		13
GO:0001956	positive regulation of neurotransmitter secretion	Biological Process		2
GO:0005576	extracellular region	Cellular Component		240
GO:0005515	protein binding	Molecular Function	IPI[10321247]	910
GO:0005886	plasma membrane	Cellular Component		772
GO:0006112	energy reserve metabolic process	Biological Process		25
GO:0006886	intracellular protein transport	Biological Process		43
GO:0007268	synaptic transmission	Biological Process		96
GO:0007269	neurotransmitter secretion	Biological Process		18
GO:0009629	response to gravity	Biological Process		2
GO:0014047	glutamate secretion	Biological Process		7
GO:0016021	integral to membrane	Cellular Component		845
GO:0016081	synaptic vesicle docking involved in exocytosis	Biological Process		3
GO:0017156	calcium ion-dependent exocytosis	Biological Process		2
GO:0019855	calcium channel inhibitor activity	Molecular Function		2
GO:0019904	protein domain specific binding	Molecular Function		40
GO:0030054	cell junction	Cellular Component		77
GO:0030141	secretory granule	Cellular Component		17
GO:0030672	synaptic vesicle membrane	Cellular Component		15
GO:0030674	protein binding, bridging	Molecular Function		11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04130	SNARE interactions in vesicular transport	20

Genes shared at least 5 GO terms with STX1A (count: 35)

Gene Symbol	Pathway Count	Pathway List
SNAP25	14	neuron projection; SNARE complex; small molecule metabolic process; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; regulation of insulin secretion; SNARE binding; protein binding; plasma membrane; energy reserve metabolic process; synaptic transmission; neurotransmitter secretion; glutamate secretion; synaptic vesicle docking involved in exocytosis; cell junction;
VAMP2	12	neuron projection; SNARE complex; small molecule metabolic process; regulation of insulin secretion; protein binding; plasma membrane; energy reserve metabolic process; synaptic transmission; neurotransmitter secretion; glutamate secretion; cell junction; synaptic vesicle membrane;
SYT1	10	neuron projection; calcium-dependent protein binding; protein binding; plasma membrane; synaptic transmission; neurotransmitter secretion; glutamate secretion; integral to membrane; cell junction; synaptic vesicle membrane;
CACNA1C	8	small molecule metabolic process; regulation of insulin secretion; protein binding; plasma membrane; energy reserve metabolic process; synaptic transmission; integral to membrane; calcium ion-dependent exocytosis;
STX4	7	SNARE complex; SNARE binding; SNAP receptor activity; protein binding; plasma membrane; intracellular protein transport; integral to membrane;
CACNA1A	7	small molecule metabolic process; regulation of insulin secretion; protein binding; plasma membrane; energy reserve metabolic process; synaptic transmission; integral to membrane;
SNCA	7	protein N-terminus binding; positive regulation of neurotransmitter secretion; extracellular region; protein binding; plasma membrane; protein domain specific binding; cell junction;
SYT2	7	protein binding; plasma membrane; synaptic transmission; neurotransmitter secretion; integral to membrane; cell junction; synaptic vesicle membrane;
SNPH	6	neuron projection; plasma membrane; neurotransmitter secretion; integral to membrane; synaptic vesicle docking involved in exocytosis; cell junction;
STX3	6	neuron projection; SNARE complex; SNAP receptor activity; protein binding; intracellular protein transport; integral to membrane;
STX6	6	SNARE complex; SNAP receptor activity; protein binding; plasma membrane; intracellular protein transport; integral to membrane;
ADRA2A	6	protein heterodimerization activity; small molecule metabolic process; regulation of insulin secretion; protein binding; plasma membrane; energy reserve metabolic process;
ADRA2C	6	protein heterodimerization activity; small molecule metabolic process; regulation of insulin secretion; protein binding; plasma membrane; energy reserve metabolic process;
ACHE	6	small molecule metabolic process; extracellular region; protein binding; plasma membrane; synaptic transmission; cell junction;
ADCY4	6	small molecule metabolic process; protein binding; plasma membrane; energy reserve metabolic process; synaptic transmission; integral to membrane;
INS	6	small molecule metabolic process; regulation of insulin secretion; extracellular region; protein binding; energy reserve metabolic process; secretory granule;
NRXN1	6	calcium-dependent protein binding; protein binding; plasma membrane; neurotransmitter secretion; integral to membrane; cell junction;
DOC2A	5	neuron projection; protein binding; synaptic transmission; cell junction; synaptic vesicle membrane;
GRIN2B	5	neuron projection; protein binding; plasma membrane; synaptic transmission; cell junction;
SYT4	5	neuron projection; neurotransmitter secretion; integral to membrane; cell junction; synaptic vesicle membrane;
STX16	5	SNARE complex; SNAP receptor activity; protein binding; intracellular protein transport; integral to membrane;
STX17	5	SNARE complex; SNARE binding; SNAP receptor activity; intracellular protein transport; integral to membrane;
STX5	5	SNARE complex; protein N-terminus binding; SNAP receptor activity; intracellular protein transport; integral to membrane;
STX7	5	SNARE complex; SNARE binding; SNAP receptor activity; intracellular protein transport; integral to membrane;
ALG2	5	protein heterodimerization activity; calcium-dependent protein binding; protein N-terminus binding; protein binding; integral to membrane;
KCNIP1	5	protein heterodimerization activity; protein N-terminus binding; protein binding; plasma membrane; synaptic transmission;
APOA1	5	small molecule metabolic process; extracellular region; protein binding; plasma membrane; secretory granule;
CACNA1E	5	small molecule metabolic process; regulation of insulin secretion; plasma membrane; energy reserve metabolic process; synaptic transmission;
CHRM3	5	small molecule metabolic process; regulation of insulin secretion; plasma membrane; energy reserve metabolic process; cell junction;
DBH	5	small molecule metabolic process; extracellular region; synaptic transmission; integral to membrane; secretory granule;
ITPR1	5	small molecule metabolic process; regulation of insulin secretion; protein binding; energy reserve metabolic process; integral to membrane;
ITPR2	5	small molecule metabolic process; regulation of insulin secretion; plasma membrane; energy reserve metabolic process; integral to membrane;
PRKAR2B	5	small molecule metabolic process; regulation of insulin secretion; plasma membrane; energy reserve metabolic process; protein domain specific binding;
SYT7	5	regulation of insulin secretion; plasma membrane; integral to membrane; cell junction; synaptic vesicle membrane;
SLC6A3	5	protein N-terminus binding; protein binding; plasma membrane; synaptic transmission; integral to membrane;

Genes shared at least 2 KEGG pathways with STX1A (count: 0)

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Region: chr7:73113535..73134017 View in gBrowse