ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SYT2
Approved Name	synaptotagmin II
Location	1q32.1
Position	chr1:202559724-202679551, -
External Links	HGNC: 11510 Entrez Gene: 127833 Ensembl: ENSG00000143858 UCSC: uc010pqb.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Sanchez-Mora, C., 2012	the SYT2 gene was strongly associated with both adulthood and childhood ADHD (p=0.001, OR=1.49 (1.18-1.89) and p=0.007, OR=1.37 (1.09-1.72), respectively)	Significant

Gene related SNPs (count: 17)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs907697	Chr1:202568735(Fwd)	intron_variant; upstream_gene_variant	1(1/0/0)
rs9633344	Chr1:202566200(Fwd)	intron_variant	1(1/0/0)
rs6427957	Chr1:202562427(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(1/0/0)
rs12739678	Chr1:202604818(Fwd)	downstream_gene_variant; intron_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs6427958	Chr1:202564330(Fwd)	3_prime_UTR_variant
rs1467120	Chr1:202569877(Fwd)	intron_variant; upstream_gene_variant
rs10494834	Chr1:202566430(Fwd)	intron_variant
rs6666325	Chr1:202567272(Fwd)	intron_variant
rs11585535	Chr1:202606051(Fwd)	downstream_gene_variant; intron_variant
rs1934663	Chr1:202608952(Fwd)	intron_variant
rs504261	Chr1:202565948(Fwd)	synonymous_variant
rs907698	Chr1:202569154(Fwd)	intron_variant; upstream_gene_variant
rs1040010	Chr1:202560412(Fwd)	3_prime_UTR_variant; downstream_gene_variant
rs4520471	Chr1:202564221(Fwd)	3_prime_UTR_variant
rs6700295	Chr1:202575620(Fwd)	downstream_gene_variant; intron_variant
rs11585137	Chr1:202606005(Fwd)	downstream_gene_variant; intron_variant
rs12354333	Chr1:202604386(Fwd)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030672	synaptic vesicle membrane	Cellular Component		15
GO:0030666	endocytic vesicle membrane	Cellular Component		11
GO:0030054	cell junction	Cellular Component		77
GO:0016021	integral to membrane	Cellular Component		845
GO:0007269	neurotransmitter secretion	Biological Process		18
GO:0007268	synaptic transmission	Biological Process		96
GO:0005886	plasma membrane	Cellular Component		772
GO:0005544	calcium-dependent phospholipid binding	Molecular Function		6
GO:0005515	protein binding	Molecular Function	IPI[19234194]	910
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005215	transporter activity	Molecular Function		41
GO:0042584	chromaffin granule membrane	Cellular Component		3
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SYT2 (count: 9)

Gene Symbol	Pathway Count	Pathway List
SYT1	12	synaptic vesicle membrane; endocytic vesicle membrane; cell junction; integral to membrane; neurotransmitter secretion; synaptic transmission; plasma membrane; calcium-dependent phospholipid binding; protein binding; calcium ion binding; transporter activity; chromaffin granule membrane;
STX1A	7	synaptic vesicle membrane; cell junction; integral to membrane; neurotransmitter secretion; synaptic transmission; plasma membrane; protein binding;
VAMP2	7	synaptic vesicle membrane; endocytic vesicle membrane; cell junction; neurotransmitter secretion; synaptic transmission; plasma membrane; protein binding;
DOC2A	6	synaptic vesicle membrane; cell junction; synaptic transmission; calcium-dependent phospholipid binding; protein binding; transporter activity;
SYT4	6	synaptic vesicle membrane; cell junction; integral to membrane; neurotransmitter secretion; calcium ion binding; transporter activity;
SYT7	6	synaptic vesicle membrane; cell junction; integral to membrane; plasma membrane; calcium ion binding; transporter activity;
DTNA	5	cell junction; synaptic transmission; plasma membrane; protein binding; calcium ion binding;
NRXN1	5	cell junction; integral to membrane; neurotransmitter secretion; plasma membrane; protein binding;
SNAP25	5	cell junction; neurotransmitter secretion; synaptic transmission; plasma membrane; protein binding;

Genes shared at least 2 KEGG pathways with SYT2 (count: 0)

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Region: chr1:202559724..202679551 View in gBrowse