ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol DBH
Symbol Alias DBM
Approved Name dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Location 9q34
Position chr9:136501482-136524466, +
External Links HGNC: 2689
Entrez Gene: 1621
Ensembl: ENSG00000123454
UCSC: uc004cel.2
No. of Studies 20 (significant: 11; non-significant: 9; trend: 0)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 20)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Payton A, 2001 there was no evidence of preferential transmission of any marker allele for the polymorphism examined in this study Non-significant
Thakur G. A., 2012 SNP rs3025343 mapped to this gene showed no significant association with ADHD in this study. Non-significant
Hawi, Z., 2012 This gene did not show significant association with ADHD. Non-significant
Wang G. X., 2012 SNP rs5320 mapped to this gene showed significant association with ADHD in this study. Significant
Brookes K, 2006 UNPHASED TDT P-value=0.0739, global P-value=0.8, WHAP TDT P_sum P-value=0.687, no SNP with nominal P-value<0.05 located in this gene Non-significant
Nyman ES, 2007 Association for an SNP in the DBH intron 12 was detected. Significant
Guan L, 2009 haplotype association analysis: Nominal P-value=0.041, Empirical P-value=0.509 for ADHD-I; Nominal P-value=0.035, Empirical P-value=0.419 for ADHD-C. 5 SNPs in this gene achieved nominal significance for ADHD-I/ADHD-C, and haplotype association test also achieved nominal significance for ADHD-I/ADHD-C. Significant
Hess C, 2009 No association was observed when comparing the DBH C-1021T full genotype distributions of adult ADHD patients and controls; howerer, a significant association was found between the rare TT genotype and ADHD. Significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Bhaduri N, 2010 haplotype 12R-TaqIG P-value=0.04, OR=2.01, X2=4.1; haplotype 12R-1021C-444G P-value=0.05, OR=1.93, X2=3.91; haplotype 12R-1021C-TaqIG P-value=0.04, OR=2.1, X2=4.41; haplotype 12R-1021C-444G-TaqIG P-value=0.04, OR=2.13, X2=4.22; revealed significant preferential transmission of haplotypes Significant
Das M, 2011 minimum UNPHASED P-value=0.0009, X2=10.9 revealed lower occurrence of T-G haplotypes in the ADHD cases; minimum ETDT P-value=0.22 showed no significant over transmission of any haplotypes Significant
Carpentier, P. J., 2012 The DBH risk genotype was associated with ADHD diagnosis, with the association strongest in the pure ADHD group. Significant
Roman T, 2002 In the present study, an association between the DBH TaqI A2 allele and ADHD was detected in a sample of Brazilian ADHD families Significant
Wigg K, 2002 TRANSMIT for haplotype transmission: smallest P=0.66. No significant evidence for biased transmission of the haplotypes and alleles were found. Non-significant
Kirley A, 2002 Significant preferential transmission of allele at DBH (allele 2, Taq I polymorphism) Significant
Hawi Z, 2003 1 marker within this gene showed significant association with ADHD; 2-marker haplotype_1.2 (DBH exon2, DBH intron5) P-value=0.045, X2=4.0143; global X2=14, 3 df, P-value=0.0029 which showed preferential transmission Significant
Smith KM, 2003 DBH TaqI A polymorphism is significantly associated with ADHD Significant
Inkster B, 2004 the results did not provide support for a role of the DBH TaqI marker in the persistent ADHD samples Non-significant
Bhaduri N, 2005 lack of significant association between transmission of 2 polymorphisms and ADHD Non-significant
Bhaduri N, 2006 (b) a haplotype comprising of allele 1 of all three polymorphisms (-1021C->T, *444g/a, TaqI RFLP) showed a minor trend towards preferential transmission from parents to probands (X2=1.65, P=0.19) Non-significant

Gene related SNPs (count: 45)

Literature-origin SNPs (count: 22)

LD-proxies (count: 23)


Gene related CNVs (count: 0)

Gene related other variant (count: 5)

Gene related regions (count: 0)

Gene related GO terms (count: 36)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 36)


Gene related KEGG pathways (count: 2)

Genes shared at least 5 GO terms with DBH (count: 9)

Genes shared at least 2 KEGG pathways with DBH (count: 10)

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Region: chr9:136501482..136524466 View in gBrowse
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Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014