ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAOB
Approved Name	monoamine oxidase B
Location	Xp11.4-p11.3
Position	chrX:43625857-43741721, -
External Links	HGNC: 6834 Entrez Gene: 4129 Ensembl: ENSG00000069535 UCSC: uc004dfz.3
No. of Studies	6 (significant: 2; non-significant: 4; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 6)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)	Haplotype analysis: P-value=0.0029, OR=1.90 for adult ADHD, specifically associated in the adult ADHD sample.	Significant
Li J, 2008	haplotype TCA P-value=0.003, X²=8.71, haplotype CTA P-value=6.978E-19, X²=78.77, haplotype TCG P-value=1.620E-6, X²=23.00, haplotype CTG P-value=6.220E-11, X²=42.75, provides the strongest evidence for the involvement of MAOB gene	Significant
Brookes K, 2006	UNPHASED TDT P-value=0.239, global P-value=0.737, no SNP with nominal P-value<0.05 located in this gene	Non-significant
Domschke K, 2005	no polymorphism was significantly associated with ADHD	Non-significant
Jiang S, 2001	the results showed that ADHD was not in linkage with MAOB gene	Non-significant
Lowe N, 2001	there was no significant association with ADHD in this study	Non-significant

Gene related SNPs (count: 43)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs3027415	ChrX:43614441(Fwd)		1(1/0/0)
rs1799836	ChrX:43627999(Fwd)	NMD_transcript_variant; intron_variant	2(1/1/0)
rs1040399	ChrX:43625399(Fwd)	downstream_gene_variant	1(1/0/0)
rs3838196	ChrX:43702604(Fwd)	downstream_gene_variant; feature_truncation; intron_variant; nc_transcript_variant	1(0/1/0)

LD-proxies (count: 39)

rs_ID	Location	Functional Annotation
rs3027449	ChrX:43649217(Fwd)	intron_variant
rs3027452	ChrX:43657789(Fwd)	intron_variant; nc_transcript_variant
rs5905512	ChrX:43726394(Fwd)	intron_variant; nc_transcript_variant
rs4824562	ChrX:43703790(Fwd)	intron_variant; nc_transcript_variant; non_coding_exon_variant
rs736944	ChrX:43675035(Fwd)	intron_variant; nc_transcript_variant
rs5952799	ChrX:43704843(Fwd)	intron_variant; nc_transcript_variant
rs3027441	ChrX:43626868(Fwd)	NMD_transcript_variant; intron_variant; splice_region_variant
rs5952671	ChrX:43626968(Fwd)	NMD_transcript_variant; intron_variant
rs2239449	ChrX:43630201(Fwd)	intron_variant; upstream_gene_variant
rs2283727	ChrX:43632944(Fwd)	intron_variant; upstream_gene_variant
rs3027435	ChrX:43624239(Fwd)	downstream_gene_variant
rs1040398	ChrX:43625431(Fwd)	downstream_gene_variant
rs3027439	ChrX:43626136(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant
rs2072745	ChrX:43626329(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant
rs5905449	ChrX:43655653(Fwd)	downstream_gene_variant; intron_variant
rs7067187	ChrX:43684216(Fwd)	intron_variant; nc_transcript_variant
rs2092041	ChrX:43647641(Fwd)	intron_variant
rs10521432	ChrX:43633740(Fwd)	intron_variant
rs2092042	ChrX:43647663(Fwd)	intron_variant
rs3027453	ChrX:43657865(Fwd)	intron_variant; nc_transcript_variant
rs3027450	ChrX:43651195(Fwd)	intron_variant
rs3027458	ChrX:43661150(Fwd)	intron_variant; nc_transcript_variant
rs3027461	ChrX:43661708(Fwd)	intron_variant; nc_transcript_variant
rs7888450	ChrX:43634003(Fwd)	intron_variant
rs1014876	ChrX:43667348(Fwd)	intron_variant; nc_transcript_variant
rs7890174	ChrX:43638952(Fwd)	intron_variant
rs3027456	ChrX:43660135(Fwd)	intron_variant; nc_transcript_variant
rs12394221	ChrX:43669949(Fwd)	intron_variant; nc_transcript_variant
rs17310637	ChrX:43639979(Fwd)	intron_variant
rs2283729	ChrX:43678042(Fwd)	intron_variant; nc_transcript_variant
rs2239450	ChrX:43683127(Fwd)	intron_variant; nc_transcript_variant
rs7892217	ChrX:43640804(Fwd)	intron_variant
rs3027440	ChrX:43626481(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant
rs3027438	ChrX:43626085(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant
rs6324	ChrX:43626815(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; synonymous_variant
rs7886240	ChrX:43621768(Fwd)	downstream_gene_variant
rs7884135	ChrX:43621409(Fwd)	downstream_gene_variant
rs12558036	ChrX:43623280(Fwd)	downstream_gene_variant
rs3027431	ChrX:43623084(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
MAOB_exon15_2276T>C	point mutation	exon 15	1 (1/0/0)
MAOB_exon15_2327T>C	point mutation	exon 15	1 (1/0/0)
MAOB_(GT)n	microsatellite		1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009636	response to toxin	Biological Process		15
GO:0009055	electron carrier activity	Molecular Function	TAS[8602220]	18
GO:0008131	primary amine oxidase activity	Molecular Function		2
GO:0006805	xenobiotic metabolic process	Biological Process		25
GO:0005743	mitochondrial inner membrane	Cellular Component		44
GO:0005741	mitochondrial outer membrane	Cellular Component		21
GO:0005740	mitochondrial envelope	Cellular Component	TAS[7063850]	3
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042493	response to drug	Biological Process		68
GO:0032496	response to lipopolysaccharide	Biological Process		22
GO:0016021	integral to membrane	Cellular Component		845
GO:0014063	negative regulation of serotonin secretion	Biological Process		1
GO:0010269	response to selenium ion	Biological Process		3
GO:0010044	response to aluminum ion	Biological Process		1
GO:0050660	flavin adenine dinucleotide binding	Molecular Function		11
GO:0051412	response to corticosterone stimulus	Biological Process		5
GO:0045471	response to ethanol	Biological Process		17
GO:0045964	positive regulation of dopamine metabolic process	Biological Process		1

Gene related KEGG pathways (count: 8)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00380	Tryptophan metabolism	12
hsa01100	Metabolic pathways	237
hsa00330	Arginine and proline metabolism	13
hsa00260	Glycine, serine and threonine metabolism	6	Serine is derived from 3-phospho-D-glycerate, an intermediat...... Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018]. More...
hsa00360	Phenylalanine metabolism	8
hsa00350	Tyrosine metabolism	15
hsa00982	Drug metabolism - cytochrome P450	29
hsa00340	Histidine metabolism	12

Genes shared at least 5 GO terms with MAOB (count: 5)

Gene Symbol	Pathway Count	Pathway List
CYP2E1	5	electron carrier activity; xenobiotic metabolic process; small molecule metabolic process; response to drug; response to ethanol;
SDHD	5	electron carrier activity; mitochondrial inner membrane; mitochondrial envelope; small molecule metabolic process; integral to membrane;
MAOA	5	primary amine oxidase activity; xenobiotic metabolic process; mitochondrial outer membrane; small molecule metabolic process; integral to membrane;
COMT	5	xenobiotic metabolic process; small molecule metabolic process; response to drug; response to lipopolysaccharide; integral to membrane;
UGT1A1	5	xenobiotic metabolic process; small molecule metabolic process; protein homodimerization activity; response to drug; response to lipopolysaccharide;

Genes shared at least 2 KEGG pathways with MAOB (count: 58)

Gene Symbol	Pathway Count	Pathway List
MAOA	8	Tryptophan metabolism; Metabolic pathways; Arginine and proline metabolism; Glycine, serine and threonine metabolism; Phenylalanine metabolism; Tyrosine metabolism; Drug metabolism - cytochrome P450; Histidine metabolism;
DDC	5	Tryptophan metabolism; Metabolic pathways; Phenylalanine metabolism; Tyrosine metabolism; Histidine metabolism;
ALDH3A1	5	Metabolic pathways; Phenylalanine metabolism; Tyrosine metabolism; Drug metabolism - cytochrome P450; Histidine metabolism;
ALDH3B1	5	Metabolic pathways; Phenylalanine metabolism; Tyrosine metabolism; Drug metabolism - cytochrome P450; Histidine metabolism;
ALDH3B2	5	Metabolic pathways; Phenylalanine metabolism; Tyrosine metabolism; Drug metabolism - cytochrome P450; Histidine metabolism;
ALDH3A2	4	Tryptophan metabolism; Metabolic pathways; Arginine and proline metabolism; Histidine metabolism;
AANAT	2	Tryptophan metabolism; Metabolic pathways;
ACAT1	2	Tryptophan metabolism; Metabolic pathways;
ASMT	2	Tryptophan metabolism; Metabolic pathways;
ECHS1	2	Tryptophan metabolism; Metabolic pathways;
HAAO	2	Tryptophan metabolism; Metabolic pathways;
TDO2	2	Tryptophan metabolism; Metabolic pathways;
TPH1	2	Tryptophan metabolism; Metabolic pathways;
TPH2	2	Tryptophan metabolism; Metabolic pathways;
AGXT2	2	Metabolic pathways; Glycine, serine and threonine metabolism;
ARG1	2	Metabolic pathways; Arginine and proline metabolism;
CKMT1A	2	Metabolic pathways; Arginine and proline metabolism;
CKMT1B	2	Metabolic pathways; Arginine and proline metabolism;
COMT	2	Metabolic pathways; Tyrosine metabolism;
CYP2E1	2	Metabolic pathways; Drug metabolism - cytochrome P450;
DBH	2	Metabolic pathways; Tyrosine metabolism;
GLUL	2	Metabolic pathways; Arginine and proline metabolism;
NOS1	2	Metabolic pathways; Arginine and proline metabolism;
ODC1	2	Metabolic pathways; Arginine and proline metabolism;
P4HA3	2	Metabolic pathways; Arginine and proline metabolism;
PNMT	2	Metabolic pathways; Tyrosine metabolism;
PRDX6	2	Metabolic pathways; Phenylalanine metabolism;
PRODH	2	Metabolic pathways; Arginine and proline metabolism;
PYCRL	2	Metabolic pathways; Arginine and proline metabolism;
SARDH	2	Metabolic pathways; Glycine, serine and threonine metabolism;
SHMT1	2	Metabolic pathways; Glycine, serine and threonine metabolism;
SHMT2	2	Metabolic pathways; Glycine, serine and threonine metabolism;
TH	2	Metabolic pathways; Tyrosine metabolism;
TYR	2	Metabolic pathways; Tyrosine metabolism;
UGT1A1	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A10	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A3	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A4	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A5	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A6	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A7	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A8	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT1A9	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2A1	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2A2	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2A3	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2B10	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2B11	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2B15	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2B17	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2B28	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2B4	2	Metabolic pathways; Drug metabolism - cytochrome P450;
UGT2B7	2	Metabolic pathways; Drug metabolism - cytochrome P450;
CARNS1	2	Arginine and proline metabolism; Histidine metabolism;
MIF	2	Phenylalanine metabolism; Tyrosine metabolism;
LCMT2	2	Tyrosine metabolism; Histidine metabolism;
TRMT11	2	Tyrosine metabolism; Histidine metabolism;
WBSCR22	2	Tyrosine metabolism; Histidine metabolism;

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Region: chrX:43625857..43741721 View in gBrowse