ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ASMT
Symbol Alias	HIOMT, ASMTY, HIOMTY
Approved Name	acetylserotonin O-methyltransferase
Location	Xp22.3 and Yp11.3
Position	chrX:1714348-1761974, +
External Links	HGNC: 750 Entrez Gene: 438 Ensembl: ENSG00000196433 UCSC: uc004cqd.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Chaste P, 2011	A splice site mutation in ASMT (IVS5+2T>C) was found and also was detected exclusively in patients with ADHD - for which biochemical analyses indicated that it abolish the activity of ASMT.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
ASMT_D210G	point mutation	1 (0/0/1)
ASMT_IVS5+2T>C	point mutation	1 (1/0/0)
ASMT_L298F	point mutation	1 (0/0/1)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042802	identical protein binding	Molecular Function		70
GO:0046219	indolalkylamine biosynthetic process	Biological Process		5
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0008171	O-methyltransferase activity	Molecular Function	TAS[8397829]	2
GO:0017096	acetylserotonin O-methyltransferase activity	Molecular Function		1
GO:0030187	melatonin biosynthetic process	Biological Process		2
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0005829	cytosol	Cellular Component		447
GO:0006412	translation	Biological Process	TAS[8397829]	42

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00380	Tryptophan metabolism	12
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with ASMT (count: 1)

Gene Symbol	Pathway Count	Pathway List
AANAT	5	indolalkylamine biosynthetic process; small molecule metabolic process; melatonin biosynthetic process; cellular nitrogen compound metabolic process; cytosol;

Genes shared at least 2 KEGG pathways with ASMT (count: 11)

Gene Symbol	Pathway Count	Pathway List
AANAT	2	Tryptophan metabolism; Metabolic pathways;
ACAT1	2	Tryptophan metabolism; Metabolic pathways;
ALDH3A2	2	Tryptophan metabolism; Metabolic pathways;
DDC	2	Tryptophan metabolism; Metabolic pathways;
ECHS1	2	Tryptophan metabolism; Metabolic pathways;
HAAO	2	Tryptophan metabolism; Metabolic pathways;
MAOA	2	Tryptophan metabolism; Metabolic pathways;
MAOB	2	Tryptophan metabolism; Metabolic pathways;
TDO2	2	Tryptophan metabolism; Metabolic pathways;
TPH1	2	Tryptophan metabolism; Metabolic pathways;
TPH2	2	Tryptophan metabolism; Metabolic pathways;

View in gBrowse

Region: chrX:1714348..1761974 View in gBrowse