ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa00380
Name Tryptophan metabolism
No. of Genes in ADHDgene  16
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 16)

Literature-origin genes (count: 8)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
TPH1 tryptophan hydroxylase 1 11p15.3-p14 6(2/4/0)
TDO2 tryptophan 2,3-dioxygenase 4q31-q32 1(1/0/0)
MAOA monoamine oxidase A Xp11.4-p11.3 20(13/7/0)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 7p12.1 6(5/1/0)
ASMT acetylserotonin O-methyltransferase Xp22.3 and Yp11.3 1(1/0/0)
AANAT aralkylamine N-acetyltransferase 17q25.1 1(0/0/1)
TPH2 tryptophan hydroxylase 2 12q15 11(8/3/0)
MAOB monoamine oxidase B Xp11.4-p11.3 6(2/4/0)

Genes from other sources Help(count: 8)

Approved Symbol Approved Name Location Source
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 6q11.1-q22.33 Mapped by significant region
ACAT1 acetyl-CoA acetyltransferase 1 11q22.3 Mapped by CNV; Mapped by significant region
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2p Mapped by LD-proxy
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 17p11.2 Mapped by significant region
WBSCR22 Williams Beuren syndrome chromosome region 22 7q11.23 Mapped by Literature SNP
LCMT2 leucine carboxyl methyltransferase 2 15q15.3 Mapped by LD-proxy
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 10q26.2-q26.3 Mapped by CNV
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 17p11.2 Mapped by significant region