ADHDgene Database

Gene Report

Basic Info

Approved Symbol	HAAO
Approved Name	3-hydroxyanthranilate 3,4-dioxygenase
Location	2p
Position	chr2:42994229-43019751, -
External Links	HGNC: 4796 Entrez Gene: 23498 Ensembl: ENSG00000162882 UCSC: uc002rst.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation
rs2278584	Chr2:42989744(Fwd)	3_prime_UTR_variant; downstream_gene_variant
rs2278582	Chr2:42989444(Fwd)	downstream_gene_variant
rs1992286	Chr2:42990336(Fwd)	downstream_gene_variant; synonymous_variant
rs965374	Chr2:42993166(Fwd)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000334	3-hydroxyanthranilate 3,4-dioxygenase activity	Molecular Function	IDA[7514594]	1
GO:0031966	mitochondrial membrane	Cellular Component		12
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046686	response to cadmium ion	Biological Process	IDA[12007609]	3
GO:0070050	neuron homeostasis	Biological Process	IMP[2967497]	1
GO:0005829	cytosol	Cellular Component	IDA[7514594]	447
GO:0006569	tryptophan catabolic process	Biological Process		2
GO:0008198	ferrous iron binding	Molecular Function	IDA[12007609]	5
GO:0009055	electron carrier activity	Molecular Function	NAS[7514594]	18
GO:0009435	NAD biosynthetic process	Biological Process		6
GO:0010043	response to zinc ion	Biological Process	IDA[12007609]	6
GO:0019805	quinolinate biosynthetic process	Biological Process	NAS[7514594]	1
GO:0019825	oxygen binding	Molecular Function		5

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00380	Tryptophan metabolism	12
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with HAAO (count: 3)

Gene Symbol	Pathway Count	Pathway List
TH	6	cellular nitrogen compound metabolic process; small molecule metabolic process; cytosol; ferrous iron binding; response to zinc ion; oxygen binding;
ARG1	5	cellular nitrogen compound metabolic process; small molecule metabolic process; response to cadmium ion; cytosol; response to zinc ion;
TDO2	5	cellular nitrogen compound metabolic process; small molecule metabolic process; cytosol; tryptophan catabolic process; oxygen binding;

Genes shared at least 2 KEGG pathways with HAAO (count: 11)

Gene Symbol	Pathway Count	Pathway List
AANAT	2	Tryptophan metabolism; Metabolic pathways;
ACAT1	2	Tryptophan metabolism; Metabolic pathways;
ALDH3A2	2	Tryptophan metabolism; Metabolic pathways;
ASMT	2	Tryptophan metabolism; Metabolic pathways;
DDC	2	Tryptophan metabolism; Metabolic pathways;
ECHS1	2	Tryptophan metabolism; Metabolic pathways;
MAOA	2	Tryptophan metabolism; Metabolic pathways;
MAOB	2	Tryptophan metabolism; Metabolic pathways;
TDO2	2	Tryptophan metabolism; Metabolic pathways;
TPH1	2	Tryptophan metabolism; Metabolic pathways;
TPH2	2	Tryptophan metabolism; Metabolic pathways;

View in gBrowse

Region: chr2:42994229..43019751 View in gBrowse