ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ALDH3A2
Previous Symbol	SLS, ALDH10
Symbol Alias	FALDH
Approved Name	aldehyde dehydrogenase 3 family, member A2
Name Alias	fatty aldehyde dehydrogenase
Location	17p11.2
Position	chr17:19551459-19580909, +
External Links	HGNC: 403 Entrez Gene: 224 Ensembl: ENSG00000072210 UCSC: uc002gwa.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005777	peroxisome	Cellular Component	IDA[17510064]	15
GO:0005743	mitochondrial inner membrane	Cellular Component		44
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Molecular Function		4
GO:0004029	aldehyde dehydrogenase (NAD) activity	Molecular Function	IDA[9133646]; IMP[15110319]	2
GO:0016021	integral to membrane	Cellular Component		845
GO:0033306	phytol metabolic process	Biological Process	IMP[15110319]	2
GO:0007422	peripheral nervous system development	Biological Process	IMP[8528251]	7
GO:0008544	epidermis development	Biological Process	IMP[8528251]	12
GO:0006714	sesquiterpenoid metabolic process	Biological Process	IDA[18035827]	1
GO:0007417	central nervous system development	Biological Process	IMP[8528251]	22
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0006081	cellular aldehyde metabolic process	Biological Process	IDA[9133646]; NAS[8528251]	3
GO:0055114	oxidation-reduction process	Biological Process	IDA[9133646]	15
GO:0050061	long-chain-aldehyde dehydrogenase activity	Molecular Function	IDA[18035827]	1
GO:0052814	medium-chain-aldehyde dehydrogenase activity	Molecular Function	IDA[18035827]	1
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	IDA[9133646]	62
GO:0046577	long-chain-alcohol oxidase activity	Molecular Function	IDA[18035827]	1

Gene related KEGG pathways (count: 14)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00380	Tryptophan metabolism	12
hsa01100	Metabolic pathways	237
hsa00330	Arginine and proline metabolism	13
hsa00561	Glycerolipid metabolism	15
hsa00620	Pyruvate metabolism	7
hsa00640	Propanoate metabolism	5
hsa00280	Valine, leucine and isoleucine degradation	7
hsa00071	Fatty acid metabolism	4
hsa00310	Lysine degradation	9
hsa00410	beta-Alanine metabolism	8
hsa00010	Glycolysis / Gluconeogenesis	11	Glycolysis is the process of converting glucose into pyruvat...... Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. More...
hsa00053	Ascorbate and aldarate metabolism	20
hsa00040	Pentose and glucuronate interconversions	21
hsa00340	Histidine metabolism	12

Genes shared at least 5 GO terms with ALDH3A2 (count: 0)

Genes shared at least 2 KEGG pathways with ALDH3A2 (count: 72)

Gene Symbol	Pathway Count	Pathway List
ACAT1	7	Tryptophan metabolism; Metabolic pathways; Pyruvate metabolism; Propanoate metabolism; Valine, leucine and isoleucine degradation; Fatty acid metabolism; Lysine degradation;
ECHS1	7	Tryptophan metabolism; Metabolic pathways; Propanoate metabolism; Valine, leucine and isoleucine degradation; Fatty acid metabolism; Lysine degradation; beta-Alanine metabolism;
MAOA	4	Tryptophan metabolism; Metabolic pathways; Arginine and proline metabolism; Histidine metabolism;
MAOB	4	Tryptophan metabolism; Metabolic pathways; Arginine and proline metabolism; Histidine metabolism;
ALDH3A1	4	Metabolic pathways; beta-Alanine metabolism; Glycolysis / Gluconeogenesis; Histidine metabolism;
ALDH3B1	4	Metabolic pathways; beta-Alanine metabolism; Glycolysis / Gluconeogenesis; Histidine metabolism;
ALDH3B2	4	Metabolic pathways; beta-Alanine metabolism; Glycolysis / Gluconeogenesis; Histidine metabolism;
DDC	3	Tryptophan metabolism; Metabolic pathways; Histidine metabolism;
ACACA	3	Metabolic pathways; Pyruvate metabolism; Propanoate metabolism;
DLAT	3	Metabolic pathways; Pyruvate metabolism; Glycolysis / Gluconeogenesis;
MLYCD	3	Metabolic pathways; Propanoate metabolism; beta-Alanine metabolism;
UGT1A1	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A10	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A3	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A4	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A5	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A6	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A7	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A8	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT1A9	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2A1	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2A2	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2A3	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2B10	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2B11	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2B15	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2B17	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2B28	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2B4	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
UGT2B7	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
CARNS1	3	Arginine and proline metabolism; beta-Alanine metabolism; Histidine metabolism;
AANAT	2	Tryptophan metabolism; Metabolic pathways;
ASMT	2	Tryptophan metabolism; Metabolic pathways;
HAAO	2	Tryptophan metabolism; Metabolic pathways;
TDO2	2	Tryptophan metabolism; Metabolic pathways;
TPH1	2	Tryptophan metabolism; Metabolic pathways;
TPH2	2	Tryptophan metabolism; Metabolic pathways;
ACAD8	2	Metabolic pathways; Valine, leucine and isoleucine degradation;
ALDOA	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDOB	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ARG1	2	Metabolic pathways; Arginine and proline metabolism;
AUH	2	Metabolic pathways; Valine, leucine and isoleucine degradation;
CKMT1A	2	Metabolic pathways; Arginine and proline metabolism;
CKMT1B	2	Metabolic pathways; Arginine and proline metabolism;
CRYL1	2	Metabolic pathways; Pentose and glucuronate interconversions;
DAK	2	Metabolic pathways; Glycerolipid metabolism;
DGAT2	2	Metabolic pathways; Glycerolipid metabolism;
DGKH	2	Metabolic pathways; Glycerolipid metabolism;
FBP1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
FBP2	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
GLUL	2	Metabolic pathways; Arginine and proline metabolism;
GPAT2	2	Metabolic pathways; Glycerolipid metabolism;
HIBADH	2	Metabolic pathways; Valine, leucine and isoleucine degradation;
HK1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
HKDC1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
LIPF	2	Metabolic pathways; Glycerolipid metabolism;
LIPG	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerolipid metabolism;
ME3	2	Metabolic pathways; Pyruvate metabolism;
MGLL	2	Metabolic pathways; Glycerolipid metabolism;
NOS1	2	Metabolic pathways; Arginine and proline metabolism;
ODC1	2	Metabolic pathways; Arginine and proline metabolism;
P4HA3	2	Metabolic pathways; Arginine and proline metabolism;
PC	2	Metabolic pathways; Pyruvate metabolism;
PNLIP	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP1	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP2	2	Metabolic pathways; Glycerolipid metabolism;
PNPLA3	2	Metabolic pathways; Glycerolipid metabolism;
PRODH	2	Metabolic pathways; Arginine and proline metabolism;
PYCRL	2	Metabolic pathways; Arginine and proline metabolism;
UPB1	2	Metabolic pathways; beta-Alanine metabolism;

View in gBrowse

Region: chr17:19551459..19580909 View in gBrowse