ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ME3
Approved Name	malic enzyme 3, NADP(+)-dependent, mitochondrial
Location	11
Position	chr11:86152150-86383678, -
External Links	HGNC: 6985 Entrez Gene: 10873 Ensembl: ENSG00000151376 UCSC: uc001pbz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006108	malate metabolic process	Biological Process	IDA[7818469]	1
GO:0006090	pyruvate metabolic process	Biological Process	IDA[7818469]	3
GO:0016619	malate dehydrogenase (oxaloacetate-decarboxylating) activity	Molecular Function		1
GO:0009060	aerobic respiration	Biological Process	TAS[7818469]	2
GO:0004473	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity	Molecular Function	IDA[7818469]	1
GO:0004470	malic enzyme activity	Molecular Function	IDA[7818469]	1
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0005739	mitochondrion	Cellular Component	TAS[7818469]	183
GO:0055114	oxidation-reduction process	Biological Process	IDA[7818469]	15
GO:0051287	NAD binding	Molecular Function		4
GO:0048037	cofactor binding	Molecular Function	TAS[7818469]	2
GO:0046872	metal ion binding	Molecular Function		170
GO:0072592	oxygen metabolic process	Biological Process	TAS[7818469]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00620	Pyruvate metabolism	7

Genes shared at least 5 GO terms with ME3 (count: 0)

Genes shared at least 2 KEGG pathways with ME3 (count: 5)

Gene Symbol	Pathway Count	Pathway List
ACACA	2	Metabolic pathways; Pyruvate metabolism;
ACAT1	2	Metabolic pathways; Pyruvate metabolism;
ALDH3A2	2	Metabolic pathways; Pyruvate metabolism;
DLAT	2	Metabolic pathways; Pyruvate metabolism;
PC	2	Metabolic pathways; Pyruvate metabolism;

View in gBrowse

Region: chr11:86152150..86383678 View in gBrowse