ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	UPB1
Symbol Alias	BUP1
Approved Name	ureidopropionase, beta
Location	22q11.2
Position	chr22:24890075-24924358, +
External Links	HGNC: 16297 Entrez Gene: 51733 Ensembl: ENSG00000100024 UCSC: uc003aaf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_37	chr22:22020325-23326630 (NCBI Build 36.1 (hg18))	1306306	22q11.23	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 8)

ID	Name	Type	No. of Genes in ADHDgene
GO:0003837	beta-ureidopropionase activity	Molecular Function	1
GO:0005829	cytosol	Cellular Component	447
GO:0006206	pyrimidine nucleobase metabolic process	Biological Process	3
GO:0019483	beta-alanine biosynthetic process	Biological Process	1
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0046135	pyrimidine nucleoside catabolic process	Biological Process	3
GO:0046872	metal ion binding	Molecular Function	170
GO:0055086	nucleobase-containing small molecule metabolic process	Biological Process	9

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00770	Pantothenate and CoA biosynthesis	7
hsa00983	Drug metabolism - other enzymes	25
hsa00240	Pyrimidine metabolism	13
hsa00410	beta-Alanine metabolism	8

Genes shared at least 5 GO terms with UPB1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
NT5M	5	pyrimidine nucleobase metabolic process; small molecule metabolic process; pyrimidine nucleoside catabolic process; metal ion binding; nucleobase-containing small molecule metabolic process;

Genes shared at least 2 KEGG pathways with UPB1 (count: 41)

Gene Symbol	Pathway Count	Pathway List
ITPA	3	Metabolic pathways; Drug metabolism - other enzymes; Pyrimidine metabolism;
ALDH3A1	2	Metabolic pathways; beta-Alanine metabolism;
ALDH3A2	2	Metabolic pathways; beta-Alanine metabolism;
ALDH3B1	2	Metabolic pathways; beta-Alanine metabolism;
ALDH3B2	2	Metabolic pathways; beta-Alanine metabolism;
CES1	2	Metabolic pathways; Drug metabolism - other enzymes;
CES5A	2	Metabolic pathways; Drug metabolism - other enzymes;
ECHS1	2	Metabolic pathways; beta-Alanine metabolism;
ENPP1	2	Metabolic pathways; Pantothenate and CoA biosynthesis;
ENPP3	2	Metabolic pathways; Pantothenate and CoA biosynthesis;
MLYCD	2	Metabolic pathways; beta-Alanine metabolism;
NAT2	2	Metabolic pathways; Drug metabolism - other enzymes;
NT5M	2	Metabolic pathways; Pyrimidine metabolism;
PANK2	2	Metabolic pathways; Pantothenate and CoA biosynthesis;
POLA2	2	Metabolic pathways; Pyrimidine metabolism;
POLD3	2	Metabolic pathways; Pyrimidine metabolism;
POLD4	2	Metabolic pathways; Pyrimidine metabolism;
POLE	2	Metabolic pathways; Pyrimidine metabolism;
POLE3	2	Metabolic pathways; Pyrimidine metabolism;
POLR1A	2	Metabolic pathways; Pyrimidine metabolism;
POLR2G	2	Metabolic pathways; Pyrimidine metabolism;
RRM2	2	Metabolic pathways; Pyrimidine metabolism;
UGT1A1	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A10	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A3	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A4	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A5	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A6	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A7	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A8	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT1A9	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2A1	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2A2	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2A3	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2B10	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2B11	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2B15	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2B17	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2B28	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2B4	2	Metabolic pathways; Drug metabolism - other enzymes;
UGT2B7	2	Metabolic pathways; Drug metabolism - other enzymes;

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Region: chr22:24890075..24924358 View in gBrowse