ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MBOAT1
Previous Symbol	OACT1
Symbol Alias	MGC44669, dJ434O11.1, LPEAT1
Approved Name	membrane bound O-acyltransferase domain containing 1
Previous Name	O-acyltransferase (membrane bound) domain containing 1
Name Alias	lysophosphatidylethanolamine acyltransferase 1
Location	6p22.3
Position	chr6:20100935-20212670, -
External Links	HGNC: 21579 Entrez Gene: 154141 Ensembl: ENSG00000172197 UCSC: uc003ncx.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 7)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1202199	Chr6:20156174(Fwd)	intron_variant	1(0/0/1)

LD-proxies (count: 6)

rs_ID	Location	Functional Annotation
rs1202198	Chr6:20145879(Fwd)	intron_variant
rs1212547	Chr6:20146507(Fwd)	intron_variant
rs2472756	Chr6:20120469(Fwd)	intron_variant
rs2839922	Chr6:20134819(Fwd)	intron_variant
rs10484637	Chr6:20123817(Fwd)	downstream_gene_variant; intron_variant
rs843327	Chr6:20145314(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 8)

ID	Name	Type	No. of Genes in ADHDgene
GO:0046474	glycerophospholipid biosynthetic process	Biological Process	30
GO:0006644	phospholipid metabolic process	Biological Process	59
GO:0016021	integral to membrane	Cellular Component	845
GO:0005789	endoplasmic reticulum membrane	Cellular Component	140
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	Biological Process	15
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Molecular Function	2
GO:0036150	phosphatidylserine acyl-chain remodeling	Biological Process	10

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00561	Glycerolipid metabolism	15
hsa00564	Glycerophospholipid metabolism	22

Genes shared at least 5 GO terms with MBOAT1 (count: 18)

Gene Symbol	Pathway Count	Pathway List
LPCAT4	7	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
MBOAT2	6	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process;
PLA2G16	6	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PLA2G2A	6	glycerophospholipid biosynthetic process; phospholipid metabolic process; endoplasmic reticulum membrane; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PNPLA8	6	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process;
CDIPT	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; small molecule metabolic process;
DGAT2	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; small molecule metabolic process;
LPCAT1	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; small molecule metabolic process;
PEMT	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; small molecule metabolic process;
PLA2G10	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PLA2G1B	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PLA2G2D	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PLA2G2E	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PLA2G4B	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PLA2G4C	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; endoplasmic reticulum membrane; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process;
PLA2G5	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PLD3	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; small molecule metabolic process;
PNPLA3	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with MBOAT1 (count: 29)

Gene Symbol	Pathway Count	Pathway List
DGKH	3	Metabolic pathways; Glycerolipid metabolism; Glycerophospholipid metabolism;
GPAT2	3	Metabolic pathways; Glycerolipid metabolism; Glycerophospholipid metabolism;
MBOAT2	3	Metabolic pathways; Glycerolipid metabolism; Glycerophospholipid metabolism;
ALDH3A2	2	Metabolic pathways; Glycerolipid metabolism;
CDIPT	2	Metabolic pathways; Glycerophospholipid metabolism;
CHKA	2	Metabolic pathways; Glycerophospholipid metabolism;
DAK	2	Metabolic pathways; Glycerolipid metabolism;
DGAT2	2	Metabolic pathways; Glycerolipid metabolism;
LIPF	2	Metabolic pathways; Glycerolipid metabolism;
LIPG	2	Metabolic pathways; Glycerolipid metabolism;
LPCAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
LPCAT4	2	Metabolic pathways; Glycerophospholipid metabolism;
MGLL	2	Metabolic pathways; Glycerolipid metabolism;
PEMT	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G10	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G1B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2A	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2D	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2E	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G3	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G4B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G5	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G6	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD1	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD2	2	Metabolic pathways; Glycerophospholipid metabolism;
PNLIP	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP1	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP2	2	Metabolic pathways; Glycerolipid metabolism;
PNPLA3	2	Metabolic pathways; Glycerolipid metabolism;

View in gBrowse

Region: chr6:20100935..20212670 View in gBrowse