ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PLD3
Symbol Alias	HU-K4
Approved Name	phospholipase D family, member 3
Previous Name	phospholipase D3
Location	19q13.2
Position	chr19:40854332-40886346, +
External Links	HGNC: 17158 Entrez Gene: 23646 Ensembl: ENSG00000105223 UCSC: uc002onj.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 10)

ID	Name	Type	No. of Genes in ADHDgene
GO:0070290	NAPE-specific phospholipase D activity	Molecular Function	3
GO:0005515	protein binding	Molecular Function	910
GO:0004630	phospholipase D activity	Molecular Function	3
GO:0005789	endoplasmic reticulum membrane	Cellular Component	140
GO:0006644	phospholipid metabolic process	Biological Process	59
GO:0006655	phosphatidylglycerol biosynthetic process	Biological Process	4
GO:0016021	integral to membrane	Cellular Component	845
GO:0016042	lipid catabolic process	Biological Process	32
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0046474	glycerophospholipid biosynthetic process	Biological Process	30

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PLD3 (count: 24)

Gene Symbol	Pathway Count	Pathway List
PLD2	10	NAPE-specific phospholipase D activity; protein binding; phospholipase D activity; endoplasmic reticulum membrane; phospholipid metabolic process; phosphatidylglycerol biosynthetic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLD1	9	NAPE-specific phospholipase D activity; phospholipase D activity; endoplasmic reticulum membrane; phospholipid metabolic process; phosphatidylglycerol biosynthetic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G16	6	protein binding; phospholipid metabolic process; integral to membrane; lipid catabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G2A	6	endoplasmic reticulum membrane; phospholipid metabolic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PNPLA3	6	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PNPLA8	6	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLD6	6	phospholipid metabolic process; phosphatidylglycerol biosynthetic process; integral to membrane; lipid catabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process;
SPTLC1	5	protein binding; endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process;
CDIPT	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
DGAT2	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
LPCAT1	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
LPCAT4	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
MBOAT1	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
MBOAT2	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
MGLL	5	endoplasmic reticulum membrane; phospholipid metabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PEMT	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G4C	5	endoplasmic reticulum membrane; phospholipid metabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
SMPD4	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; lipase activity; small molecule metabolic process;
PLA2G10	5	phospholipid metabolic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G2D	5	phospholipid metabolic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G2E	5	phospholipid metabolic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G3	5	phospholipid metabolic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G5	5	phospholipid metabolic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLA2G6	5	phospholipid metabolic process; lipid catabolic process; lipase activity; small molecule metabolic process; glycerophospholipid biosynthetic process;

Genes shared at least 2 KEGG pathways with PLD3 (count: 0)

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Region: chr19:40854332..40886346 View in gBrowse