ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SMPD4
Symbol Alias	FLJ20297, FLJ20756, nSMase-3, KIAA1418, NSMASE3, NET13
Approved Name	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Location	2q21.1
Position	chr2:130908965-130940323, -
External Links	HGNC: 32949 Entrez Gene: 55627 Ensembl: ENSG00000136699 UCSC: uc002tqq.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q21.1	chr2:129900000-132500000	1 (1/0/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046513	ceramide biosynthetic process	Biological Process	IDA[16517606]	3
GO:0046475	glycerophospholipid catabolic process	Biological Process	IDA[16517606]	3
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0071356	cellular response to tumor necrosis factor	Biological Process	IDA[16517606]	9
GO:0050290	sphingomyelin phosphodiesterase D activity	Molecular Function	IDA[16517606]	1
GO:0046872	metal ion binding	Molecular Function		170
GO:0006665	sphingolipid metabolic process	Biological Process		16
GO:0006685	sphingomyelin catabolic process	Biological Process	IDA[16517606]	3
GO:0006687	glycosphingolipid metabolic process	Biological Process		9
GO:0016021	integral to membrane	Cellular Component		845
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005794	Golgi apparatus	Cellular Component	IDA[16517606]	157
GO:0005802	trans-Golgi network	Cellular Component	IDA[16517606]	28
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0000139	Golgi membrane	Cellular Component		95
GO:0004767	sphingomyelin phosphodiesterase activity	Molecular Function		5
GO:0005783	endoplasmic reticulum	Cellular Component	IDA[18505924]	100

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00600	Sphingolipid metabolism	10
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with SMPD4 (count: 22)

Gene Symbol	Pathway Count	Pathway List
STS	9	small molecule metabolic process; metal ion binding; sphingolipid metabolic process; glycosphingolipid metabolic process; integral to membrane; endoplasmic reticulum membrane; Golgi apparatus; phospholipid metabolic process; endoplasmic reticulum;
SMPD1	8	ceramide biosynthetic process; small molecule metabolic process; lipase activity; sphingolipid metabolic process; sphingomyelin catabolic process; glycosphingolipid metabolic process; phospholipid metabolic process; sphingomyelin phosphodiesterase activity;
SMPD2	8	ceramide biosynthetic process; small molecule metabolic process; lipase activity; metal ion binding; sphingolipid metabolic process; glycosphingolipid metabolic process; phospholipid metabolic process; sphingomyelin phosphodiesterase activity;
ENPP7	8	small molecule metabolic process; lipase activity; sphingolipid metabolic process; glycosphingolipid metabolic process; integral to membrane; Golgi apparatus; phospholipid metabolic process; sphingomyelin phosphodiesterase activity;
LPCAT1	7	small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; Golgi apparatus; phospholipid metabolic process; Golgi membrane; endoplasmic reticulum;
PLD1	6	small molecule metabolic process; lipase activity; endoplasmic reticulum membrane; Golgi apparatus; phospholipid metabolic process; Golgi membrane;
PNPLA8	6	small molecule metabolic process; lipase activity; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process; Golgi membrane;
PRKD1	6	small molecule metabolic process; metal ion binding; sphingolipid metabolic process; Golgi apparatus; trans-Golgi network; phospholipid metabolic process;
UGCG	6	small molecule metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; integral to membrane; phospholipid metabolic process; Golgi membrane;
PLA2G4C	5	glycerophospholipid catabolic process; small molecule metabolic process; lipase activity; endoplasmic reticulum membrane; phospholipid metabolic process;
ARSJ	5	small molecule metabolic process; metal ion binding; sphingolipid metabolic process; glycosphingolipid metabolic process; phospholipid metabolic process;
CDIPT	5	small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process; Golgi membrane;
DGAT2	5	small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process; endoplasmic reticulum;
DSE	5	small molecule metabolic process; integral to membrane; Golgi apparatus; Golgi membrane; endoplasmic reticulum;
PLA2G2A	5	small molecule metabolic process; lipase activity; endoplasmic reticulum membrane; phospholipid metabolic process; endoplasmic reticulum;
PLD3	5	small molecule metabolic process; lipase activity; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
PNPLA3	5	small molecule metabolic process; lipase activity; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
SPTLC1	5	small molecule metabolic process; sphingolipid metabolic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
SPTLC3	5	small molecule metabolic process; sphingolipid metabolic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
SUMF1	5	small molecule metabolic process; metal ion binding; sphingolipid metabolic process; glycosphingolipid metabolic process; phospholipid metabolic process;
TPTE2	5	small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process; Golgi membrane;
LMAN2L	5	metal ion binding; integral to membrane; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane;

Genes shared at least 2 KEGG pathways with SMPD4 (count: 7)

Gene Symbol	Pathway Count	Pathway List
B4GALT6	2	Sphingolipid metabolism; Metabolic pathways;
ENPP7	2	Sphingolipid metabolism; Metabolic pathways;
SMPD1	2	Sphingolipid metabolism; Metabolic pathways;
SMPD2	2	Sphingolipid metabolism; Metabolic pathways;
SPTLC1	2	Sphingolipid metabolism; Metabolic pathways;
SPTLC3	2	Sphingolipid metabolism; Metabolic pathways;
UGCG	2	Sphingolipid metabolism; Metabolic pathways;

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Region: chr2:130908965..130940323 View in gBrowse