ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ENPP7
Symbol Alias	alk-SMase
Approved Name	ectonucleotide pyrophosphatase/phosphodiesterase 7
Location	17q25.3
Position	chr17:77704681-77716021, +
External Links	HGNC: 23764 Entrez Gene: 339221 Ensembl: ENSG00000182156 UCSC: uc002jxa.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005902	microvillus	Cellular Component	IDA[12671034]	8
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0005794	Golgi apparatus	Cellular Component	IDA[12671034]	157
GO:0005886	plasma membrane	Cellular Component		772
GO:0004767	sphingomyelin phosphodiesterase activity	Molecular Function	IDA[12671034]	5
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0016021	integral to membrane	Cellular Component		845
GO:0016020	membrane	Cellular Component	NAS[12885774]	139
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA[12671034]	59
GO:0008156	negative regulation of DNA replication	Biological Process	IDA[12671034]	3
GO:0006687	glycosphingolipid metabolic process	Biological Process		9
GO:0006684	sphingomyelin metabolic process	Biological Process	IDA[12671034]	3
GO:0006665	sphingolipid metabolic process	Biological Process		16

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00600	Sphingolipid metabolism	10
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with ENPP7 (count: 13)

Gene Symbol	Pathway Count	Pathway List
SMPD2	8	phospholipid metabolic process; plasma membrane; sphingomyelin phosphodiesterase activity; small molecule metabolic process; lipase activity; glycosphingolipid metabolic process; sphingomyelin metabolic process; sphingolipid metabolic process;
SMPD4	8	phospholipid metabolic process; Golgi apparatus; sphingomyelin phosphodiesterase activity; small molecule metabolic process; lipase activity; integral to membrane; glycosphingolipid metabolic process; sphingolipid metabolic process;
STS	8	phospholipid metabolic process; Golgi apparatus; plasma membrane; small molecule metabolic process; integral to membrane; membrane; glycosphingolipid metabolic process; sphingolipid metabolic process;
SMPD1	7	phospholipid metabolic process; sphingomyelin phosphodiesterase activity; small molecule metabolic process; lipase activity; glycosphingolipid metabolic process; sphingomyelin metabolic process; sphingolipid metabolic process;
INPPL1	6	phospholipid metabolic process; Golgi apparatus; plasma membrane; small molecule metabolic process; negative regulation of cell proliferation; negative regulation of DNA replication;
UGCG	6	phospholipid metabolic process; small molecule metabolic process; integral to membrane; membrane; glycosphingolipid metabolic process; sphingolipid metabolic process;
ACHE	5	phospholipid metabolic process; Golgi apparatus; plasma membrane; small molecule metabolic process; membrane;
NEU3	5	phospholipid metabolic process; plasma membrane; small molecule metabolic process; glycosphingolipid metabolic process; sphingolipid metabolic process;
PLA2G5	5	phospholipid metabolic process; Golgi apparatus; plasma membrane; small molecule metabolic process; lipase activity;
PLD1	5	phospholipid metabolic process; Golgi apparatus; small molecule metabolic process; lipase activity; membrane;
PNPLA3	5	phospholipid metabolic process; small molecule metabolic process; lipase activity; integral to membrane; membrane;
PNPLA8	5	phospholipid metabolic process; small molecule metabolic process; lipase activity; integral to membrane; membrane;
PRKD1	5	phospholipid metabolic process; Golgi apparatus; plasma membrane; small molecule metabolic process; sphingolipid metabolic process;

Genes shared at least 2 KEGG pathways with ENPP7 (count: 7)

Gene Symbol	Pathway Count	Pathway List
B4GALT6	2	Sphingolipid metabolism; Metabolic pathways;
SMPD1	2	Sphingolipid metabolism; Metabolic pathways;
SMPD2	2	Sphingolipid metabolism; Metabolic pathways;
SMPD4	2	Sphingolipid metabolism; Metabolic pathways;
SPTLC1	2	Sphingolipid metabolism; Metabolic pathways;
SPTLC3	2	Sphingolipid metabolism; Metabolic pathways;
UGCG	2	Sphingolipid metabolism; Metabolic pathways;

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Region: chr17:77704681..77716021 View in gBrowse