ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SPTLC1
Previous Symbol	HSN1
Symbol Alias	LCB1, SPTI, HSAN1
Approved Name	serine palmitoyltransferase, long chain base subunit 1
Previous Name	hereditary sensory neuropathy, type 1
Location	9q22.31
Position	chr9:94793427-94877690, -
External Links	HGNC: 11277 Entrez Gene: 10558 Ensembl: ENSG00000090054 UCSC: uc004arl.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046511	sphinganine biosynthetic process	Biological Process		1
GO:0046512	sphingosine biosynthetic process	Biological Process		2
GO:0017059	serine C-palmitoyltransferase complex	Cellular Component	IDA[19416851]	2
GO:0030148	sphingolipid biosynthetic process	Biological Process		4
GO:0030170	pyridoxal phosphate binding	Molecular Function		12
GO:0035339	SPOTS complex	Cellular Component		1
GO:0006665	sphingolipid metabolic process	Biological Process		16
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0016021	integral to membrane	Cellular Component		845
GO:0006686	sphingomyelin biosynthetic process	Biological Process		1
GO:0004758	serine C-palmitoyltransferase activity	Molecular Function	IDA[19416851]	2
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005515	protein binding	Molecular Function		910

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00600	Sphingolipid metabolism	10
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with SPTLC1 (count: 6)

Gene Symbol	Pathway Count	Pathway List
SPTLC3	9	small molecule metabolic process; serine C-palmitoyltransferase complex; sphingolipid biosynthetic process; pyridoxal phosphate binding; sphingolipid metabolic process; phospholipid metabolic process; integral to membrane; serine C-palmitoyltransferase activity; endoplasmic reticulum membrane;
ACER3	6	small molecule metabolic process; sphingosine biosynthetic process; sphingolipid biosynthetic process; sphingolipid metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
PLD3	5	small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; protein binding;
PRKD1	5	small molecule metabolic process; sphingolipid biosynthetic process; sphingolipid metabolic process; phospholipid metabolic process; protein binding;
SMPD4	5	small molecule metabolic process; sphingolipid metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
STS	5	small molecule metabolic process; sphingolipid metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;

Genes shared at least 2 KEGG pathways with SPTLC1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
B4GALT6	2	Sphingolipid metabolism; Metabolic pathways;
ENPP7	2	Sphingolipid metabolism; Metabolic pathways;
SMPD1	2	Sphingolipid metabolism; Metabolic pathways;
SMPD2	2	Sphingolipid metabolism; Metabolic pathways;
SMPD4	2	Sphingolipid metabolism; Metabolic pathways;
SPTLC3	2	Sphingolipid metabolism; Metabolic pathways;
UGCG	2	Sphingolipid metabolism; Metabolic pathways;

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Region: chr9:94793427..94877690 View in gBrowse