ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	INPPL1
Symbol Alias	SHIP2
Approved Name	inositol polyphosphate phosphatase-like 1
Name Alias	"51C protein"
Location	11q23
Position	chr11:71934745-71950149, 1
External Links	HGNC: 6080 Entrez Gene: 3636 Ensembl: ENSG00000165458 UCSC: uc001osf.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032957	inositol trisphosphate metabolic process	biological process	IEA	1
GO:0009791	post-embryonic development	biological process	IEA	17
GO:0008156	negative regulation of DNA replication	biological process	IEA	3
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	13
GO:0042169	SH2 domain binding	molecular function	IPI[5668240]	8
GO:0006006	glucose metabolic process	biological process	IEA	20
GO:0030027	lamellipodium	cellular component	IEA	29
GO:0042493	response to drug	biological process	IEA	73
GO:0007420	brain development	biological process	IEA	36
GO:0010977	negative regulation of neuron projection development	biological process	IEA	4
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	biological process	IEA	3
GO:0046627	negative regulation of insulin receptor signaling pathway	biological process	IEA	5
GO:0010629	negative regulation of gene expression	biological process	IEA	13
GO:0007155	cell adhesion	biological process	TAS[15668240]	99
GO:0007015	actin filament organization	biological process	IMP[15668240]	12
GO:0005886	plasma membrane	cellular component	IEA	839
GO:0005794	Golgi apparatus	cellular component	IDA	174
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA	5
GO:0004445	inositol-polyphosphate 5-phosphatase activity	molecular function	IEA	2
GO:0008285	negative regulation of cell proliferation	biological process	IEA	65
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	molecular function	IEA	4
GO:0043407	negative regulation of MAP kinase activity	biological process	IEA	8
GO:0005829	cytosol	cellular component	TAS	485
GO:0017124	SH3 domain binding	molecular function	IEA	22
GO:0097178	ruffle assembly	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI	1015
GO:0006897	endocytosis	biological process	IMP[15668240]	26
GO:0032868	response to insulin stimulus	biological process	IEA	11
GO:0003779	actin binding	molecular function	IEA	48
GO:0030479	actin cortical patch	cellular component	IEA	1
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	biological process	IEA	3
GO:0006644	phospholipid metabolic process	biological process	TAS	61

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00562	Inositol phosphate metabolism	12
hsa04070	Phosphatidylinositol signaling system	19

Genes shared at least 5 GO terms with INPPL1 (count: 59)

Gene Symbol	Pathway Count	Pathway List
PIK3CG	8	phosphatidylinositol biosynthetic process; cytoplasm; small molecule metabolic process; plasma membrane; cytosol; protein binding; endocytosis; phospholipid metabolic process;
SNCA	8	response to drug; cytoplasm; plasma membrane; Golgi apparatus; cytosol; protein binding; negative regulation of platelet-derived growth factor receptor signaling pathway; phospholipid metabolic process;
PIK3R1	7	phosphatidylinositol biosynthetic process; small molecule metabolic process; plasma membrane; phosphatidylinositol phosphorylation; cytosol; protein binding; phospholipid metabolic process;
CRYAB	7	glucose metabolic process; cytoplasm; negative regulation of gene expression; plasma membrane; Golgi apparatus; cytosol; protein binding;
APC	7	lamellipodium; cytoplasm; cell adhesion; plasma membrane; negative regulation of cell proliferation; cytosol; protein binding;
PRKD1	7	cytoplasm; small molecule metabolic process; plasma membrane; Golgi apparatus; cytosol; protein binding; phospholipid metabolic process;
TSC2	7	cytoplasm; Golgi apparatus; negative regulation of cell proliferation; negative regulation of MAP kinase activity; cytosol; protein binding; endocytosis;
BCAR1	7	cytoplasm; cell adhesion; actin filament organization; plasma membrane; cytosol; SH3 domain binding; protein binding;
NF2	6	negative regulation of DNA replication; lamellipodium; cytoplasm; plasma membrane; negative regulation of cell proliferation; protein binding;
ENPP7	6	negative regulation of DNA replication; small molecule metabolic process; plasma membrane; Golgi apparatus; negative regulation of cell proliferation; phospholipid metabolic process;
MTMR2	6	phosphatidylinositol biosynthetic process; cytoplasm; small molecule metabolic process; cytosol; protein binding; phospholipid metabolic process;
TSC1	6	lamellipodium; cytoplasm; negative regulation of cell proliferation; cytosol; protein binding; response to insulin stimulus;
ILK	6	lamellipodium; cytoplasm; plasma membrane; cytosol; SH3 domain binding; protein binding;
CTNND1	6	lamellipodium; cytoplasm; cell adhesion; plasma membrane; cytosol; protein binding;
WASL	6	lamellipodium; small molecule metabolic process; plasma membrane; cytosol; protein binding; actin binding;
ADAM17	6	response to drug; cytoplasm; cell adhesion; plasma membrane; SH3 domain binding; protein binding;
HMGCS1	6	response to drug; brain development; cytoplasm; small molecule metabolic process; plasma membrane; cytosol;
RELA	6	response to drug; cytoplasm; negative regulation of insulin receptor signaling pathway; cytosol; protein binding; response to insulin stimulus;
GSK3B	6	response to drug; cytoplasm; plasma membrane; negative regulation of MAP kinase activity; cytosol; protein binding;
GRB10	6	cytoplasm; negative regulation of insulin receptor signaling pathway; plasma membrane; cytosol; protein binding; response to insulin stimulus;
ACHE	6	small molecule metabolic process; cell adhesion; plasma membrane; Golgi apparatus; protein binding; phospholipid metabolic process;
PIK3C3	5	phosphatidylinositol biosynthetic process; small molecule metabolic process; cytosol; protein binding; phospholipid metabolic process;
PI4KA	5	phosphatidylinositol biosynthetic process; small molecule metabolic process; cytosol; protein binding; phospholipid metabolic process;
PI4K2B	5	phosphatidylinositol biosynthetic process; cytoplasm; small molecule metabolic process; cytosol; phospholipid metabolic process;
NUP62	5	SH2 domain binding; cytoplasm; small molecule metabolic process; negative regulation of cell proliferation; protein binding;
ALDOA	5	glucose metabolic process; small molecule metabolic process; actin filament organization; cytosol; actin binding;
FBP1	5	glucose metabolic process; cytoplasm; small molecule metabolic process; cytosol; protein binding;
CCDC88A	5	lamellipodium; plasma membrane; Golgi apparatus; cytosol; actin binding;
CORO1A	5	lamellipodium; cytoplasm; actin filament organization; plasma membrane; protein binding;
RDX	5	lamellipodium; cytoplasm; plasma membrane; protein binding; actin binding;
MYO10	5	lamellipodium; cytoplasm; plasma membrane; phosphatidylinositol-3,4,5-trisphosphate binding; cytosol;
LPL	5	response to drug; small molecule metabolic process; plasma membrane; protein binding; phospholipid metabolic process;
TJP1	5	response to drug; cytoplasm; plasma membrane; cytosol; protein binding;
ARRB2	5	brain development; cytoplasm; plasma membrane; cytosol; protein binding;
CDK5RAP2	5	brain development; cytoplasm; Golgi apparatus; cytosol; protein binding;
MEN1	5	brain development; cytoplasm; negative regulation of cell proliferation; cytosol; protein binding;
STAB2	5	cytoplasm; small molecule metabolic process; cell adhesion; plasma membrane; endocytosis;
STK11	5	cytoplasm; small molecule metabolic process; negative regulation of cell proliferation; cytosol; protein binding;
CBL	5	cytoplasm; plasma membrane; cytosol; SH3 domain binding; protein binding;
PAK1	5	cytoplasm; plasma membrane; Golgi apparatus; cytosol; protein binding;
PRKG1	5	cytoplasm; plasma membrane; Golgi apparatus; cytosol; protein binding;
ARPC2	5	cytoplasm; plasma membrane; Golgi apparatus; protein binding; actin binding;
GSTP1	5	cytoplasm; small molecule metabolic process; negative regulation of MAP kinase activity; cytosol; protein binding;
CLASP2	5	cytoplasm; plasma membrane; Golgi apparatus; cytosol; protein binding;
NCK1	5	cytoplasm; actin filament organization; plasma membrane; cytosol; protein binding;
NCK2	5	cytoplasm; actin filament organization; negative regulation of cell proliferation; cytosol; protein binding;
BAIAP2	5	cytoplasm; plasma membrane; cytosol; SH3 domain binding; protein binding;
WWOX	5	cytoplasm; plasma membrane; Golgi apparatus; cytosol; protein binding;
PLCE1	5	cytoplasm; plasma membrane; cytosol; protein binding; phospholipid metabolic process;
GAB2	5	cytoplasm; plasma membrane; phosphatidylinositol-3,4,5-trisphosphate binding; cytosol; protein binding;
PDE2A	5	cytoplasm; plasma membrane; Golgi apparatus; cytosol; protein binding;
FABP6	5	cytoplasm; small molecule metabolic process; Golgi apparatus; negative regulation of cell proliferation; cytosol;
FLNC	5	cytoplasm; plasma membrane; cytosol; protein binding; actin binding;
SORT1	5	cytoplasm; plasma membrane; Golgi apparatus; endocytosis; response to insulin stimulus;
CTGF	5	small molecule metabolic process; negative regulation of gene expression; plasma membrane; Golgi apparatus; cytosol;
CAV3	5	actin filament organization; plasma membrane; negative regulation of MAP kinase activity; protein binding; endocytosis;
PTPRJ	5	plasma membrane; negative regulation of cell proliferation; negative regulation of MAP kinase activity; protein binding; negative regulation of platelet-derived growth factor receptor signaling pathway;
ARAP1	5	plasma membrane; Golgi apparatus; phosphatidylinositol-3,4,5-trisphosphate binding; cytosol; protein binding;
GJA1	5	plasma membrane; Golgi apparatus; negative regulation of cell proliferation; SH3 domain binding; protein binding;

Genes shared at least 2 KEGG pathways with INPPL1 (count: 11)

Gene Symbol	Pathway Count	Pathway List
PLCD1	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD4	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3C3	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCG2	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB2	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPP5A	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB3	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PTPMT1	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4KA	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCE1	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;

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Region: chr11:71934745..71950149 View in gBrowse