ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	WASL
Symbol Alias	N-WASP, NWASP
Approved Name	Wiskott-Aldrich syndrome-like
Location	7q31.3
Position	chr7:123321989-123389121, -1
External Links	HGNC: 12735 Entrez Gene: 8976 Ensembl: ENSG00000106299 UCSC: uc003vkz.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_3	chr7:122788319-123645842 (NCBI Build 36.1 (hg18))	807966	7q31.32-7q31.33	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	molecular function	IPI	1015
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA	182
GO:0006461	protein complex assembly	biological process	IEA	32
GO:0007411	axon guidance	biological process	TAS	71
GO:0003779	actin binding	molecular function	IEA	48
GO:0051653	spindle localization	biological process	IEA	1
GO:0006928	cellular component movement	biological process	TAS[9422512]	18
GO:0030050	vesicle transport along actin filament	biological process	ISS	1
GO:0030478	actin cap	cellular component	IEA	1
GO:0051491	positive regulation of filopodium assembly	biological process	ISS	5
GO:0050999	regulation of nitric-oxide synthase activity	biological process	TAS	5
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0016050	vesicle organization	biological process	ISS	2
GO:0034629	cellular protein complex localization	biological process	IEA	1
GO:0046209	nitric oxide metabolic process	biological process	TAS	4
GO:0005829	cytosol	cellular component	TAS	485
GO:0005634	nucleus	cellular component	IEA	877
GO:2000370	positive regulation of clathrin-mediated endocytosis	biological process	ISS	2
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	ISS	23
GO:0009617	response to bacterium	biological process	IEA	4
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0030027	lamellipodium	cellular component	IEA	29
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0008154	actin polymerization or depolymerization	biological process	IEA	1
GO:0005083	small GTPase regulator activity	molecular function	IEA	6
GO:0006900	membrane budding	biological process	ISS	1
GO:0015629	actin cytoskeleton	cellular component	TAS[9422512]	30
GO:0030666	endocytic vesicle membrane	cellular component	TAS	14

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa04520	Adherens junction	15
hsa05130	Pathogenic Escherichia coli infection	17
hsa05131	EPEC	17
hsa04810	Regulation of actin cytoskeleton	49

Genes shared at least 5 GO terms with WASL (count: 37)

Gene Symbol	Pathway Count	Pathway List
APBB1	7	protein binding; regulation of transcription, DNA-dependent; axon guidance; nucleus; transcription, DNA-dependent; lamellipodium; plasma membrane;
CTNND1	7	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent; lamellipodium; plasma membrane;
PDPK1	6	protein binding; regulation of transcription, DNA-dependent; cytosol; cytoplasmic membrane-bounded vesicle; transcription, DNA-dependent; plasma membrane;
HMGA1	6	protein binding; regulation of transcription, DNA-dependent; protein complex assembly; cytosol; nucleus; transcription, DNA-dependent;
BAIAP2	6	protein binding; cytosol; nucleus; response to bacterium; plasma membrane; actin cytoskeleton;
LPXN	6	protein binding; regulation of transcription, DNA-dependent; protein complex assembly; nucleus; transcription, DNA-dependent; plasma membrane;
INPPL1	6	protein binding; actin binding; small molecule metabolic process; cytosol; lamellipodium; plasma membrane;
APC	6	protein binding; protein complex assembly; cytosol; nucleus; lamellipodium; plasma membrane;
GSN	5	protein binding; actin binding; cytosol; lamellipodium; actin cytoskeleton;
TXN	5	protein binding; cellular component movement; small molecule metabolic process; cytosol; transcription, DNA-dependent;
FLII	5	protein binding; regulation of transcription, DNA-dependent; actin binding; nucleus; transcription, DNA-dependent;
GSK3B	5	protein binding; axon guidance; cytosol; nucleus; plasma membrane;
HABP4	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent;
ARPC2	5	protein binding; actin binding; cellular component movement; plasma membrane; actin cytoskeleton;
MAPK1	5	protein binding; axon guidance; cytosol; nucleus; transcription, DNA-dependent;
ERBB2	5	protein binding; axon guidance; nucleus; transcription, DNA-dependent; plasma membrane;
HSPA8	5	protein binding; cytosol; nucleus; transcription, DNA-dependent; plasma membrane;
ARPC5	5	protein binding; actin binding; cellular component movement; lamellipodium; actin cytoskeleton;
RQCD1	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent;
CREBBP	5	protein binding; regulation of transcription, DNA-dependent; protein complex assembly; small molecule metabolic process; nucleus;
ARRB2	5	protein binding; cytosol; nucleus; cytoplasmic membrane-bounded vesicle; plasma membrane;
BIRC2	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent;
NCK1	5	protein binding; axon guidance; cytosol; nucleus; plasma membrane;
SNCA	5	protein binding; cytosol; nucleus; plasma membrane; actin cytoskeleton;
DAXX	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent;
CBL	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; plasma membrane;
TRAF7	5	protein binding; regulation of transcription, DNA-dependent; cytoplasmic membrane-bounded vesicle; transcription, DNA-dependent; plasma membrane;
PRKAA1	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent;
UBC	5	protein binding; cytosol; transcription, DNA-dependent; plasma membrane; endocytic vesicle membrane;
AXIN1	5	protein binding; cytosol; nucleus; cytoplasmic membrane-bounded vesicle; plasma membrane;
PRKD1	5	protein binding; small molecule metabolic process; cytosol; nucleus; plasma membrane;
ROCK2	5	protein binding; axon guidance; cytosol; nucleus; plasma membrane;
UBB	5	protein binding; cytosol; transcription, DNA-dependent; plasma membrane; endocytic vesicle membrane;
CNOT6	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent;
CORO1A	5	protein binding; cellular component movement; nucleus; lamellipodium; plasma membrane;
EEF1D	5	protein binding; regulation of transcription, DNA-dependent; cytosol; nucleus; transcription, DNA-dependent;
CCDC88A	5	actin binding; cytosol; cytoplasmic membrane-bounded vesicle; lamellipodium; plasma membrane;

Genes shared at least 2 KEGG pathways with WASL (count: 20)

Gene Symbol	Pathway Count	Pathway List
ARPC5	3	Pathogenic Escherichia coli infection; EPEC; Regulation of actin cytoskeleton;
ARPC5L	3	Pathogenic Escherichia coli infection; EPEC; Regulation of actin cytoskeleton;
ROCK2	3	Pathogenic Escherichia coli infection; EPEC; Regulation of actin cytoskeleton;
MAPK3	2	Adherens junction; Regulation of actin cytoskeleton;
ACTN3	2	Adherens junction; Regulation of actin cytoskeleton;
MAPK1	2	Adherens junction; Regulation of actin cytoskeleton;
BAIAP2	2	Adherens junction; Regulation of actin cytoskeleton;
ARHGEF2	2	Pathogenic Escherichia coli infection; EPEC;
CTTN	2	Pathogenic Escherichia coli infection; EPEC;
TUBA3E	2	Pathogenic Escherichia coli infection; EPEC;
TUBA3D	2	Pathogenic Escherichia coli infection; EPEC;
NCK2	2	Pathogenic Escherichia coli infection; EPEC;
NCL	2	Pathogenic Escherichia coli infection; EPEC;
TUBA4A	2	Pathogenic Escherichia coli infection; EPEC;
NCK1	2	Pathogenic Escherichia coli infection; EPEC;
YWHAQ	2	Pathogenic Escherichia coli infection; EPEC;
TUBB3	2	Pathogenic Escherichia coli infection; EPEC;
TLR4	2	Pathogenic Escherichia coli infection; EPEC;
KRT18	2	Pathogenic Escherichia coli infection; EPEC;
TUBA3C	2	Pathogenic Escherichia coli infection; EPEC;

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Region: chr7:123321989..123389121 View in gBrowse