ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TXN
Symbol Alias	TRX
Approved Name	thioredoxin
Location	9q31
Position	chr9:113006091-113018920, -
External Links	HGNC: 12435 Entrez Gene: 7295 Ensembl: ENSG00000136810 UCSC: uc004bep.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 40)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 40)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006662	glycerol ether metabolic process	Biological Process		5
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005829	cytosol	Cellular Component		447
GO:0005739	mitochondrion	Cellular Component		183
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005576	extracellular region	Cellular Component		240
GO:0005515	protein binding	Molecular Function		910
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043388	positive regulation of DNA binding	Biological Process	IDA[11118054]	3
GO:0045454	cell redox homeostasis	Biological Process		13
GO:0045087	innate immune response	Biological Process		54
GO:0035690	cellular response to drug	Biological Process		8
GO:0033158	regulation of protein import into nucleus, translocation	Biological Process	IDA[11118054]	1
GO:0043025	neuronal cell body	Cellular Component		51
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process		8
GO:0071455	cellular response to hyperoxia	Biological Process		1
GO:0071333	cellular response to glucose stimulus	Biological Process		8
GO:0097068	response to thyroxine stimulus	Biological Process		1
GO:0071548	response to dexamethasone stimulus	Biological Process		1
GO:0048678	response to axon injury	Biological Process		3
GO:0046826	negative regulation of protein export from nucleus	Biological Process		2
GO:0055114	oxidation-reduction process	Biological Process	IDA[11118054]	15
GO:0055086	nucleobase-containing small molecule metabolic process	Biological Process		9
GO:0009055	electron carrier activity	Molecular Function		18
GO:0009314	response to radiation	Biological Process	IDA[11118054]	5
GO:0010269	response to selenium ion	Biological Process		3
GO:0014823	response to activity	Biological Process		7
GO:0006928	cellular component movement	Biological Process	TAS[10947064]	16
GO:0007165	signal transduction	Biological Process	TAS[10947064]	171
GO:0007267	cell-cell signaling	Biological Process	TAS[10947064]	38
GO:0008283	cell proliferation	Biological Process	TAS[3170595]	60
GO:0019899	enzyme binding	Molecular Function		47
GO:0022900	electron transport chain	Biological Process		12
GO:0030424	axon	Cellular Component		35
GO:0030425	dendrite	Cellular Component		46
GO:0015035	protein disulfide oxidoreductase activity	Molecular Function		6
GO:0015037	peptide disulfide oxidoreductase activity	Molecular Function		1
GO:0015949	nucleobase-containing small molecule interconversion	Biological Process		2
GO:0016999	antibiotic metabolic process	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TXN (count: 42)

Gene Symbol	Pathway Count	Pathway List
CYBA	9	mitochondrion; protein binding; innate immune response; neuronal cell body; cellular response to glucose stimulus; oxidation-reduction process; electron carrier activity; electron transport chain; dendrite;
TH	8	cytosol; mitochondrion; protein binding; small molecule metabolic process; cellular response to drug; cellular response to glucose stimulus; response to activity; dendrite;
MAPK1	7	transcription, DNA-dependent; cytosol; mitochondrion; nucleoplasm; protein binding; innate immune response; signal transduction;
UBB	7	transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;
UBC	7	transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;
PYCARD	7	cytosol; mitochondrion; extracellular region; protein binding; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; signal transduction;
PDIA3	6	glycerol ether metabolic process; protein binding; cell redox homeostasis; electron carrier activity; signal transduction; protein disulfide oxidoreductase activity;
KDM1A	6	transcription, DNA-dependent; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; cell proliferation; enzyme binding;
CASP1	6	cytosol; extracellular region; protein binding; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; signal transduction;
DDC	6	cytosol; protein binding; small molecule metabolic process; cellular response to drug; neuronal cell body; axon;
PDE2A	6	cytosol; protein binding; negative regulation of transcription from RNA polymerase II promoter; cellular response to drug; axon; dendrite;
PRKD1	6	cytosol; protein binding; small molecule metabolic process; innate immune response; signal transduction; cell proliferation;
RRM2	6	cytosol; nucleoplasm; protein binding; small molecule metabolic process; nucleobase-containing small molecule metabolic process; nucleobase-containing small molecule interconversion;
SNCA	6	cytosol; mitochondrion; extracellular region; protein binding; oxidation-reduction process; axon;
ACHE	6	extracellular region; protein binding; small molecule metabolic process; cell proliferation; axon; dendrite;
PDIA6	5	glycerol ether metabolic process; protein binding; cell redox homeostasis; electron carrier activity; protein disulfide oxidoreductase activity;
TXNL1	5	glycerol ether metabolic process; cell redox homeostasis; electron carrier activity; electron transport chain; protein disulfide oxidoreductase activity;
HMGA1	5	transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; enzyme binding;
MEN1	5	transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter;
NCOR1	5	transcription, DNA-dependent; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; small molecule metabolic process;
NCOR2	5	transcription, DNA-dependent; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; small molecule metabolic process;
NEDD4L	5	transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter;
PRKAA1	5	transcription, DNA-dependent; cytosol; protein binding; response to activity; signal transduction;
WASL	5	transcription, DNA-dependent; cytosol; protein binding; small molecule metabolic process; cellular component movement;
ARG1	5	cytosol; small molecule metabolic process; neuronal cell body; response to axon injury; response to selenium ion;
IRF7	5	cytosol; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; innate immune response;
MAP2K3	5	cytosol; nucleoplasm; protein binding; innate immune response; signal transduction;
MAPK3	5	cytosol; mitochondrion; nucleoplasm; protein binding; innate immune response;
MAPK7	5	cytosol; nucleoplasm; protein binding; innate immune response; signal transduction;
MAPK9	5	cytosol; mitochondrion; nucleoplasm; protein binding; innate immune response;
MTMR2	5	cytosol; protein binding; small molecule metabolic process; axon; dendrite;
NCF2	5	cytosol; protein binding; innate immune response; electron carrier activity; response to activity;
PLK1	5	cytosol; nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; cell proliferation;
PRKAB2	5	cytosol; nucleoplasm; protein binding; small molecule metabolic process; signal transduction;
RIPK3	5	cytosol; mitochondrion; protein binding; innate immune response; signal transduction;
WWOX	5	cytosol; mitochondrion; protein binding; oxidation-reduction process; enzyme binding;
CYP2E1	5	mitochondrion; small molecule metabolic process; oxidation-reduction process; electron carrier activity; enzyme binding;
PGR	5	nucleoplasm; protein binding; signal transduction; cell-cell signaling; enzyme binding;
STRN3	5	nucleoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; neuronal cell body; dendrite;
INHA	5	extracellular region; protein binding; neuronal cell body; signal transduction; cell-cell signaling;
PTPRK	5	protein binding; neuronal cell body; signal transduction; axon; dendrite;
CNTNAP2	5	neuronal cell body; signal transduction; enzyme binding; axon; dendrite;

Genes shared at least 2 KEGG pathways with TXN (count: 0)

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Region: chr9:113006091..113018920 View in gBrowse