ADHDgene Database
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  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005739
Name mitochondrion
Type Cellular Component
No. of Genes in ADHDgene  183
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 183)

Literature-origin genes (count: 13)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
COMT catechol-O-methyltransferase 22q11.21 25(5/20/0)
PRELID2 PRELI domain containing 2 5q32 1(0/1/0)
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0)
TH tyrosine hydroxylase 11p15.5 7(2/5/0)
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 6q25.2-q27 1(1/0/0) IMP[19029340]
MOBP myelin-associated oligodendrocyte basic protein 3p21.33 1(0/0/1)
HK1 hexokinase 1 10q22 1(0/1/0)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 12q23 2(2/0/0)
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3p24.3 1(0/0/1)
CLYBL citrate lyase beta like 13q32.3 1(0/0/1)
KANK2 KN motif and ankyrin repeat domains 2 19p13.2 1(0/1/0)
NT5DC3 5'-nucleotidase domain containing 3 12q22-q23.1 1(0/0/1)
HKDC1 hexokinase domain containing 1 10q22.1 1(0/1/0)

Genes from other sources Help (count: 170)

Approved Symbol Approved Name Source Evidence[PMID]
AUH AU RNA binding protein/enoyl-CoA hydratase Mapped by significant region
CA5A carbonic anhydrase VA, mitochondrial Mapped by significant region TAS[8356065]
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 Mapped by significant region TAS[11030628]
GCSH glycine cleavage system protein H (aminomethyl carrier) Mapped by significant region
TXN thioredoxin Mapped by significant region
EFHA1 EF-hand domain family, member A1 Mapped by significant region
NOX4 NADPH oxidase 4 Mapped by significant region
SECISBP2 SECIS binding protein 2 Mapped by significant region
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS[19565474]
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) Mapped by significant region
CCDC90B coiled-coil domain containing 90B Mapped by significant region
CPT1A carnitine palmitoyltransferase 1A (liver) Mapped by CNV; Mapped by significant region
STAP1 signal transducing adaptor family member 1 Mapped by significant region IDA[17936702]
LDHD lactate dehydrogenase D Mapped by significant region
PRDX5 peroxiredoxin 5 Mapped by significant region IDA[10751410]
OXCT1 3-oxoacid CoA transferase 1 Mapped by significant region NAS[10964512]
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 Mapped by PBA pathway
RAB1B RAB1B, member RAS oncogene family Mapped by significant region
ACAT1 acetyl-CoA acetyltransferase 1 Mapped by CNV; Mapped by significant region
RPUSD4 RNA pseudouridylate synthase domain containing 4 Mapped by significant region
GLYAT glycine-N-acyltransferase Mapped by LD-proxy; Mapped by significant region
WWOX WW domain containing oxidoreductase Mapped by significant region
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) Mapped by CNV; Mapped by significant region IDA[12198123]
REXO2 REX2, RNA exonuclease 2 homolog (S. cerevisiae) Mapped by significant region
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) Mapped by PBA pathway
MRPS14 mitochondrial ribosomal protein S14 Mapped by significant region
CHRDL2 chordin-like 2 Mapped by significant region
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 Mapped by PBA pathway
DARS2 aspartyl-tRNA synthetase 2, mitochondrial Mapped by significant region TAS[15779907]
MRRF mitochondrial ribosome recycling factor Mapped by significant region
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) Mapped by CNV
DGAT2 diacylglycerol O-acyltransferase 2 Mapped by significant region
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 Mapped by significant region
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial Mapped by LD-proxy NAS[18658143]
PTS 6-pyruvoyltetrahydropterin synthase Mapped by significant region
GLYATL2 glycine-N-acyltransferase-like 2 Mapped by significant region
GLYATL1 glycine-N-acyltransferase-like 1 Mapped by significant region
CKMT1A creatine kinase, mitochondrial 1A Mapped by LD-proxy TAS[2914937]
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 Mapped by CNV
TCF25 transcription factor 25 (basic helix-loop-helix) Mapped by significant region
FOXRED1 FAD-dependent oxidoreductase domain containing 1 Mapped by significant region
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) Mapped by significant region
LYPLA1 lysophospholipase I Mapped by PBA pathway
SGK1 serum/glucocorticoid regulated kinase 1 Mapped by significant region
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G Mapped by significant region
BCS1L BCS1-like (S. cerevisiae) Mapped by significant region IDA[18628306]
DRG2 developmentally regulated GTP binding protein 2 Mapped by significant region
SRP19 signal recognition particle 19kDa Mapped by LD-proxy
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) Mapped by LD-proxy NAS[9647766]
ZBTB9 zinc finger and BTB domain containing 9 Mapped by LD-proxy
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) Mapped by significant region TAS[9635427]
HIBADH 3-hydroxyisobutyrate dehydrogenase Mapped by significant region
TMEM126A transmembrane protein 126A Mapped by significant region
GLUL glutamate-ammonia ligase Mapped by significant region
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Mapped by significant region
NDUFAF2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2 Mapped by CNV
TPP1 tripeptidyl peptidase I Mapped by CNV
FTH1 ferritin, heavy polypeptide 1 Mapped by significant region
HDDC2 HD domain containing 2 Mapped by significant region
AATK apoptosis-associated tyrosine kinase Mapped by LD-proxy
PTCD3 Pentatricopeptide repeat domain 3 Mapped by CNV IDA[19427859]
FASTKD5 FAST kinase domains 5 Mapped by CNV
C5orf54 chromosome 5 open reading frame 54 Mapped by significant region
POLD3 polymerase (DNA-directed), delta 3, accessory subunit Mapped by significant region
ACSF3 acyl-CoA synthetase family member 3 Mapped by CNV; Mapped by significant region
ACP6 acid phosphatase 6, lysophosphatidic Mapped by CNV
IREB2 iron-responsive element binding protein 2 Mapped by LD-proxy
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa Mapped by significant region
EARS2 glutamyl-tRNA synthetase 2, mitochondrial (putative) Mapped by significant region IDA[19805282]
PXMP2 peroxisomal membrane protein 2, 22kDa Mapped by CNV
MTG1 mitochondrial GTPase 1 homolog (S. cerevisiae) Mapped by CNV
AGXT2 alanine--glyoxylate aminotransferase 2 Mapped by significant region
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Mapped by CNV
ACOT13 acyl-CoA thioesterase 13 Mapped by LD-proxy
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial Mapped by CNV TAS[16130169]
TBC1D15 TBC1 domain family, member 15 Mapped by LD-proxy
NUBPL nucleotide binding protein-like Mapped by significant region IDA[19752196]
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta Mapped by PBA pathway
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 Mapped by CNV IDA[16118205]
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Mapped by CNV
FIBP fibroblast growth factor (acidic) intracellular binding protein Mapped by significant region TAS[9806903]
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial Mapped by significant region TAS[7818469]
ACSM2B acyl-CoA synthetase medium-chain family member 2B Mapped by significant region NAS[19634011]
SOD3 superoxide dismutase 3, extracellular Mapped by CNV
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 Mapped by LD-proxy; Mapped by literature SNP
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region
NARS asparaginyl-tRNA synthetase Mapped by significant region
ACSM2A acyl-CoA synthetase medium-chain family member 2A Mapped by significant region NAS[19634011]
GOLPH3 golgi phosphoprotein 3 (coat-protein) Mapped by significant region IDA[16263763]
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 Mapped by CNV
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 Mapped by significant region
SHMT1 serine hydroxymethyltransferase 1 (soluble) Mapped by significant region
BAD BCL2-associated agonist of cell death Mapped by significant region
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV TAS[9973195]
PECR peroxisomal trans-2-enoyl-CoA reductase Mapped by significant region
PYCARD PYD and CARD domain containing Mapped by CNV IDA[14730312]
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 Mapped by CNV
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) Mapped by significant region
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 Mapped by CNV
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mapped by significant region IDA[10837493,18279659]
TMEM223 transmembrane protein 223 Mapped by significant region
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 Mapped by significant region
SARS seryl-tRNA synthetase Mapped by CNV
PERP PERP, TP53 apoptosis effector Mapped by significant region
HINT3 histidine triad nucleotide binding protein 3 Mapped by significant region
RPS15A ribosomal protein S15a Mapped by significant region
HEBP2 heme binding protein 2 Mapped by significant region
MLYCD malonyl-CoA decarboxylase Mapped by CNV; Mapped by significant region
RIPK3 receptor-interacting serine-threonine kinase 3 Mapped by significant region
FASTK Fas-activated serine/threonine kinase Mapped by LD-proxy; Mapped by literature SNP
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 Mapped by LD-proxy
PC pyruvate carboxylase Mapped by significant region IDA[16729965]
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS[19565474]
COX4I1 cytochrome c oxidase subunit IV isoform 1 Mapped by significant region
BCO2 beta-carotene oxygenase 2 Mapped by significant region
SARDH sarcosine dehydrogenase Mapped by LD-proxy
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) Mapped by significant region
DCPS decapping enzyme, scavenger Mapped by significant region
CRYM crystallin, mu Mapped by significant region
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) Mapped by PBA pathway
MRPL50 mitochondrial ribosomal protein L50 Mapped by significant region
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 Mapped by LD-proxy
LIPT2 lipoyl(octanoyl) transferase 2 (putative) Mapped by significant region
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 Mapped by significant region
TXNRD2 thioredoxin reductase 2 Mapped by CNV; Mapped by LD-proxy; Mapped by literature SNP
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 Mapped by significant region IDA[15705586]
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 Mapped by significant region
GPRC5C G protein-coupled receptor, family C, group 5, member C Mapped by CNV
CCDC136 coiled-coil domain containing 136 Mapped by LD-proxy
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Mapped by significant region
MACROD1 MACRO domain containing 1 Mapped by significant region
MAPK9 mitogen-activated protein kinase 9 Mapped by CNV
LYRM1 LYR motif containing 1 Mapped by significant region
FDX1 ferredoxin 1 Mapped by significant region
BLID BH3-like motif containing, cell death inducer Mapped by significant region
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) Mapped by CNV; Mapped by significant region TAS[9180264]
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 Mapped by CNV
MRPL21 mitochondrial ribosomal protein L21 Mapped by CNV; Mapped by significant region
PON2 paraoxonase 2 Mapped by PBA pathway
C22orf29 chromosome 22 open reading frame 29 Mapped by CNV
AMACR alpha-methylacyl-CoA racemase Mapped by significant region IDA[11060344]
AKAP10 A kinase (PRKA) anchor protein 10 Mapped by significant region
MRPL16 mitochondrial ribosomal protein L16 Mapped by significant region
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K Mapped by CNV
CLPB ClpB caseinolytic peptidase B homolog (E. coli) Mapped by significant region
ACACA acetyl-CoA carboxylase alpha Mapped by CNV
BCKDK branched chain ketoacid dehydrogenase kinase Mapped by CNV TAS[11839747]
SDHAF2 succinate dehydrogenase complex assembly factor 2 Mapped by significant region
PNKD paroxysmal nonkinesigenic dyskinesia Mapped by significant region
KARS lysyl-tRNA synthetase Mapped by significant region IDA[10952987]
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein Mapped by significant region TAS[2302193]
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) Mapped by CNV
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) Mapped by CNV
ZDHHC8 zinc finger, DHHC-type containing 8 Mapped by CNV
SLMO1 slowmo homolog 1 (Drosophila) Mapped by CNV
ACAD10 acyl-CoA dehydrogenase family, member 10 Mapped by LD-proxy
GHR growth hormone receptor Mapped by CNV; Mapped by significant region
HSDL1 hydroxysteroid dehydrogenase like 1 Mapped by CNV; Mapped by significant region
METTL12 methyltransferase like 12 Mapped by significant region
RAI14 retinoic acid induced 14 Mapped by significant region
OPA1 optic atrophy 1 (autosomal dominant) Mapped by CNV IDA[17545159]
HSDL2 hydroxysteroid dehydrogenase like 2 Mapped by significant region
FEN1 flap structure-specific endonuclease 1 Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region IDA[18995831]
CRYAB crystallin, alpha B Mapped by significant region
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma Mapped by PBA pathway IDA[11278501]
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 Mapped by LD-proxy
GSTP1 glutathione S-transferase pi 1 Mapped by significant region
NT5M 5',3'-nucleotidase, mitochondrial Mapped by significant region TAS[10899995]

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014