ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol TH
Symbol Alias DYT5b
Approved Name tyrosine hydroxylase
Name Alias "tyrosine 3-monooxygenase"
Location 11p15.5
Position chr11:2185159-2193107, -1
External Links HGNC: 11782
Entrez Gene: 7054
Ensembl: ENSG00000180176
UCSC: uc001lvq.3
No. of Studies 7 (significant: 2; non-significant: 5; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 7)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Nyman ES, 2007 No evidence of association was seen. Non-significant
Payton A, 2001 there was no evidence of preferential transmission of any marker allele for the polymorphism examined in this study Non-significant
Comings DE, 1995 ADHD patient showed no significant differences in the distribution of the five repeat-size alleles compared to controls. Non-significant
Hawi Z, 2005 paternal versus maternal transmissions, 9 genes combined TDT P-value=0.0019, X2=9.6 (1df), OR=1.56; TDT P-value=0.0016, X2=9.9 when TH was removed in sensitivity analysis Non-significant
Kirley A, 2002 Nonsignificant trends of association were found for TH, but significant preferential paternal transmission of alleles at TH (allele 2) was found Significant
Barr CL, 2000 (b) no significant difference in the transmission of any of the alleles Non-significant
Ribases, M., 2012 rs2070762 in the TH gene showed nominal association in both childhood and adulthood ADHD. Significant

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 3)

LD-proxies (count: 1)


Gene related CNVs (count: 0)

Gene related other variant (count: 1)

Gene related regions (count: 0)

Gene related GO terms (count: 80)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 80)


Gene related KEGG pathways (count: 2)

Genes shared at least 5 GO terms with TH (count: 86)

Genes shared at least 2 KEGG pathways with TH (count: 0)

View in gBrowse

Region: chr11:2185159..2193107 View in gBrowse
View in gBrowse