ADHDgene Database

Gene Report

Basic Info

Approved Symbol	UCP3
Symbol Alias	SLC25A9
Approved Name	uncoupling protein 3 (mitochondrial, proton carrier)
Location	11q13.4
Position	chr11:73711326-73720282, -
External Links	HGNC: 12519 Entrez Gene: 7352 Ensembl: ENSG00000175564 UCSC: uc001our.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_7	chr11:72900000-73400000 (NCBI Build 35 (hg17))	500000	11q13.4	Duplication	Maternal (affected, also in affected sibling)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0015992	proton transport	Biological Process		6
GO:0014823	response to activity	Biological Process		7
GO:0017077	oxidative phosphorylation uncoupler activity	Molecular Function		1
GO:0016021	integral to membrane	Cellular Component		845
GO:0032868	response to insulin stimulus	Biological Process		11
GO:0022904	respiratory electron transport chain	Biological Process		15
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0032870	cellular response to hormone stimulus	Biological Process		7
GO:0006629	lipid metabolic process	Biological Process	TAS[10935638]	51
GO:0005743	mitochondrial inner membrane	Cellular Component		44
GO:0006839	mitochondrial transport	Biological Process		3
GO:0006631	fatty acid metabolic process	Biological Process		15
GO:0007584	response to nutrient	Biological Process		15
GO:0007568	aging	Biological Process		29
GO:0009409	response to cold	Biological Process		8
GO:0007585	respiratory gaseous exchange	Biological Process	TAS[9180264]	4
GO:0005215	transporter activity	Molecular Function	TAS[9196039]	41
GO:0005739	mitochondrion	Cellular Component	TAS[9180264]	183
GO:0000303	response to superoxide	Biological Process		2
GO:0001666	response to hypoxia	Biological Process		34
GO:0051384	response to glucocorticoid stimulus	Biological Process		17

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with UCP3 (count: 5)

Gene Symbol	Pathway Count	Pathway List
UCP2	8	proton transport; integral to membrane; respiratory electron transport chain; small molecule metabolic process; mitochondrial inner membrane; mitochondrial transport; response to superoxide; response to hypoxia;
TH	5	response to activity; small molecule metabolic process; fatty acid metabolic process; mitochondrion; response to hypoxia;
GHR	5	integral to membrane; cellular response to hormone stimulus; fatty acid metabolic process; mitochondrion; response to glucocorticoid stimulus;
SDHD	5	integral to membrane; respiratory electron transport chain; small molecule metabolic process; mitochondrial inner membrane; mitochondrion;
COX4I1	5	respiratory electron transport chain; small molecule metabolic process; mitochondrial inner membrane; response to nutrient; mitochondrion;

Genes shared at least 2 KEGG pathways with UCP3 (count: 0)

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Region: chr11:73711326..73720282 View in gBrowse