ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADORA2A
Previous Symbol	ADORA2
Symbol Alias	RDC8
Approved Name	adenosine A2a receptor
Location	22q11.23
Position	chr22:24813847-24838328, 1
External Links	HGNC: 263 Entrez Gene: 135 Ensembl: ENSG00000128271 UCSC: uc002zzy.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_37	chr22:22020325-23326630 (NCBI Build 36.1 (hg18))	1306306	22q11.23	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 69)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 69)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001609	G-protein coupled adenosine receptor activity	molecular function	IEA	1
GO:0035810	positive regulation of urine volume	biological process	IEA	4
GO:0007267	cell-cell signaling	biological process	TAS[7818494]	41
GO:0001963	synaptic transmission, dopaminergic	biological process	IEA	7
GO:0044446	intracellular organelle part	cellular component	IDA[16339847]	1
GO:0030673	axolemma	cellular component	IEA	3
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	biological process	IEA	10
GO:0042734	presynaptic membrane	cellular component	IEA	16
GO:0014061	regulation of norepinephrine secretion	biological process	IEA	1
GO:0007600	sensory perception	biological process	TAS[9262401]	5
GO:0042493	response to drug	biological process	IEA	73
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	18
GO:0008015	blood circulation	biological process	TAS[9262401]	12
GO:0042755	eating behavior	biological process	IEA	7
GO:0006968	cellular defense response	biological process	TAS[10051547]	12
GO:0031000	response to caffeine	biological process	IEA	6
GO:0001975	response to amphetamine	biological process	IEA	16
GO:0050714	positive regulation of protein secretion	biological process	IEA	5
GO:0007417	central nervous system development	biological process	TAS[10945659]	22
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS	16
GO:0031802	type 5 metabotropic glutamate receptor binding	molecular function	IEA	1
GO:0050728	negative regulation of inflammatory response	biological process	IEA	12
GO:0007271	synaptic transmission, cholinergic	biological process	IEA	8
GO:0035249	synaptic transmission, glutamatergic	biological process	IEA	7
GO:0007190	activation of adenylate cyclase activity	biological process	TAS	10
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA	8
GO:0032279	asymmetric synapse	cellular component	IEA	4
GO:0005887	integral to plasma membrane	cellular component	TAS[8794889]	236
GO:0043025	neuronal cell body	cellular component	IEA	56
GO:0006171	cAMP biosynthetic process	biological process	TAS[10899090]	3
GO:0046636	negative regulation of alpha-beta T cell activation	biological process	IEA	1
GO:0007626	locomotory behavior	biological process	IEA	26
GO:0048143	astrocyte activation	biological process	IEA	1
GO:0048812	neuron projection morphogenesis	biological process	IEA	8
GO:0040013	negative regulation of locomotion	biological process	IEA	2
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IEA	12
GO:0048167	regulation of synaptic plasticity	biological process	IEA	9
GO:2001235	positive regulation of apoptotic signaling pathway	biological process	IEA	2
GO:0014057	positive regulation of acetylcholine secretion	biological process	IEA	1
GO:0006469	negative regulation of protein kinase activity	biological process	IEA	17
GO:0048786	presynaptic active zone	cellular component	IEA	4
GO:0051924	regulation of calcium ion transport	biological process	IEA	9
GO:0016020	membrane	cellular component	TAS[10051547]	155
GO:0007596	blood coagulation	biological process	TAS[10899090]	85
GO:0045211	postsynaptic membrane	cellular component	IEA	45
GO:0006909	phagocytosis	biological process	TAS[8360491]	5
GO:0006915	apoptotic process	biological process	TAS[7818494]	127
GO:0006954	inflammatory response	biological process	TAS[8360491]	54
GO:0042311	vasodilation	biological process	IEA	3
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA	182
GO:0012505	endomembrane system	cellular component	IEA	20
GO:0008285	negative regulation of cell proliferation	biological process	IEA	65
GO:0051881	regulation of mitochondrial membrane potential	biological process	IEA	3
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	IEA	11
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS	51
GO:0060134	prepulse inhibition	biological process	IEA	10
GO:0043116	negative regulation of vascular permeability	biological process	IEA	4
GO:0005515	protein binding	molecular function	IPI[19632986]	1015
GO:0060079	regulation of excitatory postsynaptic membrane potential	biological process	IEA	9
GO:0060080	regulation of inhibitory postsynaptic membrane potential	biological process	IEA	5
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	IEA	4
GO:0005886	plasma membrane	cellular component	IDA[16339847]; TAS	839
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[10899090]	14
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0046982	protein heterodimerization activity	molecular function	IEA	73
GO:0035815	positive regulation of renal sodium excretion	biological process	IEA	3
GO:0051393	alpha-actinin binding	molecular function	IEA	4
GO:0019899	enzyme binding	molecular function	IPI[16339847]	54
GO:0014049	positive regulation of glutamate secretion	biological process	IEA	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	89
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with ADORA2A (count: 74)

Gene Symbol	Pathway Count	Pathway List
DRD2	12	positive regulation of urine volume; synaptic transmission, dopaminergic; response to drug; response to amphetamine; integral to plasma membrane; locomotory behavior; negative regulation of cell proliferation; prepulse inhibition; protein binding; plasma membrane; postsynaptic density; positive regulation of renal sodium excretion;
DRD1	10	synaptic transmission, dopaminergic; response to drug; response to amphetamine; activation of adenylate cyclase activity; positive regulation of synaptic transmission, glutamatergic; integral to plasma membrane; adenylate cyclase-activating G-protein coupled receptor signaling pathway; prepulse inhibition; protein binding; plasma membrane;
GRIN2A	10	presynaptic membrane; response to drug; response to amphetamine; integral to plasma membrane; regulation of synaptic plasticity; postsynaptic membrane; protein binding; regulation of excitatory postsynaptic membrane potential; plasma membrane; postsynaptic density;
DRD3	9	synaptic transmission, dopaminergic; response to drug; response to amphetamine; integral to plasma membrane; locomotory behavior; prepulse inhibition; protein binding; plasma membrane; positive regulation of renal sodium excretion;
GRIK1	9	presynaptic membrane; central nervous system development; synaptic transmission, glutamatergic; integral to plasma membrane; postsynaptic membrane; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; positive regulation of synaptic transmission, GABAergic; plasma membrane;
NTRK2	9	negative regulation of neuron apoptotic process; transmembrane receptor protein tyrosine kinase signaling pathway; activation of adenylate cyclase activity; positive regulation of synaptic transmission, glutamatergic; integral to plasma membrane; neuronal cell body; presynaptic active zone; nerve growth factor receptor signaling pathway; postsynaptic density;
ADRB1	9	activation of adenylate cyclase activity; integral to plasma membrane; regulation of calcium ion transport; apoptotic process; adenylate cyclase-activating G-protein coupled receptor signaling pathway; protein binding; regulation of inhibitory postsynaptic membrane potential; plasma membrane; protein heterodimerization activity;
GJA1	8	cell-cell signaling; integral to plasma membrane; neuron projection morphogenesis; regulation of calcium ion transport; apoptotic process; negative regulation of cell proliferation; protein binding; plasma membrane;
DRD4	8	synaptic transmission, dopaminergic; response to amphetamine; integral to plasma membrane; neuronal cell body; membrane; protein binding; regulation of inhibitory postsynaptic membrane potential; plasma membrane;
ADRA1B	7	cell-cell signaling; response to amphetamine; integral to plasma membrane; locomotory behavior; plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; protein heterodimerization activity;
ADRA1A	7	cell-cell signaling; response to drug; integral to plasma membrane; apoptotic process; negative regulation of cell proliferation; plasma membrane; protein heterodimerization activity;
CHRM1	7	protein kinase C-activating G-protein coupled receptor signaling pathway; asymmetric synapse; integral to plasma membrane; membrane; postsynaptic membrane; plasma membrane; postsynaptic density;
GRM5	7	protein kinase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane; locomotory behavior; negative regulation of locomotion; regulation of transcription, DNA-dependent; plasma membrane; postsynaptic density;
ACHE	7	presynaptic membrane; positive regulation of protein secretion; synaptic transmission, cholinergic; membrane; postsynaptic membrane; protein binding; plasma membrane;
OXTR	7	response to drug; eating behavior; response to amphetamine; positive regulation of synaptic transmission, glutamatergic; integral to plasma membrane; positive regulation of synaptic transmission, GABAergic; plasma membrane;
SLC6A3	7	response to drug; integral to plasma membrane; neuronal cell body; locomotory behavior; prepulse inhibition; protein binding; plasma membrane;
BDKRB2	7	blood circulation; transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; inflammatory response; protein binding; plasma membrane; protein heterodimerization activity;
ADRB3	7	eating behavior; activation of adenylate cyclase activity; integral to plasma membrane; adenylate cyclase-activating G-protein coupled receptor signaling pathway; protein binding; plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway;
SLC18A2	7	response to amphetamine; integral to plasma membrane; neuronal cell body; locomotory behavior; membrane; plasma membrane; enzyme binding;
CHRNA3	7	synaptic transmission, cholinergic; neuronal cell body; locomotory behavior; postsynaptic membrane; regulation of excitatory postsynaptic membrane potential; plasma membrane; postsynaptic density;
CHRNA4	7	synaptic transmission, cholinergic; neuronal cell body; locomotory behavior; membrane; postsynaptic membrane; regulation of inhibitory postsynaptic membrane potential; plasma membrane;
GRIN2B	7	integral to plasma membrane; regulation of synaptic plasticity; postsynaptic membrane; protein binding; regulation of excitatory postsynaptic membrane potential; plasma membrane; postsynaptic density;
TSC2	7	neuronal cell body; negative regulation of protein kinase activity; membrane; negative regulation of cell proliferation; nerve growth factor receptor signaling pathway; protein binding; protein heterodimerization activity;
ADCY2	7	cAMP biosynthetic process; membrane; adenylate cyclase-activating G-protein coupled receptor signaling pathway; nerve growth factor receptor signaling pathway; plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; protein heterodimerization activity;
ADCY4	7	cAMP biosynthetic process; membrane; adenylate cyclase-activating G-protein coupled receptor signaling pathway; nerve growth factor receptor signaling pathway; protein binding; plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway;
TFAP2B	6	positive regulation of urine volume; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of transcription, DNA-dependent; negative regulation of cell proliferation; protein binding; protein heterodimerization activity;
CCR5	6	cell-cell signaling; cellular defense response; integral to plasma membrane; inflammatory response; protein binding; plasma membrane;
ADRA2C	6	cell-cell signaling; integral to plasma membrane; blood coagulation; protein binding; plasma membrane; protein heterodimerization activity;
DRD5	6	synaptic transmission, dopaminergic; response to amphetamine; activation of adenylate cyclase activity; integral to plasma membrane; adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane;
GRM7	6	presynaptic membrane; asymmetric synapse; integral to plasma membrane; presynaptic active zone; postsynaptic membrane; plasma membrane;
NRXN1	6	presynaptic membrane; positive regulation of synaptic transmission, glutamatergic; integral to plasma membrane; prepulse inhibition; protein binding; plasma membrane;
OPRM1	6	sensory perception; integral to plasma membrane; locomotory behavior; negative regulation of cell proliferation; protein binding; plasma membrane;
NGF	6	response to drug; negative regulation of neuron apoptotic process; transmembrane receptor protein tyrosine kinase signaling pathway; apoptotic process; inflammatory response; nerve growth factor receptor signaling pathway;
APOA1	6	response to drug; negative regulation of inflammatory response; blood coagulation; protein binding; plasma membrane; enzyme binding;
SNCA	6	response to drug; negative regulation of neuron apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein binding; regulation of excitatory postsynaptic membrane potential; plasma membrane;
VEGFB	6	response to drug; negative regulation of neuron apoptotic process; membrane; blood coagulation; protein binding; protein heterodimerization activity;
IL6	6	response to drug; response to caffeine; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of protein kinase activity; inflammatory response; negative regulation of cell proliferation;
ILK	6	negative regulation of neuron apoptotic process; neuronal cell body; neuron projection morphogenesis; negative regulation of protein kinase activity; protein binding; plasma membrane;
ADAM8	6	negative regulation of neuron apoptotic process; positive regulation of protein secretion; integral to plasma membrane; inflammatory response; protein binding; plasma membrane;
CXCR2	6	cellular defense response; integral to plasma membrane; membrane; apoptotic process; inflammatory response; plasma membrane;
GRID2	6	synaptic transmission, glutamatergic; integral to plasma membrane; postsynaptic membrane; prepulse inhibition; regulation of excitatory postsynaptic membrane potential; plasma membrane;
ADRB2	6	activation of adenylate cyclase activity; integral to plasma membrane; adenylate cyclase-activating G-protein coupled receptor signaling pathway; protein binding; plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway;
PTPRJ	6	integral to plasma membrane; blood coagulation; negative regulation of cell proliferation; negative regulation of vascular permeability; protein binding; plasma membrane;
GRIN3A	6	neuronal cell body; membrane; postsynaptic membrane; prepulse inhibition; protein binding; postsynaptic density;
PDPK1	6	negative regulation of protein kinase activity; blood coagulation; regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; protein binding; plasma membrane;
BCL2L11	6	apoptotic process; endomembrane system; nerve growth factor receptor signaling pathway; protein binding; plasma membrane; protein heterodimerization activity;
ADRA2B	5	cell-cell signaling; integral to plasma membrane; blood coagulation; protein binding; plasma membrane;
TH	5	synaptic transmission, dopaminergic; eating behavior; response to amphetamine; locomotory behavior; protein binding;
PICK1	5	protein kinase C-activating G-protein coupled receptor signaling pathway; presynaptic membrane; protein binding; plasma membrane; enzyme binding;
EDNRA	5	protein kinase C-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; integral to plasma membrane; membrane; plasma membrane;
FOSL1	5	presynaptic membrane; response to drug; cellular defense response; negative regulation of cell proliferation; protein binding;
PDE2A	5	presynaptic membrane; blood coagulation; negative regulation of vascular permeability; protein binding; plasma membrane;
ADAM17	5	response to drug; integral to plasma membrane; nerve growth factor receptor signaling pathway; protein binding; plasma membrane;
RELA	5	response to drug; cellular defense response; inflammatory response; nerve growth factor receptor signaling pathway; protein binding;
SLC6A4	5	response to drug; integral to plasma membrane; endomembrane system; protein binding; plasma membrane;
BAD	5	response to drug; apoptotic process; nerve growth factor receptor signaling pathway; protein binding; protein heterodimerization activity;
CYBA	5	response to drug; neuronal cell body; inflammatory response; protein binding; protein heterodimerization activity;
TJP1	5	response to drug; apoptotic process; negative regulation of vascular permeability; protein binding; plasma membrane;
GSK3B	5	response to drug; neuronal cell body; nerve growth factor receptor signaling pathway; protein binding; plasma membrane;
GNAL	5	response to caffeine; response to amphetamine; activation of adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane;
SHC3	5	central nervous system development; transmembrane receptor protein tyrosine kinase signaling pathway; synaptic transmission, glutamatergic; nerve growth factor receptor signaling pathway; protein binding;
MUSK	5	transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; postsynaptic membrane; regulation of transcription, DNA-dependent; protein binding;
CHRNB4	5	synaptic transmission, cholinergic; integral to plasma membrane; locomotory behavior; postsynaptic membrane; plasma membrane;
NLGN1	5	positive regulation of synaptic transmission, glutamatergic; integral to plasma membrane; postsynaptic membrane; positive regulation of synaptic transmission, GABAergic; postsynaptic density;
ADRA2A	5	integral to plasma membrane; blood coagulation; protein binding; plasma membrane; protein heterodimerization activity;
PRKD1	5	integral to plasma membrane; apoptotic process; inflammatory response; protein binding; plasma membrane;
RTN4	5	neuronal cell body; apoptotic process; nerve growth factor receptor signaling pathway; protein binding; plasma membrane;
CACNA1C	5	neuronal cell body; protein binding; plasma membrane; postsynaptic density; alpha-actinin binding;
DNAJA3	5	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of protein kinase activity; postsynaptic membrane; negative regulation of cell proliferation; protein binding;
VEGFA	5	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; membrane; blood coagulation; protein binding; protein heterodimerization activity;
GOPC	5	membrane; postsynaptic membrane; protein binding; plasma membrane; postsynaptic density;
PIK3CG	5	membrane; blood coagulation; inflammatory response; protein binding; plasma membrane;
ARRB2	5	blood coagulation; postsynaptic membrane; protein binding; plasma membrane; postsynaptic density;
AXIN1	5	apoptotic process; protein binding; plasma membrane; postsynaptic density; enzyme binding;

Genes shared at least 2 KEGG pathways with ADORA2A (count: 28)

Gene Symbol	Pathway Count	Pathway List
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr22:24813847..24838328 View in gBrowse