ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol HTR2C
Previous Symbol HTR1C
Symbol Alias 5-HT2C, 5HTR2C
Approved Name 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Previous Name "5-hydroxytryptamine (serotonin) receptor 2C"
Location Xq23
Position chrX:113818551-114144624, 1
External Links HGNC: 5295
Entrez Gene: 3358
Ensembl: ENSG00000147246
UCSC: uc004epu.1
No. of Studies 5 (significant: 2; non-significant: 3; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 5)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Li J, 2006(a) haplotype -759C/-697G TDT P-value=0.008, X2=7.067, haplotype -759T/-697C TDT P-value=0.034, X2=4.481 in ADHD; haplotype -759C/-697G TDT P-value=0.043, X2=4.083 in ADHD-C, significant evidence for biased transmission Significant
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Xu X, 2009(a) haplotype analysis: 3df, P-value=0.210. 1 SNP in this gene shown association with ADHD. But haplotype analysis of the two markers revealed no significantly increased transmission of any haplotype to ADHD. Significant
Brookes K, 2006 UNPHASED TDT P-value=0.248, global P-value=0.677, no SNP with nominal P-value<0.05 located in this gene Non-significant
Ribases M, 2009(b) little evidence of association with ADHD was found. Non-significant

Gene related SNPs (count: 208)

Literature-origin SNPs (count: 3)

LD-proxies (count: 205)


Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)


Gene related KEGG pathways (count: 3)

Genes shared at least 5 GO terms with HTR2C (count: 7)

Genes shared at least 2 KEGG pathways with HTR2C (count: 38)

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Region: chrX:113818551..114144624 View in gBrowse
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