ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADRB3
Approved Name	adrenergic, beta-3-, receptor
Location	8p12
Position	chr8:37820513-37824483, -
External Links	HGNC: 288 Entrez Gene: 155 Ensembl: ENSG00000188778 UCSC: uc003xkr.1
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.218, global P-value=0.838, WHAP TDT P_sum P-value=0.697, no SNP with nominal P-value<0.05 located in this gene	Non-significant
Hawi, Z., 2012	This gene did not show significant association with ADHD.	Non-significant

Gene related SNPs (count: 5)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs9694197	Chr8:37820093(Fwd)	downstream_gene_variant	1(0/1/0)
rs4998	Chr8:37821486(Fwd)	3_prime_UTR_variant; nc_transcript_variant; non_coding_exon_variant	1(0/1/0)

LD-proxies (count: 3)

rs_ID	Location	Functional Annotation
rs9693898	Chr8:37819176(Fwd)	downstream_gene_variant
rs4994	Chr8:37823798(Fwd)	missense_variant; upstream_gene_variant
rs4448322	Chr8:37829059(Fwd)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0040015	negative regulation of multicellular organism growth	Biological Process		6
GO:0042755	eating behavior	Biological Process		7
GO:0042803	protein homodimerization activity	Molecular Function	IDA[15123695]	113
GO:0043235	receptor complex	Cellular Component	IDA[15123695]	11
GO:0043410	positive regulation of MAPK cascade	Biological Process	IDA[15123695]	17
GO:0046677	response to antibiotic	Biological Process		4
GO:0050873	brown fat cell differentiation	Biological Process		5
GO:0051379	epinephrine binding	Molecular Function		5
GO:0051380	norepinephrine binding	Molecular Function	IDA[15123695]	4
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	Biological Process	TAS[1718744]	13
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	Biological Process		8
GO:0007190	activation of adenylate cyclase activity	Biological Process	IDA[15123695]	9
GO:0007568	aging	Biological Process		29
GO:0009409	response to cold	Biological Process		8
GO:0015052	beta3-adrenergic receptor activity	Molecular Function	IMP[9892244]	1
GO:0031649	heat generation	Biological Process		3
GO:0031699	beta-3 adrenergic receptor binding	Molecular Function		1
GO:0005886	plasma membrane	Cellular Component		772
GO:0005634	nucleus	Cellular Component		770
GO:0005975	carbohydrate metabolic process	Biological Process	TAS[2570461]	50
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1718744]	220
GO:0006112	energy reserve metabolic process	Biological Process	TAS[1718744]	25
GO:0006091	generation of precursor metabolites and energy	Biological Process	TAS[2570461]	7
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[2570461]	18
GO:0006898	receptor-mediated endocytosis	Biological Process	IDA[15123695]	11
GO:0002024	diet induced thermogenesis	Biological Process		4
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	Biological Process	IDA[15123695]	3
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	Biological Process		3
GO:0005515	protein binding	Molecular Function	IPI[15123695]	910
GO:0004939	beta-adrenergic receptor activity	Molecular Function	IDA[15123695]	2

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04970	Salivary secretion	22	Saliva has manifold functions in maintaining the integrity o...... Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP. More...

Genes shared at least 5 GO terms with ADRB3 (count: 15)

Gene Symbol	Pathway Count	Pathway List
ADRB2	19	negative regulation of multicellular organism growth; protein homodimerization activity; receptor complex; positive regulation of MAPK cascade; brown fat cell differentiation; norepinephrine binding; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; response to cold; heat generation; plasma membrane; nucleus; integral to plasma membrane; receptor-mediated endocytosis; diet induced thermogenesis; desensitization of G-protein coupled receptor protein signaling pathway by arrestin; vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure; protein binding;
ADRB1	16	negative regulation of multicellular organism growth; brown fat cell differentiation; epinephrine binding; norepinephrine binding; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; aging; response to cold; heat generation; plasma membrane; nucleus; integral to plasma membrane; diet induced thermogenesis; vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure; protein binding; beta-adrenergic receptor activity;
ADRA2A	8	protein homodimerization activity; receptor complex; epinephrine binding; norepinephrine binding; plasma membrane; integral to plasma membrane; energy reserve metabolic process; protein binding;
ADORA2A	7	eating behavior; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; plasma membrane; integral to plasma membrane; protein binding;
DRD1	7	adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; plasma membrane; nucleus; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; protein binding;
ADRA2C	6	protein homodimerization activity; epinephrine binding; plasma membrane; integral to plasma membrane; energy reserve metabolic process; protein binding;
GHR	6	protein homodimerization activity; receptor complex; plasma membrane; nucleus; integral to plasma membrane; protein binding;
MC4R	6	adenylate cyclase-modulating G-protein coupled receptor signaling pathway; plasma membrane; nucleus; energy reserve metabolic process; diet induced thermogenesis; protein binding;
CRYAB	5	protein homodimerization activity; aging; plasma membrane; nucleus; protein binding;
NTRK2	5	protein homodimerization activity; positive regulation of MAPK cascade; activation of adenylate cyclase activity; aging; integral to plasma membrane;
ADRA1A	5	positive regulation of MAPK cascade; aging; plasma membrane; nucleus; integral to plasma membrane;
ADRA1B	5	positive regulation of MAPK cascade; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; plasma membrane; nucleus; integral to plasma membrane;
FLT4	5	positive regulation of MAPK cascade; plasma membrane; nucleus; integral to plasma membrane; protein binding;
ADCY4	5	adenylate cyclase-modulating G-protein coupled receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane; energy reserve metabolic process; protein binding;
CNR1	5	adenylate cyclase-modulating G-protein coupled receptor signaling pathway; aging; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;

Genes shared at least 2 KEGG pathways with ADRB3 (count: 39)

Gene Symbol	Pathway Count	Pathway List
ADRB1	4	Endocytosis; Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRB2	4	Endocytosis; Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRA1A	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRA1B	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRA1D	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
CHRM3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADCY4	2	Calcium signaling pathway; Salivary secretion;
ATP2B3	2	Calcium signaling pathway; Salivary secretion;
ITPR1	2	Calcium signaling pathway; Salivary secretion;
ITPR2	2	Calcium signaling pathway; Salivary secretion;
NOS1	2	Calcium signaling pathway; Salivary secretion;
PLCB2	2	Calcium signaling pathway; Salivary secretion;
PLCB3	2	Calcium signaling pathway; Salivary secretion;
PRKCB	2	Calcium signaling pathway; Salivary secretion;
RYR3	2	Calcium signaling pathway; Salivary secretion;

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Region: chr8:37820513..37824483 View in gBrowse