ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRM1
Symbol Alias	GPRC1A, mGlu1, MGLUR1
Approved Name	glutamate receptor, metabotropic 1
Location	6q24
Position	chr6:146348782-146758734, 1
External Links	HGNC: 4593 Entrez Gene: 2911 Ensembl: ENSG00000152822 UCSC: uc010khw.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Elia, J., 2012	This gene was found directly affected by CNVRs overrepresented in individuals with ADHD.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2012]_4	chr6:146657076-146694047 (NCBI36 / hg18)	36972	6q24.3	Dup	2:0:0(100%)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005887	integral to plasma membrane	cellular component	TAS[7476890]	236
GO:0007626	locomotory behavior	biological process	IEA	26
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[7476890]	77
GO:0051930	regulation of sensory perception of pain	biological process	IEA	4
GO:0000186	activation of MAPKK activity	biological process	IEA	9
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[7476890]	236
GO:0008219	cell death	biological process	IEA	33
GO:0000187	activation of MAPK activity	biological process	IEA	22
GO:0007268	synaptic transmission	biological process	TAS[9076744]	103
GO:0008066	glutamate receptor activity	molecular function	TAS[7476890]	6
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0071257	cellular response to electrical stimulus	biological process	IEA	2
GO:0005634	nucleus	cellular component	IEA	877
GO:0019233	sensory perception of pain	biological process	IEA	18
GO:0014069	postsynaptic density	cellular component	IEA	26

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa04720	Long-term potentiation	16
hsa04730	Long-term depression	27
hsa04540	Gap junction	30
hsa04080	Neuroactive ligand-receptor interaction	89
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with GRM1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
GRM5	7	integral to plasma membrane; locomotory behavior; G-protein coupled receptor activity; synaptic transmission; glutamate receptor activity; plasma membrane; postsynaptic density;
GRIN2A	6	integral to plasma membrane; regulation of sensory perception of pain; synaptic transmission; plasma membrane; sensory perception of pain; postsynaptic density;
GRM6	6	integral to plasma membrane; locomotory behavior; G-protein coupled receptor activity; synaptic transmission; glutamate receptor activity; plasma membrane;
SLC6A3	5	integral to plasma membrane; locomotory behavior; cell death; synaptic transmission; plasma membrane;
LPAR1	5	integral to plasma membrane; G-protein coupled receptor signaling pathway; G-protein coupled receptor activity; activation of MAPK activity; plasma membrane;
HTR2A	5	integral to plasma membrane; cell death; synaptic transmission; plasma membrane; sensory perception of pain;
HTR1E	5	integral to plasma membrane; G-protein coupled receptor signaling pathway; G-protein coupled receptor activity; synaptic transmission; plasma membrane;
ADRA1B	5	integral to plasma membrane; locomotory behavior; G-protein coupled receptor signaling pathway; plasma membrane; nucleus;
OPRM1	5	integral to plasma membrane; locomotory behavior; G-protein coupled receptor activity; plasma membrane; sensory perception of pain;
MAPK1	5	activation of MAPKK activity; activation of MAPK activity; synaptic transmission; nucleus; sensory perception of pain;

Genes shared at least 2 KEGG pathways with GRM1 (count: 50)

Gene Symbol	Pathway Count	Pathway List
GRM5	5	Long-term potentiation; Long-term depression; Gap junction; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ITPR2	4	Long-term potentiation; Long-term depression; Gap junction; Calcium signaling pathway;
PLCB2	4	Long-term potentiation; Long-term depression; Gap junction; Calcium signaling pathway;
ITPR1	4	Long-term potentiation; Long-term depression; Gap junction; Calcium signaling pathway;
PLCB3	4	Long-term potentiation; Long-term depression; Gap junction; Calcium signaling pathway;
MAPK3	3	Long-term potentiation; Long-term depression; Gap junction;
ADCY3	3	Long-term potentiation; Gap junction; Calcium signaling pathway;
GRIN2A	3	Long-term potentiation; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
MAPK1	3	Long-term potentiation; Long-term depression; Gap junction;
ADRB1	3	Gap junction; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	3	Gap junction; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	3	Gap junction; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	3	Gap junction; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CACNA1C	2	Long-term potentiation; Calcium signaling pathway;
GRIN2B	2	Long-term potentiation; Neuroactive ligand-receptor interaction;
PPP3R2	2	Long-term potentiation; Calcium signaling pathway;
CAMK2D	2	Long-term potentiation; Calcium signaling pathway;
GUCY1A2	2	Long-term depression; Gap junction;
RYR1	2	Long-term depression; Calcium signaling pathway;
CACNA1A	2	Long-term depression; Calcium signaling pathway;
NOS1	2	Long-term depression; Calcium signaling pathway;
PRKG1	2	Long-term depression; Gap junction;
GRID2	2	Long-term depression; Neuroactive ligand-receptor interaction;
ADCY4	2	Gap junction; Calcium signaling pathway;
LPAR1	2	Gap junction; Neuroactive ligand-receptor interaction;
ADCY2	2	Gap junction; Calcium signaling pathway;
ADCY9	2	Gap junction; Calcium signaling pathway;
DRD2	2	Gap junction; Neuroactive ligand-receptor interaction;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr6:146348782..146758734 View in gBrowse