ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GRM8
Symbol Alias	GLUR8, GPRC1H, mGlu8, MGLUR8
Approved Name	glutamate receptor, metabotropic 8
Location	7q31.3-q32.1
Position	chr7:126078652-126893348, -
External Links	HGNC: 4600 Entrez Gene: 2918 Ensembl: ENSG00000179603 UCSC: uc003vlr.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Elia, J., 2012	This gene was found directly affected by CNVRs overrepresented in individuals with ADHD.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2012]_2	chr7:126441593-126621501 (NCBI36 / hg18)	179909	7q31.33	Del	0:1:0(100%)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030818	negative regulation of cAMP biosynthetic process	Biological Process	IDA[11166323]	7
GO:0008066	glutamate receptor activity	Molecular Function	TAS[9473604]	6
GO:0007608	sensory perception of smell	Biological Process		19
GO:0007601	visual perception	Biological Process	TAS[9473604]	30
GO:0007194	negative regulation of adenylate cyclase activity	Biological Process	TAS[9473604]	10
GO:0001642	group III metabotropic glutamate receptor activity	Molecular Function		2
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[9473604]	236
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9473604]	220

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with GRM8 (count: 2)

Gene Symbol	Pathway Count	Pathway List
GRM7	7	negative regulation of cAMP biosynthetic process; glutamate receptor activity; sensory perception of smell; negative regulation of adenylate cyclase activity; group III metabotropic glutamate receptor activity; plasma membrane; integral to plasma membrane;
GRM6	5	glutamate receptor activity; visual perception; G-protein coupled receptor activity; plasma membrane; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with GRM8 (count: 10)

Gene Symbol	Pathway Count	Pathway List
GRIA4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIK1	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIK4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2A	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2B	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN3A	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM1	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM5	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM6	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM7	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;

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Region: chr7:126078652..126893348 View in gBrowse