ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GRM8
Symbol Alias	GLUR8, GPRC1H, mGlu8, MGLUR8
Approved Name	glutamate receptor, metabotropic 8
Location	7q31.3-q32.1
Position	chr7:126078652-126893348, -1
External Links	HGNC: 4600 Entrez Gene: 2918 Ensembl: ENSG00000179603 UCSC: uc003vlr.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Elia, J., 2012	This gene was found directly affected by CNVRs overrepresented in individuals with ADHD.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2012]_2	chr7:126441593-126621501 (NCBI36 / hg18)	179909	7q31.33	Del	0:1:0(100%)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0007601	visual perception	biological process	TAS[9473604]	29
GO:0007194	negative regulation of adenylate cyclase activity	biological process	TAS[9473604]	10
GO:0008066	glutamate receptor activity	molecular function	TAS[9473604]	6
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IDA[11166323]	7
GO:0001642	group III metabotropic glutamate receptor activity	molecular function	IEA	2
GO:0007608	sensory perception of smell	biological process	IEA	18
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[9473604]	236
GO:0005887	integral to plasma membrane	cellular component	TAS[9473604]	236

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	89

Genes shared at least 5 GO terms with GRM8 (count: 2)

Gene Symbol	Pathway Count	Pathway List
GRM7	7	plasma membrane; negative regulation of adenylate cyclase activity; glutamate receptor activity; negative regulation of cAMP biosynthetic process; group III metabotropic glutamate receptor activity; sensory perception of smell; integral to plasma membrane;
GRM6	5	plasma membrane; visual perception; glutamate receptor activity; G-protein coupled receptor activity; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with GRM8 (count: 0)

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Region: chr7:126078652..126893348 View in gBrowse