Gene Report
Basic Info
Approved Symbol |
GRIN3A
|
Approved Name |
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Location |
9q |
Position |
chr9:104331634-104500862, - |
External Links |
HGNC: 16767
Entrez Gene: 116443
Ensembl: ENSG00000198785
UCSC: uc004bbp.1
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 23)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04080 |
Neuroactive ligand-receptor interaction |
93 |
|
hsa04724 |
Glutamatergic synapse |
43 |
Glutamate is the major excitatory neurotransmitter in the ma......
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate.
More...
|
Genes shared at least 5 GO terms with GRIN3A (count: 17)
Genes shared at least 2 KEGG pathways with GRIN3A (count: 10)
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