ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRIN3A
Symbol Alias	GluN3A
Approved Name	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Location	9q31.1
Position	chr9:104331635-104500862, -1
External Links	HGNC: 16767 Entrez Gene: 116443 Ensembl: ENSG00000198785 UCSC: uc004bbp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	molecular function	IEA	20

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045202	synapse	cellular component	IDA[17658481]	35
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	cellular component	IDA[17997397]	4
GO:0043005	neuron projection	cellular component	IDA[17658481]	38
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity	molecular function	IDA[17502428]; ISS	3
GO:0060134	prepulse inhibition	biological process	IEA	10
GO:0016021	integral to membrane	cellular component	NAS[11880201]	932
GO:0045471	response to ethanol	biological process	IDA[18445116]	18
GO:0016358	dendrite development	biological process	IEA	9
GO:0030054	cell junction	cellular component	IEA	84
GO:0045211	postsynaptic membrane	cellular component	IEA	45
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA	8
GO:0043025	neuronal cell body	cellular component	IDA[17658481]	56
GO:0006816	calcium ion transport	biological process	ISS	32
GO:0042165	neurotransmitter binding	molecular function	IEA	1
GO:0048511	rhythmic process	biological process	IEA	2
GO:0030288	outer membrane-bounded periplasmic space	cellular component	IEA	4
GO:0016020	membrane	cellular component	IDA[17997397]	155
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0051721	protein phosphatase 2A binding	molecular function	ISS	5
GO:0042802	identical protein binding	molecular function	IPI[17997397]	77
GO:0005515	protein binding	molecular function	IPI[17658481]	1015
GO:0016594	glycine binding	molecular function	IDA[17320117]	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	89

Genes shared at least 5 GO terms with GRIN3A (count: 16)

Gene Symbol	Pathway Count	Pathway List
GRIN2B	12	N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; N-methyl-D-aspartate selective glutamate receptor activity; response to ethanol; cell junction; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; outer membrane-bounded periplasmic space; postsynaptic density; calcium channel activity; protein binding; glycine binding;
GRIN2A	10	N-methyl-D-aspartate selective glutamate receptor complex; N-methyl-D-aspartate selective glutamate receptor activity; response to ethanol; cell junction; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; outer membrane-bounded periplasmic space; postsynaptic density; calcium channel activity; protein binding;
GRID2	6	synapse; prepulse inhibition; cell junction; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; outer membrane-bounded periplasmic space;
ADORA2A	6	prepulse inhibition; postsynaptic membrane; neuronal cell body; membrane; postsynaptic density; protein binding;
CHRNA4	6	integral to membrane; cell junction; postsynaptic membrane; neuronal cell body; calcium ion transport; membrane;
SNAP25	5	synapse; neuron projection; cell junction; membrane; protein binding;
NLGN1	5	synapse; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; postsynaptic membrane; postsynaptic density;
ACHE	5	synapse; cell junction; postsynaptic membrane; membrane; protein binding;
SHANK2	5	neuron projection; cell junction; postsynaptic membrane; postsynaptic density; protein binding;
SYT1	5	neuron projection; integral to membrane; cell junction; identical protein binding; protein binding;
BAIAP2	5	neuron projection; dendrite development; cell junction; identical protein binding; protein binding;
SLC6A3	5	prepulse inhibition; integral to membrane; response to ethanol; neuronal cell body; protein binding;
CHRNA3	5	integral to membrane; cell junction; postsynaptic membrane; neuronal cell body; postsynaptic density;
PLN	5	integral to membrane; calcium ion transport; membrane; identical protein binding; protein binding;
GOPC	5	cell junction; postsynaptic membrane; membrane; postsynaptic density; protein binding;
RYR2	5	calcium ion transport; membrane; identical protein binding; calcium channel activity; protein binding;

Genes shared at least 2 KEGG pathways with GRIN3A (count: 0)

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Region: chr9:104331635..104500862 View in gBrowse