ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0045202
Name	synapse
Type	Cellular Component
No. of Genes in ADHDgene	31
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 31)

Literature-origin genes (count: 9)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	14q22.3	1(0/1/0)
MAP1B	microtubule-associated protein 1B	5q13	1(0/0/1)
GRID2	glutamate receptor, ionotropic, delta 2	4q22	1(0/0/1)
CPLX1	complexin 1	4p16.3	1(1/0/0)
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	18(13/5/0)
CPLX2	complexin 2	5q35.2	2(1/0/1)
CPLX4	complexin 4	18q21.32	1(1/0/0)
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	7q21	1(0/0/1)
ADRA2A	adrenergic, alpha-2A-, receptor	10q24-q26	12(4/8/0)

Genes from other sources (count: 22)

Approved Symbol	Approved Name	Source	Evidence[PMID]
GRIN3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	Mapped by significant region	IDA[17658481]
SNAP23	synaptosomal-associated protein, 23kDa	Mapped by PBA pathway
NMNAT2	nicotinamide nucleotide adenylyltransferase 2	Mapped by significant region
MYO7A	myosin VIIA	Mapped by significant region	IDA[8842737]
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	Mapped by CNV	IDA[12843239]
CYFIP2	cytoplasmic FMR1 interacting protein 2	Mapped by significant region	IDA[11438699]
MGLL	monoglyceride lipase	Mapped by PBA pathway
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway	IDA[17658481]
TRAPPC4	trafficking protein particle complex 4	Mapped by significant region	ISS[11018053]
CACNB4	calcium channel, voltage-dependent, beta 4 subunit	Mapped by PBA pathway	IDA[16525042]
SNAP29	synaptosomal-associated protein, 29kDa	Mapped by CNV
CYFIP1	cytoplasmic FMR1 interacting protein 1	Mapped by significant region
CABP4	calcium binding protein 4	Mapped by significant region	TAS[16960802]
VWC2L	von Willebrand factor C domain containing protein 2-like	Mapped by significant region
ACHE	acetylcholinesterase	Mapped by PBA pathway	IDA[8460160]
EGFLAM	EGF-like, fibronectin type III and laminin G domains	Mapped by significant region
PRRT2	proline-rich transmembrane protein 2	Mapped by CNV
DTNA	dystrobrevin, alpha	Mapped by significant region
RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	Mapped by significant region
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	Mapped by significant region
NLGN1	neuroligin 1	Mapped by CNV
CBLN3	cerebellin 3 precursor	Mapped by significant region