ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DACT1
Symbol Alias	DAPPER1, THYEX3, HDPR1, DAPPER, FRODO
Approved Name	dishevelled-binding antagonist of beta-catenin 1
Previous Name	"dapper homolog 1, antagonist of beta-catenin (xenopus)", "dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)"
Location	14q22.3
Position	chr14:59100685-59115039, 1
External Links	HGNC: 17748 Entrez Gene: 51339 Ensembl: ENSG00000165617 UCSC: uc001xdw.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(a)	No available data. No significant association with ADHD was found.	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030877	beta-catenin destruction complex	cellular component	IDA; IDA	5
GO:0050808	synapse organization	biological process	IEA	7
GO:0046329	negative regulation of JNK cascade	biological process	IDA[17197390]	5
GO:0008013	beta-catenin binding	molecular function	IDA	12
GO:0005080	protein kinase C binding	molecular function	ISS	10
GO:0045600	positive regulation of fat cell differentiation	biological process	IEA	5
GO:0005515	protein binding	molecular function	IPI	1015
GO:0045202	synapse	cellular component	IEA	35
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	biological process	IEA	16
GO:2000095	regulation of Wnt receptor signaling pathway, planar cell polarity pathway	biological process	ISS	1
GO:0031647	regulation of protein stability	biological process	IDA	4
GO:0035413	positive regulation of catenin import into nucleus	biological process	IMP[15580286]	1
GO:0001702	gastrulation with mouth forming second	biological process	IEA	6
GO:0005634	nucleus	cellular component	IEA	877
GO:0035412	regulation of catenin import into nucleus	biological process	IMP[18936100]	2
GO:0048619	embryonic hindgut morphogenesis	biological process	ISS	1
GO:0016055	Wnt receptor signaling pathway	biological process	IEA	25
GO:0045732	positive regulation of protein catabolic process	biological process	IDA[16446366]	9
GO:0030178	negative regulation of Wnt receptor signaling pathway	biological process	IDA[17197390]; IGI[16446366]; IMP[18936100]	11
GO:1900107	regulation of nodal signaling pathway	biological process	IDA[17197390]	1
GO:0048813	dendrite morphogenesis	biological process	IEA	8
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[18936100]	90
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	biological process	IDA[18936100]	2
GO:0070097	delta-catenin binding	molecular function	ISS	2
GO:0051018	protein kinase A binding	molecular function	IDA	2
GO:0030177	positive regulation of Wnt receptor signaling pathway	biological process	IDA	3
GO:0030054	cell junction	cellular component	IEA	84

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DACT1 (count: 12)

Gene Symbol	Pathway Count	Pathway List
AXIN1	9	beta-catenin destruction complex; beta-catenin binding; protein binding; cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; nucleus; regulation of catenin import into nucleus; positive regulation of protein catabolic process; negative regulation of Wnt receptor signaling pathway;
GSK3B	7	beta-catenin destruction complex; beta-catenin binding; protein binding; cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; nucleus; positive regulation of protein catabolic process;
APC	7	beta-catenin destruction complex; beta-catenin binding; protein binding; cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; nucleus; positive regulation of protein catabolic process;
SNCA	5	synapse organization; protein binding; cytoplasm; nucleus; cell junction;
MEN1	5	negative regulation of JNK cascade; protein binding; cytoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter;
PICK1	5	protein kinase C binding; protein binding; synapse; cytoplasm; cell junction;
ID2	5	positive regulation of fat cell differentiation; protein binding; cytoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter;
UBE2I	5	protein binding; synapse; cytoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter;
INVS	5	protein binding; cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; nucleus; Wnt receptor signaling pathway;
DNAJA3	5	protein binding; cytoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter; cell junction;
CTNND1	5	protein binding; cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; nucleus; Wnt receptor signaling pathway;
WWOX	5	protein binding; cytoplasm; nucleus; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway;

Genes shared at least 2 KEGG pathways with DACT1 (count: 0)

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Region: chr14:59100685..59115039 View in gBrowse