ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	APC
Symbol Alias	DP2, DP3, DP2.5, PPP1R46
Approved Name	adenomatous polyposis coli
Previous Name	"adenomatosis polyposis coli"
Name Alias	"protein phosphatase 1, regulatory subunit 46"
Location	5q21-q22
Position	chr5:112043195-112181936, 1
External Links	HGNC: 583 Entrez Gene: 324 Ensembl: ENSG00000134982 UCSC: uc003kpy.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 21)

Literature-origin SNPs (count: 0)

LD-proxies (count: 21)

rs_ID	Location	Functional Annotation
rs2545165	chr5:112153119(Fwd)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2545169	chr5:112149757(Fwd)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2952615	chr5:112138888(Fwd)	intron_variant; NMD_transcript_variant
rs2431238	chr5:112124369(Fwd)	intron_variant; NMD_transcript_variant
rs2464805	chr5:112101793(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs497844	chr5:112185491(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs465899	chr5:112177171(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant; synonymous_variant
rs866006	chr5:112176559(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant; synonymous_variant
rs42427	chr5:112176325(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant; synonymous_variant
rs41115	chr5:112175770(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant; synonymous_variant
rs351771	chr5:112164561(Fwd)	3_prime_UTR_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; synonymous_variant
rs501250	chr5:112155793(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs464708	chr5:112154303(Fwd)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2545162	chr5:112158431(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs2909786	chr5:112168065(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs2909787	chr5:112168130(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs411356	chr5:112172219(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs2909958	chr5:112167941(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
rs2439591	chr5:112089480(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs565453	chr5:112185393(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs481789	chr5:112186064(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 71)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 71)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0033077	T cell differentiation in thymus	biological process	IEA	4
GO:0007094	mitotic cell cycle spindle assembly checkpoint	biological process	IMP[17227893]	7
GO:0032886	regulation of microtubule-based process	biological process	IMP	5
GO:0051781	positive regulation of cell division	biological process	IEA	12
GO:0031116	positive regulation of microtubule polymerization	biological process	IEA	6
GO:0030858	positive regulation of epithelial cell differentiation	biological process	IEA	1
GO:0006974	response to DNA damage stimulus	biological process	IDA[14728717]	41
GO:0046716	muscle cell homeostasis	biological process	IEA	4
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	biological process	IGI[12952940]	16
GO:0008017	microtubule binding	molecular function	IDA[16188939]	34
GO:0031274	positive regulation of pseudopodium assembly	biological process	IMP[17192415]	3
GO:0051276	chromosome organization	biological process	IEA	5
GO:0051171	regulation of nitrogen compound metabolic process	biological process	IEA	1
GO:0030877	beta-catenin destruction complex	cellular component	IDA[16188939]	5
GO:0030335	positive regulation of cell migration	biological process	IMP[17192415]	28
GO:0007409	axonogenesis	biological process	IEA	15
GO:0045296	cadherin binding	molecular function	IDA[7890674]	9
GO:0000776	kinetochore	cellular component	IDA[11283619]	19
GO:0005829	cytosol	cellular component	TAS	485
GO:0035371	microtubule plus end	cellular component	IEA	3
GO:0008013	beta-catenin binding	molecular function	IPI[7890674]	12
GO:0045732	positive regulation of protein catabolic process	biological process	IC[16188939]; IGI[12952940]	9
GO:0009798	axis specification	biological process	IEA	4
GO:0043066	negative regulation of apoptotic process	biological process	IEA	85
GO:0019901	protein kinase binding	molecular function	IPI[8638126]	59
GO:0044295	axonal growth cone	cellular component	IEA	3
GO:0031122	cytoplasmic microtubule organization	biological process	IEA	4
GO:0007026	negative regulation of microtubule depolymerization	biological process	IDA[11166179]; IMP[17192415]	7
GO:0051010	microtubule plus-end binding	molecular function	IDA[19632184]	5
GO:0007155	cell adhesion	biological process	NAS[8259518]	99
GO:0042483	negative regulation of odontogenesis	biological process	IEA	1
GO:0009954	proximal/distal pattern formation	biological process	IEA	5
GO:0019887	protein kinase regulator activity	molecular function	IDA[11972058]	1
GO:0007050	cell cycle arrest	biological process	IDA[8521819]	28
GO:0045667	regulation of osteoblast differentiation	biological process	IEA	3
GO:0070830	tight junction assembly	biological process	NAS[18502210]	4
GO:0006461	protein complex assembly	biological process	IDA[16188939]	32
GO:0032587	ruffle membrane	cellular component	IDA[19151759]	12
GO:0000281	cytokinesis after mitosis	biological process	IMP[17570218]	4
GO:0045295	gamma-catenin binding	molecular function	IPI[7890674]	6
GO:0060070	canonical Wnt receptor signaling pathway	biological process	IC[9601641]; NAS[11035805]	16
GO:0043065	positive regulation of apoptotic process	biological process	IMP[17227893]	38
GO:0005813	centrosome	cellular component	IDA[11283619]	78
GO:0009952	anterior/posterior pattern specification	biological process	IEA	26
GO:0001942	hair follicle development	biological process	IEA	4
GO:0001822	kidney development	biological process	IEA	17
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI	1015
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	biological process	TAS	9
GO:0016477	cell migration	biological process	IMP[19151759]	25
GO:0035019	somatic stem cell maintenance	biological process	IEA	7
GO:0006915	apoptotic process	biological process	TAS	127
GO:0005886	plasma membrane	cellular component	IDA; IDA[16611247]	839
GO:0005923	tight junction	cellular component	IDA[18502210]	18
GO:0043409	negative regulation of MAPK cascade	biological process	IEA	5
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	biological process	IMP[17227893]; NAS[11283619]	1
GO:0060041	retina development in camera-type eye	biological process	IEA	9
GO:0009953	dorsal/ventral pattern formation	biological process	IEA	12
GO:0043588	skin development	biological process	IEA	8
GO:0016328	lateral plasma membrane	cellular component	IDA[12072559]	10
GO:0005913	cell-cell adherens junction	cellular component	IDA[16611247]	9
GO:0008285	negative regulation of cell proliferation	biological process	IDA[8521819]	65
GO:0005881	cytoplasmic microtubule	cellular component	IEA	9
GO:0005634	nucleus	cellular component	IDA[12072559]	877
GO:0007091	mitotic metaphase/anaphase transition	biological process	IEA	4
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0030027	lamellipodium	cellular component	IDA[19151759]	29
GO:0045670	regulation of osteoclast differentiation	biological process	IEA	2
GO:0045785	positive regulation of cell adhesion	biological process	IEA	7
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	biological process	IDA[8521819]	7
GO:0048538	thymus development	biological process	IEA	15

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa05217	Basal cell carcinoma	9
hsa05210	Colorectal cancer	13
hsa04810	Regulation of actin cytoskeleton	49
hsa04310	Wnt signaling pathway	25
hsa05213	Endometrial cancer	14

Genes shared at least 5 GO terms with APC (count: 164)

Gene Symbol	Pathway Count	Pathway List
GSK3B	15	regulation of microtubule-based process; negative regulation of canonical Wnt receptor signaling pathway; beta-catenin destruction complex; cytosol; beta-catenin binding; positive regulation of protein catabolic process; negative regulation of apoptotic process; protein kinase binding; canonical Wnt receptor signaling pathway; centrosome; protein binding; cell migration; plasma membrane; nucleus; cytoplasm;
AXIN1	15	negative regulation of canonical Wnt receptor signaling pathway; beta-catenin destruction complex; cytosol; beta-catenin binding; positive regulation of protein catabolic process; protein kinase binding; cytoplasmic microtubule organization; canonical Wnt receptor signaling pathway; protein binding; apoptotic process; plasma membrane; lateral plasma membrane; cytoplasmic microtubule; nucleus; cytoplasm;
MEN1	10	positive regulation of cell division; response to DNA damage stimulus; cytosol; cell cycle arrest; positive regulation of apoptotic process; protein binding; negative regulation of cell proliferation; nucleus; cytoplasm; negative regulation of cyclin-dependent protein kinase activity;
APBB1	10	response to DNA damage stimulus; axonogenesis; cell cycle arrest; positive regulation of apoptotic process; protein binding; apoptotic process; plasma membrane; nucleus; cytoplasm; lamellipodium;
STK11	10	response to DNA damage stimulus; axonogenesis; cytosol; cell cycle arrest; canonical Wnt receptor signaling pathway; negative regulation of epithelial cell proliferation involved in prostate gland development; protein binding; negative regulation of cell proliferation; nucleus; cytoplasm;
WNT11	10	negative regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; axis specification; negative regulation of apoptotic process; tight junction assembly; canonical Wnt receptor signaling pathway; positive regulation of apoptotic process; anterior/posterior pattern specification; plasma membrane; cytoplasm;
CTNND1	10	negative regulation of canonical Wnt receptor signaling pathway; cadherin binding; cytosol; cell adhesion; protein binding; plasma membrane; cell-cell adherens junction; nucleus; cytoplasm; lamellipodium;
PLK1	10	microtubule binding; kinetochore; cytosol; negative regulation of apoptotic process; protein kinase binding; centrosome; protein binding; nucleus; mitotic metaphase/anaphase transition; negative regulation of cyclin-dependent protein kinase activity;
DNAJA3	9	T cell differentiation in thymus; cytosol; negative regulation of apoptotic process; protein kinase binding; positive regulation of apoptotic process; protein binding; negative regulation of cell proliferation; nucleus; cytoplasm;
CLASP2	9	regulation of microtubule-based process; cytosol; negative regulation of microtubule depolymerization; microtubule plus-end binding; ruffle membrane; protein binding; plasma membrane; cytoplasmic microtubule; cytoplasm;
TJP1	9	cytosol; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; plasma membrane; tight junction; cell-cell adherens junction; nucleus; cytoplasm;
TGFBR1	9	negative regulation of apoptotic process; cell cycle arrest; anterior/posterior pattern specification; kidney development; protein binding; apoptotic process; plasma membrane; tight junction; thymus development;
MAPT	8	positive regulation of microtubule polymerization; microtubule binding; cytosol; protein kinase binding; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; plasma membrane;
AATF	8	response to DNA damage stimulus; negative regulation of apoptotic process; cell adhesion; centrosome; protein binding; apoptotic process; nucleus; cytoplasm;
BARD1	8	response to DNA damage stimulus; positive regulation of protein catabolic process; negative regulation of apoptotic process; cell cycle arrest; positive regulation of apoptotic process; protein binding; nucleus; cytoplasm;
CDH2	8	negative regulation of canonical Wnt receptor signaling pathway; beta-catenin binding; cell adhesion; gamma-catenin binding; cell migration; plasma membrane; cell-cell adherens junction; lamellipodium;
ARHGEF2	8	microtubule binding; cytosol; negative regulation of apoptotic process; negative regulation of microtubule depolymerization; ruffle membrane; protein binding; apoptotic process; tight junction;
BCL2L11	8	microtubule binding; cytosol; positive regulation of apoptotic process; kidney development; protein binding; apoptotic process; plasma membrane; thymus development;
CLASP1	8	microtubule binding; kinetochore; cytosol; negative regulation of microtubule depolymerization; microtubule plus-end binding; centrosome; protein binding; cytoplasmic microtubule;
ILK	8	positive regulation of cell migration; cytosol; protein kinase binding; cell cycle arrest; protein binding; plasma membrane; cytoplasm; lamellipodium;
BCAR1	8	positive regulation of cell migration; cytosol; protein kinase binding; cell adhesion; protein binding; cell migration; plasma membrane; cytoplasm;
TNFAIP3	8	cytosol; positive regulation of protein catabolic process; negative regulation of apoptotic process; centrosome; protein binding; nucleus; cytoplasm; negative regulation of cyclin-dependent protein kinase activity;
PTPRJ	8	beta-catenin binding; protein kinase binding; ruffle membrane; gamma-catenin binding; protein binding; plasma membrane; negative regulation of cell proliferation; positive regulation of cell adhesion;
HES1	8	cell adhesion; protein complex assembly; protein binding; cell migration; somatic stem cell maintenance; nucleus; cytoplasm; thymus development;
NF2	8	ruffle membrane; protein binding; plasma membrane; negative regulation of MAPK cascade; negative regulation of cell proliferation; nucleus; cytoplasm; lamellipodium;
ADAM17	7	T cell differentiation in thymus; positive regulation of cell migration; cell adhesion; ruffle membrane; protein binding; plasma membrane; cytoplasm;
MAD1L1	7	mitotic cell cycle spindle assembly checkpoint; kinetochore; cytosol; centrosome; protein binding; nucleus; cytoplasm;
VEGFA	7	positive regulation of cell division; positive regulation of cell migration; negative regulation of apoptotic process; kidney development; protein binding; cytoplasm; positive regulation of cell adhesion;
PMAIP1	7	response to DNA damage stimulus; cytosol; positive regulation of apoptotic process; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; nucleus;
CCND1	7	response to DNA damage stimulus; cytosol; protein kinase binding; canonical Wnt receptor signaling pathway; protein binding; tight junction; nucleus;
RPS3	7	response to DNA damage stimulus; cytosol; protein kinase binding; ruffle membrane; protein binding; nucleus; cytoplasm;
MAPK1	7	response to DNA damage stimulus; positive regulation of cell migration; cytosol; protein binding; apoptotic process; nucleus; cytoplasm;
YAP1	7	response to DNA damage stimulus; cytosol; negative regulation of apoptotic process; protein binding; somatic stem cell maintenance; nucleus; cytoplasm;
DACT1	7	negative regulation of canonical Wnt receptor signaling pathway; beta-catenin destruction complex; beta-catenin binding; positive regulation of protein catabolic process; protein binding; nucleus; cytoplasm;
SNCA	7	microtubule binding; cytosol; negative regulation of apoptotic process; protein binding; plasma membrane; nucleus; cytoplasm;
CRYAB	7	microtubule binding; cytosol; negative regulation of apoptotic process; protein binding; plasma membrane; nucleus; cytoplasm;
PAFAH1B1	7	microtubule binding; kinetochore; cytosol; centrosome; protein binding; nucleus; cytoplasm;
ANK3	7	axonogenesis; cadherin binding; cytokinesis after mitosis; protein binding; plasma membrane; tight junction; lateral plasma membrane;
CTNNA2	7	axonogenesis; cadherin binding; cytosol; protein binding; cell-cell adherens junction; cytoplasm; lamellipodium;
RELA	7	cytosol; negative regulation of apoptotic process; protein kinase binding; hair follicle development; protein binding; nucleus; cytoplasm;
TSC1	7	cytosol; cell cycle arrest; kidney development; protein binding; negative regulation of cell proliferation; cytoplasm; lamellipodium;
WWOX	7	cytosol; positive regulation of apoptotic process; protein binding; apoptotic process; plasma membrane; nucleus; cytoplasm;
MAPRE1	7	cytosol; microtubule plus end; microtubule plus-end binding; centrosome; protein binding; cytoplasmic microtubule; cytoplasm;
INPPL1	7	cytosol; cell adhesion; protein binding; plasma membrane; negative regulation of cell proliferation; cytoplasm; lamellipodium;
PTPRK	7	beta-catenin binding; protein kinase binding; cell adhesion; gamma-catenin binding; protein binding; cell migration; negative regulation of cell proliferation;
TFAP4	7	negative regulation of apoptotic process; protein complex assembly; positive regulation of apoptotic process; protein binding; negative regulation of cell proliferation; nucleus; negative regulation of cyclin-dependent protein kinase activity;
PKD1	7	protein kinase binding; cell cycle arrest; kidney development; protein binding; skin development; nucleus; cytoplasm;
ATM	6	mitotic cell cycle spindle assembly checkpoint; response to DNA damage stimulus; negative regulation of apoptotic process; cell cycle arrest; positive regulation of apoptotic process; protein binding;
ARL2	6	positive regulation of microtubule polymerization; tight junction assembly; centrosome; protein binding; lateral plasma membrane; nucleus;
CAV3	6	positive regulation of microtubule polymerization; muscle cell homeostasis; cytoplasmic microtubule organization; protein binding; plasma membrane; negative regulation of MAPK cascade;
EGLN3	6	response to DNA damage stimulus; cytosol; protein binding; apoptotic process; nucleus; cytoplasm;
RAD9A	6	response to DNA damage stimulus; protein kinase binding; positive regulation of apoptotic process; protein binding; nucleus; cytoplasm;
DAB2	6	negative regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; negative regulation of apoptotic process; protein binding; apoptotic process; nucleus;
PRC1	6	microtubule binding; protein kinase binding; protein binding; plasma membrane; nucleus; cytoplasm;
CDK5RAP2	6	microtubule binding; cytosol; protein kinase binding; centrosome; protein binding; cytoplasm;
CEP57	6	microtubule binding; cytosol; centrosome; protein binding; nucleus; cytoplasm;
PIK3R1	6	positive regulation of cell migration; cytosol; negative regulation of apoptotic process; positive regulation of apoptotic process; protein binding; plasma membrane;
CORO1A	6	positive regulation of cell migration; protein binding; plasma membrane; nucleus; cytoplasm; lamellipodium;
TRIM32	6	positive regulation of cell migration; positive regulation of protein catabolic process; negative regulation of apoptotic process; protein binding; nucleus; cytoplasm;
BAIAP2	6	axonogenesis; cytosol; protein binding; plasma membrane; nucleus; cytoplasm;
KIF2C	6	kinetochore; cytosol; microtubule plus-end binding; protein binding; cytoplasmic microtubule; nucleus;
CBL	6	cytosol; negative regulation of apoptotic process; protein binding; plasma membrane; nucleus; cytoplasm;
TUBGCP2	6	cytosol; protein complex assembly; centrosome; protein binding; cytoplasmic microtubule; nucleus;
TSC2	6	cytosol; cell cycle arrest; protein binding; negative regulation of cell proliferation; nucleus; cytoplasm;
MALT1	6	cytosol; negative regulation of apoptotic process; protein binding; plasma membrane; nucleus; cytoplasm;
GSTP1	6	cytosol; negative regulation of apoptotic process; protein binding; negative regulation of MAPK cascade; nucleus; cytoplasm;
PAK1	6	cytosol; protein kinase binding; protein binding; apoptotic process; plasma membrane; cytoplasm;
DAXX	6	cytosol; cytokinesis after mitosis; protein binding; apoptotic process; nucleus; cytoplasm;
WASL	6	cytosol; protein complex assembly; protein binding; plasma membrane; nucleus; lamellipodium;
DSG1	6	cytosol; gamma-catenin binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; plasma membrane; lateral plasma membrane;
BIRC2	6	cytosol; negative regulation of apoptotic process; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; nucleus;
AKAP7	6	cytosol; protein kinase binding; protein binding; plasma membrane; lateral plasma membrane; nucleus;
CUL5	6	cytosol; cell cycle arrest; protein binding; plasma membrane; negative regulation of cell proliferation; nucleus;
PRKD1	6	cytosol; protein binding; apoptotic process; plasma membrane; nucleus; cytoplasm;
NCK1	6	cytosol; protein binding; cell migration; plasma membrane; nucleus; cytoplasm;
SLC9A3R2	6	beta-catenin binding; protein complex assembly; protein binding; plasma membrane; nucleus; cytoplasm;
BCL9	6	beta-catenin binding; canonical Wnt receptor signaling pathway; protein binding; somatic stem cell maintenance; nucleus; cytoplasm;
WNT10A	6	axis specification; canonical Wnt receptor signaling pathway; anterior/posterior pattern specification; hair follicle development; plasma membrane; skin development;
FGF10	6	negative regulation of apoptotic process; somatic stem cell maintenance; plasma membrane; negative regulation of cell proliferation; nucleus; thymus development;
TFAP2B	6	negative regulation of apoptotic process; kidney development; protein binding; skin development; negative regulation of cell proliferation; nucleus;
LPXN	6	cell adhesion; protein complex assembly; protein binding; plasma membrane; nucleus; cytoplasm;
SPATA13	6	ruffle membrane; protein binding; cell migration; nucleus; cytoplasm; lamellipodium;
ZBTB16	6	positive regulation of apoptotic process; anterior/posterior pattern specification; protein binding; apoptotic process; negative regulation of cell proliferation; nucleus;
FLCN	6	positive regulation of apoptotic process; protein binding; plasma membrane; nucleus; cytoplasm; positive regulation of cell adhesion;
MAGI2	6	protein binding; plasma membrane; tight junction; negative regulation of cell proliferation; nucleus; cytoplasm;
ERBB2	5	regulation of microtubule-based process; protein binding; plasma membrane; nucleus; positive regulation of cell adhesion;
PSRC1	5	positive regulation of microtubule polymerization; microtubule binding; cytosol; protein binding; cytoplasm;
CHEK1	5	response to DNA damage stimulus; cytosol; centrosome; protein binding; nucleus;
CHD1L	5	response to DNA damage stimulus; protein binding; plasma membrane; nucleus; cytoplasm;
IRF7	5	response to DNA damage stimulus; cytosol; protein binding; nucleus; cytoplasm;
ALKBH8	5	response to DNA damage stimulus; cytosol; protein binding; nucleus; cytoplasm;
BRE	5	response to DNA damage stimulus; protein binding; apoptotic process; nucleus; cytoplasm;
TAOK2	5	response to DNA damage stimulus; cell migration; apoptotic process; nucleus; cytoplasm;
MAPK3	5	response to DNA damage stimulus; cytosol; protein binding; apoptotic process; nucleus;
LATS2	5	negative regulation of canonical Wnt receptor signaling pathway; cytosol; protein binding; nucleus; negative regulation of cyclin-dependent protein kinase activity;
LATS1	5	negative regulation of canonical Wnt receptor signaling pathway; cytosol; protein kinase binding; protein binding; negative regulation of cyclin-dependent protein kinase activity;
INVS	5	negative regulation of canonical Wnt receptor signaling pathway; kidney development; protein binding; nucleus; cytoplasm;
DAB2IP	5	negative regulation of canonical Wnt receptor signaling pathway; protein kinase binding; positive regulation of apoptotic process; plasma membrane; cytoplasm;
UXT	5	microtubule binding; centrosome; protein binding; nucleus; cytoplasm;
KATNB1	5	microtubule binding; negative regulation of microtubule depolymerization; centrosome; plasma membrane; cytoplasm;
HOOK3	5	microtubule binding; cytoplasmic microtubule organization; centrosome; protein binding; cytoplasm;
KIF23	5	microtubule binding; cytosol; centrosome; protein binding; nucleus;
NDE1	5	microtubule binding; kinetochore; cytosol; centrosome; protein binding;
CCDC88A	5	microtubule binding; cytosol; cell migration; plasma membrane; lamellipodium;
MAP1S	5	microtubule binding; cytosol; protein binding; apoptotic process; nucleus;
TPPP	5	microtubule binding; protein binding; plasma membrane; nucleus; cytoplasm;
PTTG1	5	chromosome organization; cytosol; protein binding; nucleus; cytoplasm;
SEMA4D	5	positive regulation of cell migration; negative regulation of apoptotic process; cell adhesion; protein binding; plasma membrane;
VIL1	5	positive regulation of cell migration; protein complex assembly; protein binding; cytoplasm; lamellipodium;
ADRA2A	5	positive regulation of cell migration; protein kinase binding; protein binding; plasma membrane; cytoplasm;
CDH13	5	positive regulation of cell migration; cadherin binding; plasma membrane; negative regulation of cell proliferation; cytoplasm;
LLGL1	5	axonogenesis; protein kinase binding; protein complex assembly; protein binding; cytoplasm;
DRD2	5	axonogenesis; protein binding; plasma membrane; lateral plasma membrane; negative regulation of cell proliferation;
SMC1A	5	kinetochore; protein binding; nucleus; mitotic metaphase/anaphase transition; cytoplasm;
ZW10	5	kinetochore; cytosol; protein complex assembly; protein binding; nucleus;
FANCC	5	cytosol; protein complex assembly; protein binding; nucleus; cytoplasm;
PDCD4	5	cytosol; protein binding; apoptotic process; nucleus; cytoplasm;
FOSL1	5	cytosol; positive regulation of apoptotic process; protein binding; negative regulation of cell proliferation; nucleus;
GZMB	5	cytosol; protein binding; apoptotic process; nucleus; cytoplasm;
AIP	5	cytosol; protein binding; plasma membrane; nucleus; cytoplasm;
PIK3CG	5	cytosol; negative regulation of apoptotic process; protein binding; plasma membrane; cytoplasm;
GSN	5	cytosol; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; lamellipodium;
STXBP3	5	cytosol; protein binding; plasma membrane; nucleus; cytoplasm;
ROCK2	5	cytosol; centrosome; protein binding; plasma membrane; nucleus;
PARN	5	cytosol; protein kinase binding; protein binding; nucleus; cytoplasm;
ARRB1	5	cytosol; protein binding; plasma membrane; nucleus; cytoplasm;
SART1	5	cytosol; cell cycle arrest; protein binding; nucleus; cytoplasm;
NCK2	5	cytosol; protein binding; cell migration; negative regulation of cell proliferation; cytoplasm;
PDCD10	5	cytosol; negative regulation of apoptotic process; protein binding; apoptotic process; plasma membrane;
HMGA1	5	cytosol; protein complex assembly; protein binding; negative regulation of cell proliferation; nucleus;
PRKAA1	5	cytosol; negative regulation of apoptotic process; cell cycle arrest; protein binding; nucleus;
MAPK7	5	cytosol; negative regulation of apoptotic process; protein binding; apoptotic process; nucleus;
MGRN1	5	cytosol; protein binding; plasma membrane; nucleus; cytoplasm;
ARRB2	5	cytosol; protein binding; plasma membrane; nucleus; cytoplasm;
PDE2A	5	cytosol; protein binding; plasma membrane; nucleus; cytoplasm;
PYCARD	5	cytosol; positive regulation of apoptotic process; protein binding; nucleus; cytoplasm;
SOCS1	5	cytosol; protein kinase binding; protein binding; nucleus; cytoplasm;
RPTOR	5	cytosol; protein kinase binding; cell cycle arrest; protein binding; cytoplasm;
AMOTL1	5	cytosol; protein binding; tight junction; cytoplasm; lamellipodium;
BAD	5	cytosol; protein kinase binding; positive regulation of apoptotic process; protein binding; apoptotic process;
CEP164	5	cytosol; centrosome; protein binding; nucleus; cytoplasm;
PSMC3	5	cytosol; protein binding; apoptotic process; nucleus; cytoplasm;
PDPK1	5	cytosol; protein kinase binding; protein binding; plasma membrane; cytoplasm;
PARK2	5	cytosol; protein kinase binding; protein binding; nucleus; cytoplasm;
GJA1	5	positive regulation of protein catabolic process; protein binding; apoptotic process; plasma membrane; negative regulation of cell proliferation;
GATA6	5	negative regulation of apoptotic process; protein kinase binding; protein binding; apoptotic process; nucleus;
BNIP3	5	negative regulation of apoptotic process; protein binding; apoptotic process; nucleus; cytoplasm;
IL1RN	5	negative regulation of apoptotic process; centrosome; plasma membrane; nucleus; cytoplasm;
FLT4	5	negative regulation of apoptotic process; protein binding; plasma membrane; nucleus; cytoplasm;
BIRC3	5	negative regulation of apoptotic process; protein binding; apoptotic process; nucleus; cytoplasm;
HNF1B	5	negative regulation of apoptotic process; anterior/posterior pattern specification; kidney development; protein binding; nucleus;
CFL1	5	negative regulation of apoptotic process; ruffle membrane; protein binding; nucleus; cytoplasm;
NEK6	5	protein kinase binding; protein binding; apoptotic process; nucleus; cytoplasm;
PERP	5	cell adhesion; apoptotic process; plasma membrane; nucleus; cytoplasm;
FEZ1	5	cell adhesion; centrosome; protein binding; plasma membrane; cytoplasm;
PVRL1	5	cell adhesion; protein binding; plasma membrane; retina development in camera-type eye; cell-cell adherens junction;
ACHE	5	cell adhesion; protein binding; plasma membrane; retina development in camera-type eye; nucleus;
ARVCF	5	cell adhesion; protein binding; plasma membrane; nucleus; cytoplasm;
HOXA9	5	proximal/distal pattern formation; anterior/posterior pattern specification; protein binding; nucleus; cytoplasm;
IL12B	5	cell cycle arrest; protein binding; cell migration; cytoplasm; positive regulation of cell adhesion;
HOXA5	5	positive regulation of apoptotic process; anterior/posterior pattern specification; protein binding; cell migration; nucleus;
PPP4C	5	centrosome; protein binding; plasma membrane; nucleus; cytoplasm;
ADRB1	5	protein binding; apoptotic process; plasma membrane; nucleus; cytoplasm;
FRK	5	protein binding; plasma membrane; negative regulation of cell proliferation; nucleus; cytoplasm;

Genes shared at least 2 KEGG pathways with APC (count: 14)

Gene Symbol	Pathway Count	Pathway List
GSK3B	4	Basal cell carcinoma; Colorectal cancer; Wnt signaling pathway; Endometrial cancer;
AXIN1	4	Basal cell carcinoma; Colorectal cancer; Wnt signaling pathway; Endometrial cancer;
FZD4	3	Basal cell carcinoma; Colorectal cancer; Wnt signaling pathway;
MAPK3	3	Colorectal cancer; Regulation of actin cytoskeleton; Endometrial cancer;
PIK3CG	3	Colorectal cancer; Regulation of actin cytoskeleton; Endometrial cancer;
MAPK1	3	Colorectal cancer; Regulation of actin cytoskeleton; Endometrial cancer;
PIK3R1	3	Colorectal cancer; Regulation of actin cytoskeleton; Endometrial cancer;
CCND1	3	Colorectal cancer; Wnt signaling pathway; Endometrial cancer;
WNT11	2	Basal cell carcinoma; Wnt signaling pathway;
WNT6	2	Basal cell carcinoma; Wnt signaling pathway;
WNT10A	2	Basal cell carcinoma; Wnt signaling pathway;
BAD	2	Colorectal cancer; Endometrial cancer;
MAPK9	2	Colorectal cancer; Wnt signaling pathway;
ROCK2	2	Regulation of actin cytoskeleton; Wnt signaling pathway;

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Region: chr5:112043195..112181936 View in gBrowse