ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DAB2
Symbol Alias	DOC-2
Approved Name	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Previous Name	disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein)
Location	5p13
Position	chr5:39371780-39462402, -
External Links	HGNC: 2662 Entrez Gene: 1601 Ensembl: ENSG00000153071 UCSC: uc003jlx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 48)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 48)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IMP[12805222]	64
GO:0045807	positive regulation of endocytosis	Biological Process		6
GO:0046332	SMAD binding	Molecular Function	IDA[11387212]	5
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IMP[12805222]	80
GO:0035615	clathrin adaptor activity	Molecular Function	IMP[16984970]	1
GO:0035612	AP-2 adaptor complex binding	Molecular Function		1
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[15734730]	77
GO:0038024	cargo receptor activity	Molecular Function	IMP[16984970]	1
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process	IMP[12805222]	14
GO:0071560	cellular response to transforming growth factor beta stimulus	Biological Process		9
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	Biological Process	IMP[12805222]	1
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Biological Process		2
GO:0060391	positive regulation of SMAD protein import into nucleus	Biological Process	IDA[11387212]	2
GO:0048268	clathrin coat assembly	Biological Process		3
GO:0070022	transforming growth factor beta receptor homodimeric complex	Cellular Component	IDA[11387212]	2
GO:0060766	negative regulation of androgen receptor signaling pathway	Biological Process	IMP[16267015]	2
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Biological Process	IDA[11387212]	3
GO:0015031	protein transport	Biological Process		75
GO:0016055	Wnt receptor signaling pathway	Biological Process		20
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0007588	excretion	Biological Process		10
GO:0008022	protein C-terminus binding	Molecular Function	IPI[15837803]	32
GO:0008283	cell proliferation	Biological Process	TAS[9620555]	60
GO:0010718	positive regulation of epithelial to mesenchymal transition	Biological Process	IDA[15734730]	3
GO:0030665	clathrin-coated vesicle membrane	Cellular Component		3
GO:0032091	negative regulation of protein binding	Biological Process	IMP[12805222]	4
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IMP[12805222]	5
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	Biological Process		2
GO:0030099	myeloid cell differentiation	Biological Process		5
GO:0030132	clathrin coat of coated pit	Cellular Component		3
GO:0030335	positive regulation of cell migration	Biological Process		29
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IDA[11387212]	6
GO:0005634	nucleus	Cellular Component		770
GO:0005905	coated pit	Cellular Component	IDA[12857860]	8
GO:0005515	protein binding	Molecular Function	IPI[12805222]	910
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Molecular Function		4
GO:0007257	activation of JUN kinase activity	Biological Process		8
GO:0007492	endoderm development	Biological Process		3
GO:0006907	pinocytosis	Biological Process		1
GO:0006915	apoptotic process	Biological Process		111
GO:0000904	cell morphogenesis involved in differentiation	Biological Process		1
GO:0001934	positive regulation of protein phosphorylation	Biological Process	IMP[12805222]	22
GO:0005178	integrin binding	Molecular Function		15
GO:0001701	in utero embryonic development	Biological Process		32
GO:0001921	positive regulation of receptor recycling	Biological Process		2
GO:2001046	positive regulation of integrin-mediated signaling pathway	Biological Process		1
GO:2000370	positive regulation of clathrin-mediated endocytosis	Biological Process	IMP[16984970]	2
GO:2000643	positive regulation of early endosome to late endosome transport	Biological Process		2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...

Genes shared at least 5 GO terms with DAB2 (count: 26)

Gene Symbol	Pathway Count	Pathway List
TGFBR1	10	SMAD binding; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; cellular response to transforming growth factor beta stimulus; positive regulation of SMAD protein import into nucleus; transforming growth factor beta receptor homodimeric complex; positive regulation of pathway-restricted SMAD protein phosphorylation; protein binding; apoptotic process; in utero embryonic development;
GSK3B	7	negative regulation of transcription, DNA-dependent; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of protein binding; nucleus; protein binding; integrin binding;
KDM1A	7	negative regulation of transcription, DNA-dependent; negative regulation of apoptotic process; cell proliferation; negative regulation of protein binding; nucleus; protein binding; in utero embryonic development;
GATA6	6	negative regulation of transcription, DNA-dependent; negative regulation of apoptotic process; nucleus; protein binding; apoptotic process; in utero embryonic development;
TFAP2A	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; positive regulation of cell migration; nucleus; protein binding;
WNT11	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; endoderm development;
XRCC5	6	negative regulation of transcription, DNA-dependent; negative regulation of apoptotic process; protein C-terminus binding; cell proliferation; nucleus; protein binding;
ZBTB16	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; nucleus; protein binding; apoptotic process;
PICALM	6	positive regulation of transcription, DNA-dependent; clathrin coat assembly; clathrin coat of coated pit; nucleus; coated pit; protein binding;
APC	6	negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; nucleus; protein binding; apoptotic process;
PRKAA1	6	negative regulation of apoptotic process; Wnt receptor signaling pathway; apical plasma membrane; protein C-terminus binding; nucleus; protein binding;
ADAM17	6	apical plasma membrane; positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; protein binding; positive regulation of protein phosphorylation; integrin binding;
ERBB2	6	apical plasma membrane; protein C-terminus binding; cell proliferation; nucleus; protein binding; positive regulation of protein phosphorylation;
DAXX	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; activation of JUN kinase activity; apoptotic process;
HINFP	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nucleus; protein binding; in utero embryonic development;
RELA	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; nucleus; protein binding;
SNW1	5	negative regulation of transcription, DNA-dependent; SMAD binding; positive regulation of transforming growth factor beta receptor signaling pathway; nucleus; protein binding;
SNCA	5	positive regulation of endocytosis; negative regulation of apoptotic process; nucleus; protein binding; positive regulation of receptor recycling;
ILK	5	positive regulation of transcription, DNA-dependent; cell proliferation; positive regulation of cell migration; protein binding; integrin binding;
MAPK1	5	positive regulation of transcription, DNA-dependent; positive regulation of cell migration; nucleus; protein binding; apoptotic process;
TGFB1I1	5	positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; positive regulation of transforming growth factor beta receptor signaling pathway; protein binding;
MAPK7	5	negative regulation of apoptotic process; cellular response to transforming growth factor beta stimulus; nucleus; protein binding; apoptotic process;
PLK1	5	negative regulation of apoptotic process; cell proliferation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleus; protein binding;
VEGFA	5	negative regulation of apoptotic process; positive regulation of cell migration; protein binding; positive regulation of protein phosphorylation; in utero embryonic development;
WWOX	5	cellular response to transforming growth factor beta stimulus; Wnt receptor signaling pathway; nucleus; protein binding; apoptotic process;
FLCN	5	positive regulation of transforming growth factor beta receptor signaling pathway; nucleus; protein binding; positive regulation of protein phosphorylation; in utero embryonic development;

Genes shared at least 2 KEGG pathways with DAB2 (count: 0)

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Region: chr5:39371780..39462402 View in gBrowse