ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	WNT11
Approved Name	wingless-type MMTV integration site family, member 11
Location	11q13.5
Position	chr11:75897369-75921780, -1
External Links	HGNC: 12776 Entrez Gene: 7481 Ensembl: ENSG00000085741 UCSC: uc001oxe.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 49)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 49)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005615	extracellular space	cellular component	IBA	133
GO:0032320	positive regulation of Ras GTPase activity	biological process	IMP	5
GO:0060197	cloacal septation	biological process	IEP[9757009]	1
GO:0009798	axis specification	biological process	IBA	4
GO:0005099	Ras GTPase activator activity	molecular function	IMP	5
GO:0034394	protein localization to cell surface	biological process	IMP	4
GO:0060021	palate development	biological process	IMP[18413325]	4
GO:0009952	anterior/posterior pattern specification	biological process	IBA	26
GO:0030282	bone mineralization	biological process	IBA	5
GO:0030336	negative regulation of cell migration	biological process	IMP	13
GO:0001649	osteoblast differentiation	biological process	IBA	10
GO:0090037	positive regulation of protein kinase C signaling cascade	biological process	IMP	6
GO:0005886	plasma membrane	cellular component	IBA	839
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	biological process	IMP	16
GO:0043065	positive regulation of apoptotic process	biological process	IEA	38
GO:0072201	negative regulation of mesenchymal cell proliferation	biological process	IEA	1
GO:0051496	positive regulation of stress fiber assembly	biological process	IMP	7
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0032915	positive regulation of transforming growth factor beta2 production	biological process	IBA	1
GO:0001664	G-protein coupled receptor binding	molecular function	IBA	9
GO:0030308	negative regulation of cell growth	biological process	IMP	23
GO:0090272	negative regulation of fibroblast growth factor production	biological process	IEA	1
GO:0061037	negative regulation of cartilage development	biological process	NAS[9757009]	1
GO:0030295	protein kinase activator activity	molecular function	IMP	3
GO:0071300	cellular response to retinoic acid	biological process	ISS	8
GO:0060412	ventricular septum morphogenesis	biological process	IBA	5
GO:0035567	non-canonical Wnt receptor signaling pathway	biological process	IEA	1
GO:0030325	adrenal gland development	biological process	IEP[9757009]	4
GO:0060070	canonical Wnt receptor signaling pathway	biological process	IEA	16
GO:0007492	endoderm development	biological process	IBA	3
GO:0072177	mesonephric duct development	biological process	IEP[9757009]	3
GO:0010628	positive regulation of gene expression	biological process	IMP	29
GO:0003151	outflow tract morphogenesis	biological process	IBA	11
GO:0060484	lung-associated mesenchyme development	biological process	IEP[9757009]	3
GO:0070830	tight junction assembly	biological process	IBA	4
GO:0048844	artery morphogenesis	biological process	IBA	9
GO:0060548	negative regulation of cell death	biological process	IMP	5
GO:0043066	negative regulation of apoptotic process	biological process	IMP	85
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IMP	77
GO:0061101	neuroendocrine cell differentiation	biological process	IMP	1
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IMP[19847889]	89
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[19847889]	28
GO:0030335	positive regulation of cell migration	biological process	IMP	28
GO:0048706	embryonic skeletal system development	biological process	IEP[9757009]	4
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	51
GO:0060675	ureteric bud morphogenesis	biological process	IEP[9757009]	2
GO:0030182	neuron differentiation	biological process	ISS	10
GO:0006468	protein phosphorylation	biological process	IMP	58
GO:0045860	positive regulation of protein kinase activity	biological process	IMP	8

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa05217	Basal cell carcinoma	9
hsa04916	Melanogenesis	18
hsa04310	Wnt signaling pathway	25
hsa04340	Hedgehog signaling pathway	8

Genes shared at least 5 GO terms with WNT11 (count: 24)

Gene Symbol	Pathway Count	Pathway List
WNT6	11	extracellular space; axis specification; anterior/posterior pattern specification; plasma membrane; G-protein coupled receptor binding; cellular response to retinoic acid; canonical Wnt receptor signaling pathway; positive regulation of gene expression; positive regulation of transcription, DNA-dependent; proteinaceous extracellular matrix; neuron differentiation;
APC	10	axis specification; anterior/posterior pattern specification; plasma membrane; negative regulation of canonical Wnt receptor signaling pathway; positive regulation of apoptotic process; cytoplasm; canonical Wnt receptor signaling pathway; tight junction assembly; negative regulation of apoptotic process; positive regulation of cell migration;
VEGFA	9	extracellular space; positive regulation of protein kinase C signaling cascade; cytoplasm; positive regulation of gene expression; outflow tract morphogenesis; artery morphogenesis; negative regulation of apoptotic process; positive regulation of cell migration; proteinaceous extracellular matrix;
WNT10A	8	extracellular space; axis specification; anterior/posterior pattern specification; plasma membrane; G-protein coupled receptor binding; canonical Wnt receptor signaling pathway; positive regulation of gene expression; proteinaceous extracellular matrix;
TGFBR1	7	palate development; anterior/posterior pattern specification; plasma membrane; artery morphogenesis; negative regulation of apoptotic process; positive regulation of transcription, DNA-dependent; protein phosphorylation;
GSK3B	7	plasma membrane; negative regulation of canonical Wnt receptor signaling pathway; cytoplasm; canonical Wnt receptor signaling pathway; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; protein phosphorylation;
FGF9	6	extracellular space; osteoblast differentiation; cytoplasm; positive regulation of gene expression; lung-associated mesenchyme development; embryonic skeletal system development;
DAB2IP	6	positive regulation of Ras GTPase activity; Ras GTPase activator activity; plasma membrane; negative regulation of canonical Wnt receptor signaling pathway; positive regulation of apoptotic process; cytoplasm;
FLCN	6	negative regulation of cell migration; plasma membrane; positive regulation of apoptotic process; cytoplasm; negative regulation of cell growth; positive regulation of gene expression;
FZD4	6	plasma membrane; cytoplasm; cellular response to retinoic acid; canonical Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent; neuron differentiation;
DAB2	6	negative regulation of canonical Wnt receptor signaling pathway; endoderm development; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of cell migration;
STK11	6	cytoplasm; negative regulation of cell growth; protein kinase activator activity; canonical Wnt receptor signaling pathway; protein phosphorylation; positive regulation of protein kinase activity;
HES1	6	cytoplasm; ventricular septum morphogenesis; outflow tract morphogenesis; artery morphogenesis; negative regulation of transcription, DNA-dependent; ureteric bud morphogenesis;
CTGF	5	extracellular space; plasma membrane; positive regulation of stress fiber assembly; positive regulation of gene expression; proteinaceous extracellular matrix;
FGF10	5	extracellular space; protein localization to cell surface; plasma membrane; negative regulation of apoptotic process; positive regulation of transcription, DNA-dependent;
MEN1	5	palate development; positive regulation of apoptotic process; cytoplasm; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
TBX1	5	anterior/posterior pattern specification; cellular response to retinoic acid; outflow tract morphogenesis; artery morphogenesis; positive regulation of transcription, DNA-dependent;
SOX8	5	osteoblast differentiation; cytoplasm; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
PIK3R1	5	plasma membrane; positive regulation of apoptotic process; negative regulation of apoptotic process; positive regulation of cell migration; protein phosphorylation;
AXIN1	5	plasma membrane; negative regulation of canonical Wnt receptor signaling pathway; cytoplasm; canonical Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent;
APBB1	5	plasma membrane; positive regulation of apoptotic process; cytoplasm; negative regulation of cell growth; positive regulation of transcription, DNA-dependent;
ILK	5	plasma membrane; cytoplasm; positive regulation of transcription, DNA-dependent; positive regulation of cell migration; protein phosphorylation;
TFAP4	5	positive regulation of apoptotic process; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
RELA	5	cytoplasm; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;

Genes shared at least 2 KEGG pathways with WNT11 (count: 13)

Gene Symbol	Pathway Count	Pathway List
GSK3B	4	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway; Hedgehog signaling pathway;
WNT6	4	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway; Hedgehog signaling pathway;
WNT10A	4	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway; Hedgehog signaling pathway;
FZD4	3	Basal cell carcinoma; Melanogenesis; Wnt signaling pathway;
STK36	2	Basal cell carcinoma; Hedgehog signaling pathway;
PTCH1	2	Basal cell carcinoma; Hedgehog signaling pathway;
APC	2	Basal cell carcinoma; Wnt signaling pathway;
AXIN1	2	Basal cell carcinoma; Wnt signaling pathway;
CAMK2D	2	Melanogenesis; Wnt signaling pathway;
PLCB3	2	Melanogenesis; Wnt signaling pathway;
PLCB2	2	Melanogenesis; Wnt signaling pathway;
CREBBP	2	Melanogenesis; Wnt signaling pathway;
CSNK1E	2	Wnt signaling pathway; Hedgehog signaling pathway;

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Region: chr11:75897369..75921780 View in gBrowse