ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CTGF
Symbol Alias	IGFBP8, CCN2
Approved Name	connective tissue growth factor
Location	6q23.2
Position	chr6:132269316-132272518, -
External Links	HGNC: 2500 Entrez Gene: 1490 Ensembl: ENSG00000118523 UCSC: uc003qcz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 60)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 60)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051385	response to mineralocorticoid stimulus	Biological Process		2
GO:0050867	positive regulation of cell activation	Biological Process		1
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0046330	positive regulation of JNK cascade	Biological Process		12
GO:0070278	extracellular matrix constituent secretion	Biological Process		1
GO:0060452	positive regulation of cardiac muscle contraction	Biological Process		2
GO:0060401	cytosolic calcium ion transport	Biological Process		1
GO:0051496	positive regulation of stress fiber assembly	Biological Process		7
GO:0072593	reactive oxygen species metabolic process	Biological Process		7
GO:0070542	response to fatty acid	Biological Process		3
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process		22
GO:0070318	positive regulation of G0 to G1 transition	Biological Process		2
GO:0030324	lung development	Biological Process		12
GO:0032330	regulation of chondrocyte differentiation	Biological Process		3
GO:0016477	cell migration	Biological Process		24
GO:0030154	cell differentiation	Biological Process		51
GO:0034059	response to anoxia	Biological Process		2
GO:0035556	intracellular signal transduction	Biological Process		44
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0032967	positive regulation of collagen biosynthetic process	Biological Process		4
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process		7
GO:0035988	chondrocyte proliferation	Biological Process		2
GO:0043200	response to amino acid stimulus	Biological Process		7
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0045597	positive regulation of cell differentiation	Biological Process		4
GO:0043434	response to peptide hormone stimulus	Biological Process		9
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0006260	DNA replication	Biological Process		27
GO:0007229	integrin-mediated signaling pathway	Biological Process		10
GO:0007160	cell-matrix adhesion	Biological Process		13
GO:0008201	heparin binding	Molecular Function		26
GO:0008083	growth factor activity	Molecular Function		25
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process		26
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0009611	response to wounding	Biological Process	TAS[10809757]	9
GO:0008544	epidermis development	Biological Process	TAS[10809757]	12
GO:0010260	organ senescence	Biological Process		1
GO:0009749	response to glucose stimulus	Biological Process		10
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0010467	gene expression	Biological Process		140
GO:0010942	positive regulation of cell death	Biological Process		3
GO:0010629	negative regulation of gene expression	Biological Process		13
GO:0001502	cartilage condensation	Biological Process		5
GO:0001503	ossification	Biological Process		9
GO:0001525	angiogenesis	Biological Process		35
GO:0001558	regulation of cell growth	Biological Process		11
GO:0001934	positive regulation of protein phosphorylation	Biological Process		22
GO:0001968	fibronectin binding	Molecular Function		3
GO:0005178	integrin binding	Molecular Function		15
GO:0005520	insulin-like growth factor binding	Molecular Function		1
GO:0005576	extracellular region	Cellular Component		240
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005615	extracellular space	Cellular Component		126
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005801	cis-Golgi network	Cellular Component		14
GO:0005829	cytosol	Cellular Component		447
GO:0005886	plasma membrane	Cellular Component	TAS[10809757]	772
GO:0005938	cell cortex	Cellular Component		26

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CTGF (count: 52)

Gene Symbol	Pathway Count	Pathway List
VEGFA	11	lung development; heparin binding; growth factor activity; positive regulation of cell proliferation; positive regulation of gene expression; angiogenesis; positive regulation of protein phosphorylation; fibronectin binding; extracellular region; proteinaceous extracellular matrix; extracellular space;
FGF10	9	positive regulation of ERK1 and ERK2 cascade; response to estradiol stimulus; heparin binding; growth factor activity; fibroblast growth factor receptor signaling pathway; angiogenesis; extracellular region; extracellular space; plasma membrane;
FGF4	9	positive regulation of ERK1 and ERK2 cascade; heparin binding; growth factor activity; fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation; cartilage condensation; positive regulation of protein phosphorylation; extracellular region; cytosol;
ACHE	8	perinuclear region of cytoplasm; small molecule metabolic process; DNA replication; response to wounding; extracellular region; extracellular space; Golgi apparatus; plasma membrane;
MED1	8	positive regulation of G0 to G1 transition; small molecule metabolic process; cellular lipid metabolic process; transcription initiation from RNA polymerase II promoter; DNA replication; positive regulation of gene expression; gene expression; angiogenesis;
FGF9	8	heparin binding; growth factor activity; fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of gene expression; angiogenesis; extracellular region; extracellular space;
GSK3B	7	perinuclear region of cytoplasm; cell migration; intracellular signal transduction; fibroblast growth factor receptor signaling pathway; integrin binding; cytosol; plasma membrane;
VEGFB	7	positive regulation of ERK1 and ERK2 cascade; heparin binding; growth factor activity; negative regulation of gene expression; angiogenesis; extracellular region; extracellular space;
IL18	7	lung development; positive regulation of collagen biosynthetic process; positive regulation of gene expression; angiogenesis; extracellular region; extracellular space; cytosol;
FN1	7	cell migration; heparin binding; response to wounding; angiogenesis; extracellular region; proteinaceous extracellular matrix; extracellular space;
PRKD1	7	small molecule metabolic process; integrin-mediated signaling pathway; angiogenesis; Golgi apparatus; cytosol; plasma membrane; cell cortex;
PLA2G5	6	perinuclear region of cytoplasm; small molecule metabolic process; heparin binding; extracellular region; Golgi apparatus; plasma membrane;
PRKAR2B	6	perinuclear region of cytoplasm; intracellular signal transduction; small molecule metabolic process; fibroblast growth factor receptor signaling pathway; cytosol; plasma membrane;
PTCH1	6	perinuclear region of cytoplasm; intracellular membrane-bounded organelle; heparin binding; epidermis development; Golgi apparatus; plasma membrane;
SNCA	6	perinuclear region of cytoplasm; extracellular region; Golgi apparatus; cytosol; plasma membrane; cell cortex;
FGF19	6	positive regulation of JNK cascade; positive regulation of ERK1 and ERK2 cascade; growth factor activity; fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation; extracellular region;
FLT4	6	positive regulation of JNK cascade; positive regulation of ERK1 and ERK2 cascade; positive regulation of cell proliferation; positive regulation of protein phosphorylation; extracellular region; plasma membrane;
IL6	6	positive regulation of ERK1 and ERK2 cascade; response to amino acid stimulus; growth factor activity; positive regulation of cell proliferation; extracellular region; extracellular space;
MAPK3	6	positive regulation of ERK1 and ERK2 cascade; fibroblast growth factor receptor signaling pathway; gene expression; positive regulation of protein phosphorylation; Golgi apparatus; cytosol;
BAD	6	response to estradiol stimulus; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to amino acid stimulus; fibroblast growth factor receptor signaling pathway; response to glucose stimulus; cytosol;
EREG	6	response to peptide hormone stimulus; growth factor activity; positive regulation of cell proliferation; angiogenesis; extracellular region; extracellular space;
ILK	6	integrin-mediated signaling pathway; cell-matrix adhesion; positive regulation of cell proliferation; integrin binding; cytosol; plasma membrane;
IGF2	6	growth factor activity; positive regulation of cell proliferation; ossification; positive regulation of protein phosphorylation; extracellular region; extracellular space;
PPM1F	5	perinuclear region of cytoplasm; positive regulation of stress fiber assembly; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of gene expression; cytosol;
PYCARD	5	positive regulation of JNK cascade; positive regulation of ERK1 and ERK2 cascade; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; extracellular region; cytosol;
WNT11	5	positive regulation of stress fiber assembly; positive regulation of gene expression; proteinaceous extracellular matrix; extracellular space; plasma membrane;
ARG1	5	lung development; response to amino acid stimulus; small molecule metabolic process; extracellular space; cytosol;
BCAR1	5	cell migration; integrin-mediated signaling pathway; regulation of cell growth; cytosol; plasma membrane;
CCDC88A	5	cell migration; DNA replication; Golgi apparatus; cytosol; plasma membrane;
GPC6	5	cell migration; small molecule metabolic process; proteinaceous extracellular matrix; extracellular space; plasma membrane;
TNN	5	cell migration; cell-matrix adhesion; integrin binding; proteinaceous extracellular matrix; extracellular space;
CRYAB	5	response to estradiol stimulus; negative regulation of gene expression; Golgi apparatus; cytosol; plasma membrane;
GHR	5	response to estradiol stimulus; positive regulation of cell differentiation; extracellular region; extracellular space; plasma membrane;
IHH	5	positive regulation of collagen biosynthetic process; chondrocyte proliferation; extracellular region; extracellular space; plasma membrane;
NCOA6	5	intracellular membrane-bounded organelle; small molecule metabolic process; cellular lipid metabolic process; transcription initiation from RNA polymerase II promoter; DNA replication;
STS	5	intracellular membrane-bounded organelle; small molecule metabolic process; epidermis development; Golgi apparatus; plasma membrane;
APOA1	5	small molecule metabolic process; cellular lipid metabolic process; extracellular region; extracellular space; plasma membrane;
APOA5	5	small molecule metabolic process; cellular lipid metabolic process; heparin binding; extracellular region; extracellular space;
INPPL1	5	small molecule metabolic process; negative regulation of gene expression; Golgi apparatus; cytosol; plasma membrane;
INS	5	small molecule metabolic process; positive regulation of cell differentiation; positive regulation of cell proliferation; extracellular region; extracellular space;
LPL	5	small molecule metabolic process; heparin binding; extracellular region; extracellular space; plasma membrane;
OGN	5	small molecule metabolic process; growth factor activity; extracellular region; proteinaceous extracellular matrix; extracellular space;
EIF2B1	5	response to peptide hormone stimulus; response to glucose stimulus; gene expression; cytosol; plasma membrane;
NGF	5	response to peptide hormone stimulus; growth factor activity; positive regulation of gene expression; extracellular region; extracellular space;
UBB	5	transcription initiation from RNA polymerase II promoter; fibroblast growth factor receptor signaling pathway; gene expression; cytosol; plasma membrane;
UBC	5	transcription initiation from RNA polymerase II promoter; fibroblast growth factor receptor signaling pathway; gene expression; cytosol; plasma membrane;
SYK	5	integrin-mediated signaling pathway; angiogenesis; integrin binding; cytosol; plasma membrane;
JAM3	5	cell-matrix adhesion; angiogenesis; integrin binding; extracellular space; plasma membrane;
BTC	5	growth factor activity; positive regulation of cell proliferation; extracellular region; extracellular space; plasma membrane;
FGF3	5	growth factor activity; fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation; extracellular region; Golgi apparatus;
TNC	5	positive regulation of cell proliferation; response to wounding; positive regulation of gene expression; extracellular region; extracellular space;
WNT6	5	positive regulation of gene expression; extracellular region; proteinaceous extracellular matrix; extracellular space; plasma membrane;

Genes shared at least 2 KEGG pathways with CTGF (count: 0)

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Region: chr6:132269316..132272518 View in gBrowse