ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IGF2
Previous Symbol	C11orf43
Symbol Alias	FLJ44734
Approved Name	insulin-like growth factor 2 (somatomedin A)
Previous Name	chromosome 11 open reading frame 43
Location	11p15.5
Position	chr11:2150342-2170833, -
External Links	HGNC: 5466 Entrez Gene: 3481 Ensembl: ENSG00000167244 UCSC: uc009ydf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2070762	Chr11:2186335(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant	2(1/1/0)
rs3842753	Chr11:2181060(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs7924316	Chr11:2173447(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs4320932	Chr11:2171601(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005158	insulin receptor binding	Molecular Function	IPI[12138094]	6
GO:0005159	insulin-like growth factor receptor binding	Molecular Function	TAS[1845984]	5
GO:0001503	ossification	Biological Process		9
GO:0001934	positive regulation of protein phosphorylation	Biological Process		22
GO:0001501	skeletal system development	Biological Process	TAS[8298652]	16
GO:0008083	growth factor activity	Molecular Function	IDA[11500939]	25
GO:0008284	positive regulation of cell proliferation	Biological Process	IC[11500939]	69
GO:0008286	insulin receptor signaling pathway	Biological Process	TAS[1845984]	32
GO:0030546	receptor activator activity	Molecular Function		2
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade	Biological Process		1
GO:0042104	positive regulation of activated T cell proliferation	Biological Process	IDA[15694994]	6
GO:0043085	positive regulation of catalytic activity	Biological Process		7
GO:0043410	positive regulation of MAPK cascade	Biological Process	IDA[11500939]	17
GO:0005179	hormone activity	Molecular Function		7
GO:0005515	protein binding	Molecular Function	IPI[10611375]	910
GO:0005576	extracellular region	Cellular Component		240
GO:0005615	extracellular space	Cellular Component		126
GO:0006006	glucose metabolic process	Biological Process		19
GO:0006349	regulation of gene expression by genetic imprinting	Biological Process	TAS[8968759]	3
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS[12881524]	158
GO:0007275	multicellular organismal development	Biological Process	TAS[6382022]	71
GO:2000467	positive regulation of glycogen (starch) synthase activity	Biological Process		1
GO:2000273	positive regulation of receptor activity	Biological Process		3
GO:0045725	positive regulation of glycogen biosynthetic process	Biological Process		3
GO:0043539	protein serine/threonine kinase activator activity	Molecular Function		1
GO:0046628	positive regulation of insulin receptor signaling pathway	Biological Process	IDA[11500939]	2
GO:0045840	positive regulation of mitosis	Biological Process	IDA[11500939]	7
GO:0051781	positive regulation of cell division	Biological Process		11
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process		14
GO:0071902	positive regulation of protein serine/threonine kinase activity	Biological Process		4
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process	IDA[11500939]	17

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IGF2 (count: 16)

Gene Symbol	Pathway Count	Pathway List
INS	16	insulin receptor binding; insulin-like growth factor receptor binding; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of MAPK cascade; hormone activity; protein binding; extracellular region; extracellular space; glucose metabolic process; regulation of transcription, DNA-dependent; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of mitosis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade;
VEGFA	8	positive regulation of protein phosphorylation; growth factor activity; positive regulation of cell proliferation; protein binding; extracellular region; extracellular space; positive regulation of cell division; positive regulation of peptidyl-tyrosine phosphorylation;
EREG	7	growth factor activity; positive regulation of cell proliferation; protein binding; extracellular region; extracellular space; positive regulation of mitosis; positive regulation of cell division;
FGF9	7	growth factor activity; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of MAPK cascade; extracellular region; extracellular space; positive regulation of cell division;
IL6	7	growth factor activity; positive regulation of cell proliferation; positive regulation of MAPK cascade; extracellular region; extracellular space; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade;
VEGFB	7	growth factor activity; protein binding; extracellular region; extracellular space; positive regulation of cell division; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade;
CTGF	6	ossification; positive regulation of protein phosphorylation; growth factor activity; positive regulation of cell proliferation; extracellular region; extracellular space;
FGF4	6	positive regulation of protein phosphorylation; growth factor activity; positive regulation of cell proliferation; insulin receptor signaling pathway; extracellular region; positive regulation of cell division;
FGF10	6	growth factor activity; insulin receptor signaling pathway; positive regulation of MAPK cascade; extracellular region; extracellular space; positive regulation of peptidyl-tyrosine phosphorylation;
FGF3	6	growth factor activity; positive regulation of cell proliferation; insulin receptor signaling pathway; protein binding; extracellular region; positive regulation of cell division;
FLT4	5	positive regulation of protein phosphorylation; positive regulation of cell proliferation; positive regulation of MAPK cascade; protein binding; extracellular region;
INHA	5	skeletal system development; growth factor activity; hormone activity; protein binding; extracellular region;
TGFBR1	5	skeletal system development; positive regulation of cell proliferation; protein binding; regulation of transcription, DNA-dependent; positive regulation of protein kinase B signaling cascade;
BTC	5	growth factor activity; positive regulation of cell proliferation; extracellular region; extracellular space; positive regulation of cell division;
FGF19	5	growth factor activity; positive regulation of cell proliferation; insulin receptor signaling pathway; protein binding; extracellular region;
PRKAA1	5	positive regulation of cell proliferation; insulin receptor signaling pathway; protein binding; glucose metabolic process; regulation of transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with IGF2 (count: 0)

View in gBrowse

Region: chr11:2150342..2170833 View in gBrowse