ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TNN
Approved Name	tenascin N
Location	1q23-q24
Position	chr1:175036994-175117202, +
External Links	HGNC: 22942 Entrez Gene: 63923 Ensembl: ENSG00000120332 UCSC: uc001gkl.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	No. of Genes in ADHDgene
GO:0007160	cell-matrix adhesion	Biological Process	13
GO:0007165	signal transduction	Biological Process	171
GO:0005578	proteinaceous extracellular matrix	Cellular Component	47
GO:0005615	extracellular space	Cellular Component	126
GO:0005178	integrin binding	Molecular Function	15
GO:0005575	cellular_component	Cellular Component	98
GO:0003674	molecular_function	Molecular Function	126
GO:0042802	identical protein binding	Molecular Function	70
GO:0016049	cell growth	Biological Process	11
GO:0016477	cell migration	Biological Process	24
GO:0007409	axonogenesis	Biological Process	14
GO:0009986	cell surface	Cellular Component	70

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04512	ECM-receptor interaction	13	The extracellular matrix (ECM) consists of a complex mixture...... The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits. More...
hsa04510	Focal adhesion	40	Cell-matrix adhesions play essential roles in important biol...... Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. More...

Genes shared at least 5 GO terms with TNN (count: 1)

Gene Symbol	Pathway Count	Pathway List
CTGF	5	cell-matrix adhesion; proteinaceous extracellular matrix; extracellular space; integrin binding; cell migration;

Genes shared at least 2 KEGG pathways with TNN (count: 10)

Gene Symbol	Pathway Count	Pathway List
FN1	2	ECM-receptor interaction; Focal adhesion;
ITGA1	2	ECM-receptor interaction; Focal adhesion;
ITGA11	2	ECM-receptor interaction; Focal adhesion;
ITGA2	2	ECM-receptor interaction; Focal adhesion;
LAMA2	2	ECM-receptor interaction; Focal adhesion;
LAMA3	2	ECM-receptor interaction; Focal adhesion;
LAMC1	2	ECM-receptor interaction; Focal adhesion;
LAMC2	2	ECM-receptor interaction; Focal adhesion;
TNC	2	ECM-receptor interaction; Focal adhesion;
TNR	2	ECM-receptor interaction; Focal adhesion;

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Region: chr1:175036994..175117202 View in gBrowse