ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ITGA11
Symbol Alias	HsT18964
Approved Name	integrin, alpha 11
Location	15q22.3-q23
Position	chr15:68594050-68724501, -1
External Links	HGNC: 6136 Entrez Gene: 22801 Ensembl: ENSG00000137809 UCSC: uc002ari.3
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7164335	chr15:68715032(Fwd)	intron_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008305	integrin complex	cellular component	IEA	5
GO:0007155	cell adhesion	biological process	TAS[10486209]	99
GO:0007160	cell-matrix adhesion	biological process	TAS[10464311]	16
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0007517	muscle organ development	biological process	TAS[10464311]	17
GO:0005518	collagen binding	molecular function	TAS[10464311]	8
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0007229	integrin-mediated signaling pathway	biological process	IEA	10

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa04512	ECM-receptor interaction	13
hsa04510	Focal adhesion	40
hsa04810	Regulation of actin cytoskeleton	49

Genes shared at least 5 GO terms with ITGA11 (count: 4)

Gene Symbol	Pathway Count	Pathway List
ITGA2	7	integrin complex; cell adhesion; cell-matrix adhesion; plasma membrane; collagen binding; metal ion binding; integrin-mediated signaling pathway;
ITGA1	6	integrin complex; cell-matrix adhesion; plasma membrane; collagen binding; metal ion binding; integrin-mediated signaling pathway;
ITGAL	5	integrin complex; cell adhesion; plasma membrane; metal ion binding; integrin-mediated signaling pathway;
ITGAE	5	integrin complex; cell adhesion; plasma membrane; metal ion binding; integrin-mediated signaling pathway;

Genes shared at least 2 KEGG pathways with ITGA11 (count: 22)

Gene Symbol	Pathway Count	Pathway List
FN1	3	ECM-receptor interaction; Focal adhesion; Regulation of actin cytoskeleton;
ITGA2	3	ECM-receptor interaction; Focal adhesion; Regulation of actin cytoskeleton;
ITGA1	3	ECM-receptor interaction; Focal adhesion; Regulation of actin cytoskeleton;
TNN	2	ECM-receptor interaction; Focal adhesion;
TNC	2	ECM-receptor interaction; Focal adhesion;
LAMA3	2	ECM-receptor interaction; Focal adhesion;
LAMC2	2	ECM-receptor interaction; Focal adhesion;
LAMA2	2	ECM-receptor interaction; Focal adhesion;
TNR	2	ECM-receptor interaction; Focal adhesion;
LAMC1	2	ECM-receptor interaction; Focal adhesion;
ROCK2	2	Focal adhesion; Regulation of actin cytoskeleton;
PIK3R1	2	Focal adhesion; Regulation of actin cytoskeleton;
MAPK1	2	Focal adhesion; Regulation of actin cytoskeleton;
PPP1CA	2	Focal adhesion; Regulation of actin cytoskeleton;
CRKL	2	Focal adhesion; Regulation of actin cytoskeleton;
PIK3CG	2	Focal adhesion; Regulation of actin cytoskeleton;
MYLPF	2	Focal adhesion; Regulation of actin cytoskeleton;
MAPK3	2	Focal adhesion; Regulation of actin cytoskeleton;
ACTN3	2	Focal adhesion; Regulation of actin cytoskeleton;
PAK1	2	Focal adhesion; Regulation of actin cytoskeleton;
BCAR1	2	Focal adhesion; Regulation of actin cytoskeleton;
PAK7	2	Focal adhesion; Regulation of actin cytoskeleton;

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Region: chr15:68594050..68724501 View in gBrowse