ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ITGAE
Symbol Alias	CD103, HUMINAE
Approved Name	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Location	17p13
Position	chr17:3617922-3704537, -1
External Links	HGNC: 6147 Entrez Gene: 3682 Ensembl: ENSG00000083457 UCSC: uc002fwo.4
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs220470	chr17:3664975(Fwd)	intron_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs220471	chr17:3665160(Fwd)	intron_variant
rs170213	chr17:3660864(Fwd)	intron_variant; upstream_gene_variant
rs220475	chr17:3660750(Fwd)	intron_variant; upstream_gene_variant
rs1178563	chr17:3653959(Fwd)	downstream_gene_variant; intron_variant
rs6502743	chr17:3670883(Fwd)	intron_variant
rs9916609	chr17:3672514(Fwd)	intron_variant
rs12604024	chr17:3674153(Fwd)	intron_variant
rs2272606	chr17:3657159(Fwd)	missense_variant; nc_transcript_variant; non_coding_exon_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007155	cell adhesion	biological process	IEA	99
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0009897	external side of plasma membrane	cellular component	IEA	33
GO:0007229	integrin-mediated signaling pathway	biological process	IEA	10
GO:0008305	integrin complex	cellular component	IEA	5
GO:0005886	plasma membrane	cellular component	TAS	839

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	49

Genes shared at least 5 GO terms with ITGAE (count: 4)

Gene Symbol	Pathway Count	Pathway List
ITGAL	6	cell adhesion; metal ion binding; external side of plasma membrane; integrin-mediated signaling pathway; integrin complex; plasma membrane;
ITGA2	6	cell adhesion; metal ion binding; external side of plasma membrane; integrin-mediated signaling pathway; integrin complex; plasma membrane;
ITGA11	5	cell adhesion; metal ion binding; integrin-mediated signaling pathway; integrin complex; plasma membrane;
ITGA1	5	metal ion binding; external side of plasma membrane; integrin-mediated signaling pathway; integrin complex; plasma membrane;

Genes shared at least 2 KEGG pathways with ITGAE (count: 0)

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Region: chr17:3617922..3704537 View in gBrowse