ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ITGA2
Previous Symbol	CD49B
Symbol Alias	CD49b
Approved Name	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Location	5q11.2
Position	chr5:52285156-52390609, 1
External Links	HGNC: 6137 Entrez Gene: 3673 Ensembl: ENSG00000164171 UCSC: uc003joy.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 3)

Literature-origin SNPs (count: 0)

LD-proxies (count: 3)

rs_ID	Location	Functional Annotation
rs1421942	chr5:52293087(Fwd)	intron_variant; NMD_transcript_variant
rs35235	chr5:52292237(Fwd)	intron_variant; NMD_transcript_variant
rs26682	chr5:52289766(Fwd)	intron_variant; NMD_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007229	integrin-mediated signaling pathway	biological process	IEA	10
GO:0019048	virus-host interaction	biological process	IEA	61
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0005515	protein binding	molecular function	IPI	1015
GO:0007411	axon guidance	biological process	TAS	71
GO:0008305	integrin complex	cellular component	IEA	5
GO:0007155	cell adhesion	biological process	TAS[10942362]	99
GO:0007160	cell-matrix adhesion	biological process	TAS[2545729]	16
GO:0009986	cell surface	cellular component	IDA	75
GO:0007596	blood coagulation	biological process	TAS	85
GO:0045178	basal part of cell	cellular component	IEA	2
GO:0005886	plasma membrane	cellular component	IDA; TAS	839
GO:0005518	collagen binding	molecular function	TAS[9391074]	8
GO:0009887	organ morphogenesis	biological process	TAS[9391074]	19
GO:0009897	external side of plasma membrane	cellular component	IEA	33

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa04512	ECM-receptor interaction	13
hsa04510	Focal adhesion	40
hsa05222	Small cell lung cancer	17
hsa04810	Regulation of actin cytoskeleton	49
hsa04640	Hematopoietic cell lineage	13

Genes shared at least 5 GO terms with ITGA2 (count: 12)

Gene Symbol	Pathway Count	Pathway List
ITGA1	10	integrin-mediated signaling pathway; metal ion binding; protein binding; axon guidance; integrin complex; cell-matrix adhesion; basal part of cell; plasma membrane; collagen binding; external side of plasma membrane;
ITGA11	7	integrin-mediated signaling pathway; metal ion binding; integrin complex; cell adhesion; cell-matrix adhesion; plasma membrane; collagen binding;
ITGAL	7	integrin-mediated signaling pathway; metal ion binding; integrin complex; cell adhesion; blood coagulation; plasma membrane; external side of plasma membrane;
SYK	6	integrin-mediated signaling pathway; virus-host interaction; protein binding; blood coagulation; plasma membrane; organ morphogenesis;
ITGAE	6	integrin-mediated signaling pathway; metal ion binding; integrin complex; cell adhesion; plasma membrane; external side of plasma membrane;
NRXN1	6	metal ion binding; protein binding; axon guidance; cell adhesion; cell surface; plasma membrane;
BCAR1	5	integrin-mediated signaling pathway; protein binding; cell adhesion; blood coagulation; plasma membrane;
MAPK3	5	virus-host interaction; protein binding; axon guidance; blood coagulation; organ morphogenesis;
MAPK1	5	virus-host interaction; protein binding; axon guidance; blood coagulation; organ morphogenesis;
CCR5	5	virus-host interaction; protein binding; cell surface; plasma membrane; external side of plasma membrane;
ACHE	5	protein binding; cell adhesion; cell surface; plasma membrane; collagen binding;
NCAM1	5	axon guidance; cell adhesion; cell surface; plasma membrane; external side of plasma membrane;

Genes shared at least 2 KEGG pathways with ITGA2 (count: 26)

Gene Symbol	Pathway Count	Pathway List
FN1	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Regulation of actin cytoskeleton;
ITGA1	4	ECM-receptor interaction; Focal adhesion; Regulation of actin cytoskeleton; Hematopoietic cell lineage;
ITGA11	3	ECM-receptor interaction; Focal adhesion; Regulation of actin cytoskeleton;
LAMA3	3	ECM-receptor interaction; Focal adhesion; Small cell lung cancer;
LAMC2	3	ECM-receptor interaction; Focal adhesion; Small cell lung cancer;
LAMA2	3	ECM-receptor interaction; Focal adhesion; Small cell lung cancer;
LAMC1	3	ECM-receptor interaction; Focal adhesion; Small cell lung cancer;
PIK3R1	3	Focal adhesion; Small cell lung cancer; Regulation of actin cytoskeleton;
PIK3CG	3	Focal adhesion; Small cell lung cancer; Regulation of actin cytoskeleton;
TNN	2	ECM-receptor interaction; Focal adhesion;
GP1BB	2	ECM-receptor interaction; Hematopoietic cell lineage;
TNC	2	ECM-receptor interaction; Focal adhesion;
TNR	2	ECM-receptor interaction; Focal adhesion;
ROCK2	2	Focal adhesion; Regulation of actin cytoskeleton;
BIRC2	2	Focal adhesion; Small cell lung cancer;
MAPK1	2	Focal adhesion; Regulation of actin cytoskeleton;
PPP1CA	2	Focal adhesion; Regulation of actin cytoskeleton;
CRKL	2	Focal adhesion; Regulation of actin cytoskeleton;
MYLPF	2	Focal adhesion; Regulation of actin cytoskeleton;
MAPK3	2	Focal adhesion; Regulation of actin cytoskeleton;
ACTN3	2	Focal adhesion; Regulation of actin cytoskeleton;
BIRC3	2	Focal adhesion; Small cell lung cancer;
PAK1	2	Focal adhesion; Regulation of actin cytoskeleton;
CCND1	2	Focal adhesion; Small cell lung cancer;
BCAR1	2	Focal adhesion; Regulation of actin cytoskeleton;
PAK7	2	Focal adhesion; Regulation of actin cytoskeleton;

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Region: chr5:52285156..52390609 View in gBrowse