ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FN1
Symbol Alias	MSF, CIG, LETS, GFND2, FINC
Approved Name	fibronectin 1
Name Alias	"migration-stimulating factor", "cold-insoluble globulin"
Location	2q34
Position	chr2:216225163-216300895, -1
External Links	HGNC: 3778 Entrez Gene: 2335 Ensembl: ENSG00000115414 UCSC: uc002vfa.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001525	angiogenesis	biological process	IEA	38
GO:0007596	blood coagulation	biological process	TAS	85
GO:0005576	extracellular region	cellular component	NAS[14718574]; TAS	267
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	cellular component	IDA[15308636]	19
GO:0008201	heparin binding	molecular function	NAS[10075919]	28
GO:0005604	basement membrane	cellular component	IEA	13
GO:0005201	extracellular matrix structural constituent	molecular function	NAS	5
GO:0008360	regulation of cell shape	biological process	IEA	21
GO:0007044	cell-substrate junction assembly	biological process	IEA	2
GO:0005518	collagen binding	molecular function	NAS[3024962]	8
GO:0030168	platelet activation	biological process	TAS	38
GO:0005578	proteinaceous extracellular matrix	cellular component	NAS	51
GO:0005515	protein binding	molecular function	IPI[2531657]	1015
GO:0007161	calcium-independent cell-matrix adhesion	biological process	IEA	2
GO:0031093	platelet alpha granule lumen	cellular component	TAS	5
GO:0016504	peptidase activator activity	molecular function	IEA	1
GO:0016324	apical plasma membrane	cellular component	IEA	52
GO:0034446	substrate adhesion-dependent cell spreading	biological process	IDA[16236823]	4
GO:0031012	extracellular matrix	cellular component	IDA[1632457]; IDA; ISS	29
GO:0016477	cell migration	biological process	NAS	25
GO:0050900	leukocyte migration	biological process	TAS	13
GO:0018149	peptide cross-linking	biological process	IDA[3997886]	3
GO:0005577	fibrinogen complex	cellular component	IDA[3997886]	1
GO:0002576	platelet degranulation	biological process	TAS	11
GO:0006953	acute-phase response	biological process	IEA	12
GO:0007155	cell adhesion	biological process	NAS[1423622]	99
GO:0005615	extracellular space	cellular component	IDA	133
GO:0009611	response to wounding	biological process	NAS[7989369]	9

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa04512	ECM-receptor interaction	13
hsa04510	Focal adhesion	40
hsa05222	Small cell lung cancer	17
hsa04810	Regulation of actin cytoskeleton	49
hsa01430	Cell Communication	23

Genes shared at least 5 GO terms with FN1 (count: 22)

Gene Symbol	Pathway Count	Pathway List
VEGFA	11	angiogenesis; blood coagulation; extracellular region; heparin binding; regulation of cell shape; platelet activation; proteinaceous extracellular matrix; protein binding; platelet alpha granule lumen; platelet degranulation; extracellular space;
VEGFB	9	angiogenesis; blood coagulation; extracellular region; heparin binding; platelet activation; protein binding; platelet alpha granule lumen; platelet degranulation; extracellular space;
LAMC1	8	extracellular region; basement membrane; extracellular matrix structural constituent; substrate adhesion-dependent cell spreading; extracellular matrix; cell migration; cell adhesion; extracellular space;
CTGF	7	angiogenesis; extracellular region; heparin binding; proteinaceous extracellular matrix; cell migration; extracellular space; response to wounding;
COL15A1	7	angiogenesis; extracellular region; basement membrane; extracellular matrix structural constituent; extracellular matrix; cell adhesion; extracellular space;
SERPING1	7	blood coagulation; extracellular region; platelet activation; protein binding; platelet alpha granule lumen; platelet degranulation; extracellular space;
APOA1	6	blood coagulation; extracellular region; platelet activation; protein binding; platelet degranulation; extracellular space;
F2RL2	6	blood coagulation; extracellular region; platelet activation; protein binding; apical plasma membrane; response to wounding;
ALDOA	6	blood coagulation; extracellular region; regulation of cell shape; platelet activation; platelet alpha granule lumen; platelet degranulation;
TNC	6	extracellular region; basement membrane; extracellular matrix; cell adhesion; extracellular space; response to wounding;
ACHE	6	extracellular region; collagen binding; protein binding; cell adhesion; extracellular space; response to wounding;
FGF9	5	angiogenesis; extracellular region; heparin binding; basement membrane; extracellular space;
FGF10	5	angiogenesis; extracellular region; heparin binding; extracellular matrix; extracellular space;
JAM3	5	angiogenesis; blood coagulation; protein binding; leukocyte migration; extracellular space;
COL8A1	5	angiogenesis; extracellular region; basement membrane; extracellular matrix; cell adhesion;
BCAR1	5	blood coagulation; platelet activation; protein binding; cell migration; cell adhesion;
SERPINC1	5	blood coagulation; extracellular region; heparin binding; protein binding; extracellular space;
HABP4	5	blood coagulation; extracellular region; platelet activation; protein binding; platelet degranulation;
HSPA5	5	blood coagulation; endoplasmic reticulum-Golgi intermediate compartment; platelet activation; protein binding; platelet degranulation;
LPL	5	extracellular region; heparin binding; protein binding; extracellular matrix; extracellular space;
IL6	5	extracellular region; regulation of cell shape; platelet activation; acute-phase response; extracellular space;
OGN	5	extracellular region; proteinaceous extracellular matrix; protein binding; extracellular matrix; extracellular space;

Genes shared at least 2 KEGG pathways with FN1 (count: 25)

Gene Symbol	Pathway Count	Pathway List
ITGA2	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Regulation of actin cytoskeleton;
LAMA3	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
LAMC2	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
LAMA2	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
LAMC1	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
ITGA11	3	ECM-receptor interaction; Focal adhesion; Regulation of actin cytoskeleton;
TNN	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
TNC	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
TNR	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
ITGA1	3	ECM-receptor interaction; Focal adhesion; Regulation of actin cytoskeleton;
PIK3R1	3	Focal adhesion; Small cell lung cancer; Regulation of actin cytoskeleton;
PIK3CG	3	Focal adhesion; Small cell lung cancer; Regulation of actin cytoskeleton;
ROCK2	2	Focal adhesion; Regulation of actin cytoskeleton;
BIRC2	2	Focal adhesion; Small cell lung cancer;
MAPK1	2	Focal adhesion; Regulation of actin cytoskeleton;
PPP1CA	2	Focal adhesion; Regulation of actin cytoskeleton;
CRKL	2	Focal adhesion; Regulation of actin cytoskeleton;
MYLPF	2	Focal adhesion; Regulation of actin cytoskeleton;
MAPK3	2	Focal adhesion; Regulation of actin cytoskeleton;
ACTN3	2	Focal adhesion; Regulation of actin cytoskeleton;
BIRC3	2	Focal adhesion; Small cell lung cancer;
PAK1	2	Focal adhesion; Regulation of actin cytoskeleton;
CCND1	2	Focal adhesion; Small cell lung cancer;
BCAR1	2	Focal adhesion; Regulation of actin cytoskeleton;
PAK7	2	Focal adhesion; Regulation of actin cytoskeleton;

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Region: chr2:216225163..216300895 View in gBrowse